Follow-up outcomes of endoscopic resection for early gastric cancer with undifferentiated histology

Jie Hyun Kim, Yong Hoon Kim, Da Hyun Jung, Han Ho Jeon, Yong Chan Lee, Hyuk Lee, Sang Kil Lee, Jun Chul Park, Sung Kwan Shin, Young Hoon Youn, Hyojin Park

Research output: Contribution to journalArticle

23 Citations (Scopus)

Abstract

Background: The application of endoscopic resection (ER) for undifferentiated-type early gastric cancer (UD-EGC) remains controversial. The aim was to examine long-term outcomes of ER for UD-EGC. Furthermore, we investigated whether long-term outcomes of ER differed between poorly differentiated adenocarcinoma (PD) and signet ring cell carcinoma (SRC). Methods: From 2001 to 2011, 209 lesions in 209 patients with UD-EGC (82 PD; 127 SRC) were treated by ER. We retrospectively assessed the clinical outcomes of ER in 209 patients. The survival rate and disease-free survival rates after ER were evaluated as long-term outcomes. Results: The en bloc resection and curative resection (CR) rates were 91.4 and 55.0 %, respectively. The en bloc and CR rates in PD were 90.2 and 45.1 %, whereas those in SRC were 92.1 and 61.4 %. For patients with PD who underwent non-curative resections, 51.1 % were vertical-cut end-positive and for those with SRC, 63.3 % were lateral-cut end-positive, a statistically significant difference. In those patients where CR was achieved, no case of local recurrence or distant metastasis was observed during the follow-up period (32.7 ± 22.2 months). The 3- and 5-year survival rates were 99.0 and 98.6 %, with no significant difference between CR patients with SRC and PD. Conclusions: ER may yield good long-term outcomes for UD-EGC if CR is achieved, with no difference between PD and SRC. However, to increase the current CR rate of ER, stricter criteria for performing ER in UD-EGC may be required.

Original languageEnglish
Pages (from-to)2627-2633
Number of pages7
JournalSurgical endoscopy
Volume28
Issue number9
DOIs
Publication statusPublished - 2014 Sep

Fingerprint

Signet Ring Cell Carcinoma
Stomach Neoplasms
Histology
Adenocarcinoma
Survival Rate
Disease-Free Survival
Neoplasm Metastasis
Recurrence

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Kim, Jie Hyun ; Kim, Yong Hoon ; Jung, Da Hyun ; Jeon, Han Ho ; Lee, Yong Chan ; Lee, Hyuk ; Lee, Sang Kil ; Park, Jun Chul ; Shin, Sung Kwan ; Youn, Young Hoon ; Park, Hyojin. / Follow-up outcomes of endoscopic resection for early gastric cancer with undifferentiated histology. In: Surgical endoscopy. 2014 ; Vol. 28, No. 9. pp. 2627-2633.
@article{b2fcf3244dcb4adcb908d9dc9ac5a497,
title = "Follow-up outcomes of endoscopic resection for early gastric cancer with undifferentiated histology",
abstract = "Background: The application of endoscopic resection (ER) for undifferentiated-type early gastric cancer (UD-EGC) remains controversial. The aim was to examine long-term outcomes of ER for UD-EGC. Furthermore, we investigated whether long-term outcomes of ER differed between poorly differentiated adenocarcinoma (PD) and signet ring cell carcinoma (SRC). Methods: From 2001 to 2011, 209 lesions in 209 patients with UD-EGC (82 PD; 127 SRC) were treated by ER. We retrospectively assessed the clinical outcomes of ER in 209 patients. The survival rate and disease-free survival rates after ER were evaluated as long-term outcomes. Results: The en bloc resection and curative resection (CR) rates were 91.4 and 55.0 {\%}, respectively. The en bloc and CR rates in PD were 90.2 and 45.1 {\%}, whereas those in SRC were 92.1 and 61.4 {\%}. For patients with PD who underwent non-curative resections, 51.1 {\%} were vertical-cut end-positive and for those with SRC, 63.3 {\%} were lateral-cut end-positive, a statistically significant difference. In those patients where CR was achieved, no case of local recurrence or distant metastasis was observed during the follow-up period (32.7 ± 22.2 months). The 3- and 5-year survival rates were 99.0 and 98.6 {\%}, with no significant difference between CR patients with SRC and PD. Conclusions: ER may yield good long-term outcomes for UD-EGC if CR is achieved, with no difference between PD and SRC. However, to increase the current CR rate of ER, stricter criteria for performing ER in UD-EGC may be required.",
author = "Kim, {Jie Hyun} and Kim, {Yong Hoon} and Jung, {Da Hyun} and Jeon, {Han Ho} and Lee, {Yong Chan} and Hyuk Lee and Lee, {Sang Kil} and Park, {Jun Chul} and Shin, {Sung Kwan} and Youn, {Young Hoon} and Hyojin Park",
year = "2014",
month = "9",
doi = "10.1007/s00464-014-3514-x",
language = "English",
volume = "28",
pages = "2627--2633",
journal = "Surgical Endoscopy",
issn = "0930-2794",
publisher = "Springer New York",
number = "9",

