Four new pregnane glycosides from Gymnema latifolium and their α-glucosidase and α-amylase inhibitory activities

Duong Thi Hai Yen, Do Thi Trang, Bui Huu Tai, Vu Van Doan, Pham Hai Yen, Nguyen Xuan Nhiem, Chau Van Minh, Manh Hoang Duc, Seon Ju Park, Jae Hyuk Lee, Sun Yeou Kim, Seung Hyun Kim, Phan Van Kiem

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Four new pregnane glycosides, gymlatifosides A - D (1 − 4) and one known pregnane glycoside, verticilloside J (5) were isolated from the leaves of Gymnema latifolium Wall. ex Wight. Their chemical structures were elucidated on the basis of extensive spectroscopic methods, including 1D, 2D NMR, HR-ESI-MS, and in comparison with the reported data. All these compounds were tested for α-glucosidase and α-amylase inhibitory activities. Compound 5 exhibited the most anti α-glucosidase activity with inhibitory percentage of 37.8 ± 1.5% at the concentration of 200 μM. Compounds 1–4 showed moderate anti α-glucosidase activity with inhibitory percentage ranging from 7.0 to 30.1%. In addition, all compounds 1–5 showed moderate/weak anti α-amylase activity in the investigated test.

Original languageEnglish
Pages (from-to)4460-4467
Number of pages8
JournalNatural Product Research
Volume35
Issue number22
DOIs
Publication statusPublished - 2021

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number 104.01-2017.25.

Publisher Copyright:
© 2020 Informa UK Limited, trading as Taylor & Francis Group.

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biochemistry
  • Plant Science
  • Organic Chemistry

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