Abstract
We investigated whether follow-up ultrasound (US) is enough for thyroid nodules 5–10 mm, and whether 3 years of interval between the initial US and next US is appropriate. This retrospective study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. The study included 447 thyroid nodules 5–10 mm from 378 patients who underwent initial thyroid US, and underwent 3 years or more of follow-up US. The presence and characteristics of malignancy detected on follow-up were reviewed. Maximal diameters of each nodule at the initial and last US were measured. Univariate and multivariate analysis were used to assess association with nodule growth 3 mm or larger. Seven malignancies (1.6 %, 7 of 447) were detected on a mean 70.6 ± 20.3 months (range 36–104 months). Only one had growth 3 mm or larger, and all malignancies did not have extensive extrathyroidal extension, lateral lymph nodes, or distant metastasis. 6.0 % (27 of 447) of nodules had growth 3 mm or larger. Nodules in older patients were less likely to grow, and benign-looking nodules were more likely to grow. Longer follow-up time 6 years or more was not associated with growth, and no cancers were detected during the long follow-up time. Immediate US-FNA for thyroid nodules 5–10 mm are discouraged, unless suspicious metastatic lymph nodes are present. Also, a follow-up US 3 years after the initial US may be enough for these nodules.
| Original language | English |
|---|---|
| Pages (from-to) | 130-138 |
| Number of pages | 9 |
| Journal | Endocrine |
| Volume | 52 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2016 Apr 1 |
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All Science Journal Classification (ASJC) codes
- Endocrinology, Diabetes and Metabolism
- Endocrinology
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Follow-up ultrasound may be enough for thyroid nodules from 5 mm to 1 cm in size. / Kim, Soo Yeon; Lee, Hye Sun; Kim, Eunkyung; Moon, Hee Jung; Yoon, Jung Hyun; Hong, Jung Hwa; kwak, jinyoung.
In: Endocrine, Vol. 52, No. 1, 01.04.2016, p. 130-138.Research output: Contribution to journal › Article
TY - JOUR
T1 - Follow-up ultrasound may be enough for thyroid nodules from 5 mm to 1 cm in size
AU - Kim, Soo Yeon
AU - Lee, Hye Sun
AU - Kim, Eunkyung
AU - Moon, Hee Jung
AU - Yoon, Jung Hyun
AU - Hong, Jung Hwa
AU - kwak, jinyoung
PY - 2016/4/1
Y1 - 2016/4/1
N2 - We investigated whether follow-up ultrasound (US) is enough for thyroid nodules 5–10 mm, and whether 3 years of interval between the initial US and next US is appropriate. This retrospective study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. The study included 447 thyroid nodules 5–10 mm from 378 patients who underwent initial thyroid US, and underwent 3 years or more of follow-up US. The presence and characteristics of malignancy detected on follow-up were reviewed. Maximal diameters of each nodule at the initial and last US were measured. Univariate and multivariate analysis were used to assess association with nodule growth 3 mm or larger. Seven malignancies (1.6 %, 7 of 447) were detected on a mean 70.6 ± 20.3 months (range 36–104 months). Only one had growth 3 mm or larger, and all malignancies did not have extensive extrathyroidal extension, lateral lymph nodes, or distant metastasis. 6.0 % (27 of 447) of nodules had growth 3 mm or larger. Nodules in older patients were less likely to grow, and benign-looking nodules were more likely to grow. Longer follow-up time 6 years or more was not associated with growth, and no cancers were detected during the long follow-up time. Immediate US-FNA for thyroid nodules 5–10 mm are discouraged, unless suspicious metastatic lymph nodes are present. Also, a follow-up US 3 years after the initial US may be enough for these nodules.
AB - We investigated whether follow-up ultrasound (US) is enough for thyroid nodules 5–10 mm, and whether 3 years of interval between the initial US and next US is appropriate. This retrospective study was approved by the Institutional Review Board, and the need to obtain informed consent was waived. The study included 447 thyroid nodules 5–10 mm from 378 patients who underwent initial thyroid US, and underwent 3 years or more of follow-up US. The presence and characteristics of malignancy detected on follow-up were reviewed. Maximal diameters of each nodule at the initial and last US were measured. Univariate and multivariate analysis were used to assess association with nodule growth 3 mm or larger. Seven malignancies (1.6 %, 7 of 447) were detected on a mean 70.6 ± 20.3 months (range 36–104 months). Only one had growth 3 mm or larger, and all malignancies did not have extensive extrathyroidal extension, lateral lymph nodes, or distant metastasis. 6.0 % (27 of 447) of nodules had growth 3 mm or larger. Nodules in older patients were less likely to grow, and benign-looking nodules were more likely to grow. Longer follow-up time 6 years or more was not associated with growth, and no cancers were detected during the long follow-up time. Immediate US-FNA for thyroid nodules 5–10 mm are discouraged, unless suspicious metastatic lymph nodes are present. Also, a follow-up US 3 years after the initial US may be enough for these nodules.
UR - http://www.scopus.com/inward/record.url?scp=84944711418&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84944711418&partnerID=8YFLogxK
U2 - 10.1007/s12020-015-0740-5
DO - 10.1007/s12020-015-0740-5
M3 - Article
C2 - 26394881
AN - SCOPUS:84944711418
VL - 52
SP - 130
EP - 138
JO - Endocrine
JF - Endocrine
SN - 0969-711X
IS - 1
ER -