}

Follow-up outcomes of endoscopic resection for early gastric cancer with undifferentiated histology. / Kim, Jie Hyun; Kim, Yong Hoon; Jung, Da Hyun; Jeon, Han Ho; Lee, Yong Chan; Lee, Hyuk; Lee, Sang Kil; Park, Jun Chul; Shin, Sung Kwan; Youn, Young Hoon; Park, Hyojin.

In: Surgical endoscopy, Vol. 28, No. 9, 09.2014, p. 2627-2633.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Follow-up outcomes of endoscopic resection for early gastric cancer with undifferentiated histology

AU - Kim, Jie Hyun

AU - Kim, Yong Hoon

AU - Jung, Da Hyun

AU - Jeon, Han Ho

AU - Lee, Yong Chan

AU - Lee, Hyuk

AU - Lee, Sang Kil

AU - Park, Jun Chul

AU - Shin, Sung Kwan

AU - Youn, Young Hoon

AU - Park, Hyojin

PY - 2014/9

Y1 - 2014/9

N2 - Background: The application of endoscopic resection (ER) for undifferentiated-type early gastric cancer (UD-EGC) remains controversial. The aim was to examine long-term outcomes of ER for UD-EGC. Furthermore, we investigated whether long-term outcomes of ER differed between poorly differentiated adenocarcinoma (PD) and signet ring cell carcinoma (SRC). Methods: From 2001 to 2011, 209 lesions in 209 patients with UD-EGC (82 PD; 127 SRC) were treated by ER. We retrospectively assessed the clinical outcomes of ER in 209 patients. The survival rate and disease-free survival rates after ER were evaluated as long-term outcomes. Results: The en bloc resection and curative resection (CR) rates were 91.4 and 55.0 %, respectively. The en bloc and CR rates in PD were 90.2 and 45.1 %, whereas those in SRC were 92.1 and 61.4 %. For patients with PD who underwent non-curative resections, 51.1 % were vertical-cut end-positive and for those with SRC, 63.3 % were lateral-cut end-positive, a statistically significant difference. In those patients where CR was achieved, no case of local recurrence or distant metastasis was observed during the follow-up period (32.7 ± 22.2 months). The 3- and 5-year survival rates were 99.0 and 98.6 %, with no significant difference between CR patients with SRC and PD. Conclusions: ER may yield good long-term outcomes for UD-EGC if CR is achieved, with no difference between PD and SRC. However, to increase the current CR rate of ER, stricter criteria for performing ER in UD-EGC may be required.

AB - Background: The application of endoscopic resection (ER) for undifferentiated-type early gastric cancer (UD-EGC) remains controversial. The aim was to examine long-term outcomes of ER for UD-EGC. Furthermore, we investigated whether long-term outcomes of ER differed between poorly differentiated adenocarcinoma (PD) and signet ring cell carcinoma (SRC). Methods: From 2001 to 2011, 209 lesions in 209 patients with UD-EGC (82 PD; 127 SRC) were treated by ER. We retrospectively assessed the clinical outcomes of ER in 209 patients. The survival rate and disease-free survival rates after ER were evaluated as long-term outcomes. Results: The en bloc resection and curative resection (CR) rates were 91.4 and 55.0 %, respectively. The en bloc and CR rates in PD were 90.2 and 45.1 %, whereas those in SRC were 92.1 and 61.4 %. For patients with PD who underwent non-curative resections, 51.1 % were vertical-cut end-positive and for those with SRC, 63.3 % were lateral-cut end-positive, a statistically significant difference. In those patients where CR was achieved, no case of local recurrence or distant metastasis was observed during the follow-up period (32.7 ± 22.2 months). The 3- and 5-year survival rates were 99.0 and 98.6 %, with no significant difference between CR patients with SRC and PD. Conclusions: ER may yield good long-term outcomes for UD-EGC if CR is achieved, with no difference between PD and SRC. However, to increase the current CR rate of ER, stricter criteria for performing ER in UD-EGC may be required.

UR - http://www.scopus.com/inward/record.url?scp=84906934461&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84906934461&partnerID=8YFLogxK

U2 - 10.1007/s00464-014-3514-x

DO - 10.1007/s00464-014-3514-x

M3 - Article

C2 - 24718663

AN - SCOPUS:84906934461

VL - 28

SP - 2627

EP - 2633

JO - Surgical Endoscopy

JF - Surgical Endoscopy

SN - 0930-2794

IS - 9

ER -