Four new sucrose diesters of substituted truxinic acids from Trigonostemon honbaensis with their anoctamin-1 inhibitory activity

Ninh Khac Ban, Luu Hong Truong, Tran Van Tiep, Duong Thi Hai Yen, Vu Van Doan, Nguyen Xuan Nhiem, Yohan Seo, Wan Namkung, Seung Hyun Kim, Bui Huu Tai, Phan Van Kiem

Research output: Contribution to journalArticle

Abstract

Truxinic acid sucrose diesters analogs possess interesting chemical structure by the presence of cyclobutane-ring and macrocyclic sucrose diesters moieties which are rarely found from natural sources. This paper describes the isolation and structural elucidation of four new sucrose diesters of substituted truxinic acids, trigohonbanosides A-D (1–4), from the leaves of Trigonostemon honbaensis. Their chemical structures were elucidated by HR-ESI-MS, NMR, and CD spectroscopic methods. At a concentration of 30 µM, compounds 1–4 moderately inhibited ANO-1 activity with inhibitory percentages of 27.7 ± 1.10%, 35.6 ± 0.92%, 43.7 ± 1.61%, and 40.8 ± 1.25%, respectively.

Original languageEnglish
Article number104058
JournalBioorganic Chemistry
Volume102
DOIs
Publication statusPublished - 2020 Sep

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number: 104.01-2018.300 .

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Drug Discovery
  • Organic Chemistry

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