Four new sucrose diesters of substituted truxinic acids from Trigonostemon honbaensis with their anoctamin-1 inhibitory activity

Ninh Khac Ban; Luu Hong Truong; Tran Van Tiep; Duong Thi Hai Yen; Vu Van Doan; Nguyen Xuan Nhiem; Yohan Seo; Wan Namkung; Seung Hyun Kim; Bui Huu Tai; Phan Van Kiem

doi:10.1016/j.bioorg.2020.104058

Four new sucrose diesters of substituted truxinic acids from Trigonostemon honbaensis with their anoctamin-1 inhibitory activity

Ninh Khac Ban, Luu Hong Truong, Tran Van Tiep, Duong Thi Hai Yen, Vu Van Doan, Nguyen Xuan Nhiem, Yohan Seo, Wan Namkung, Seung Hyun Kim, Bui Huu Tai, Phan Van Kiem

Department of Pharmacy

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Truxinic acid sucrose diesters analogs possess interesting chemical structure by the presence of cyclobutane-ring and macrocyclic sucrose diesters moieties which are rarely found from natural sources. This paper describes the isolation and structural elucidation of four new sucrose diesters of substituted truxinic acids, trigohonbanosides A-D (1–4), from the leaves of Trigonostemon honbaensis. Their chemical structures were elucidated by HR-ESI-MS, NMR, and CD spectroscopic methods. At a concentration of 30 µM, compounds 1–4 moderately inhibited ANO-1 activity with inhibitory percentages of 27.7 ± 1.10%, 35.6 ± 0.92%, 43.7 ± 1.61%, and 40.8 ± 1.25%, respectively.

Original language	English
Article number	104058
Journal	Bioorganic Chemistry
Volume	102
DOIs	https://doi.org/10.1016/j.bioorg.2020.104058
Publication status	Published - 2020 Sept

Bibliographical note

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number: 104.01-2018.300 .

Funding Information:
This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number: 104.01-2018.300.

Publisher Copyright:
© 2020 Elsevier Inc.

All Science Journal Classification (ASJC) codes

Biochemistry
Molecular Biology
Drug Discovery
Organic Chemistry

Access to Document

10.1016/j.bioorg.2020.104058

Cite this

@article{90faa3bbabbf4a2681a91e230658a7de,

title = "Four new sucrose diesters of substituted truxinic acids from Trigonostemon honbaensis with their anoctamin-1 inhibitory activity",

abstract = "Truxinic acid sucrose diesters analogs possess interesting chemical structure by the presence of cyclobutane-ring and macrocyclic sucrose diesters moieties which are rarely found from natural sources. This paper describes the isolation and structural elucidation of four new sucrose diesters of substituted truxinic acids, trigohonbanosides A-D (1–4), from the leaves of Trigonostemon honbaensis. Their chemical structures were elucidated by HR-ESI-MS, NMR, and CD spectroscopic methods. At a concentration of 30 µM, compounds 1–4 moderately inhibited ANO-1 activity with inhibitory percentages of 27.7 ± 1.10%, 35.6 ± 0.92%, 43.7 ± 1.61%, and 40.8 ± 1.25%, respectively.",

author = "Ban, {Ninh Khac} and Truong, {Luu Hong} and Tiep, {Tran Van} and Yen, {Duong Thi Hai} and Doan, {Vu Van} and Nhiem, {Nguyen Xuan} and Yohan Seo and Wan Namkung and Kim, {Seung Hyun} and Tai, {Bui Huu} and Kiem, {Phan Van}",

note = "Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number: 104.01-2018.300 . Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number: 104.01-2018.300. Publisher Copyright: {\textcopyright} 2020 Elsevier Inc.",

year = "2020",

month = sep,

doi = "10.1016/j.bioorg.2020.104058",

language = "English",

volume = "102",

journal = "Bioorganic Chemistry",

issn = "0045-2068",

publisher = "Academic Press Inc.",

}

TY - JOUR

T1 - Four new sucrose diesters of substituted truxinic acids from Trigonostemon honbaensis with their anoctamin-1 inhibitory activity

AU - Ban, Ninh Khac

AU - Truong, Luu Hong

AU - Tiep, Tran Van

AU - Yen, Duong Thi Hai

AU - Doan, Vu Van

AU - Nhiem, Nguyen Xuan

AU - Seo, Yohan

AU - Namkung, Wan

AU - Kim, Seung Hyun

AU - Tai, Bui Huu

AU - Kiem, Phan Van

N1 - Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number: 104.01-2018.300 . Funding Information: This research is funded by Vietnam National Foundation for Science and Technology Development (NAFOSTED) under grant number: 104.01-2018.300. Publisher Copyright: © 2020 Elsevier Inc.

PY - 2020/9

Y1 - 2020/9

N2 - Truxinic acid sucrose diesters analogs possess interesting chemical structure by the presence of cyclobutane-ring and macrocyclic sucrose diesters moieties which are rarely found from natural sources. This paper describes the isolation and structural elucidation of four new sucrose diesters of substituted truxinic acids, trigohonbanosides A-D (1–4), from the leaves of Trigonostemon honbaensis. Their chemical structures were elucidated by HR-ESI-MS, NMR, and CD spectroscopic methods. At a concentration of 30 µM, compounds 1–4 moderately inhibited ANO-1 activity with inhibitory percentages of 27.7 ± 1.10%, 35.6 ± 0.92%, 43.7 ± 1.61%, and 40.8 ± 1.25%, respectively.

AB - Truxinic acid sucrose diesters analogs possess interesting chemical structure by the presence of cyclobutane-ring and macrocyclic sucrose diesters moieties which are rarely found from natural sources. This paper describes the isolation and structural elucidation of four new sucrose diesters of substituted truxinic acids, trigohonbanosides A-D (1–4), from the leaves of Trigonostemon honbaensis. Their chemical structures were elucidated by HR-ESI-MS, NMR, and CD spectroscopic methods. At a concentration of 30 µM, compounds 1–4 moderately inhibited ANO-1 activity with inhibitory percentages of 27.7 ± 1.10%, 35.6 ± 0.92%, 43.7 ± 1.61%, and 40.8 ± 1.25%, respectively.

UR - http://www.scopus.com/inward/record.url?scp=85087955380&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85087955380&partnerID=8YFLogxK

U2 - 10.1016/j.bioorg.2020.104058

DO - 10.1016/j.bioorg.2020.104058

M3 - Article

C2 - 32683177

AN - SCOPUS:85087955380

SN - 0045-2068

VL - 102

JO - Bioorganic Chemistry

JF - Bioorganic Chemistry

M1 - 104058

ER -

Four new sucrose diesters of substituted truxinic acids from Trigonostemon honbaensis with their anoctamin-1 inhibitory activity

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Fingerprint

Cite this