Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children

Mi Ae Oh, Jung Yeon Shim, Young Ho Jung, Ju Hee Seo, Hyung Young Kim, Ji Won Kwon, Byoung Ju Kim, Hyo Bin Kim, Woo Kyung Kim, So Yeon Lee, Gwang Cheon Jang, Dae Jin Song, Ha Jung Kim, Yee Jin Shin, Jung Won Park, Sang Heon Cho, Joo Shil Lee, Soo Jong Hong

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Background Asthma is a chronic lower airway inflammatory disease. Nitric oxide is an inflammatory mediator produced endogenously in the airway. Previous studies have demonstrated that the fractional concentration of exhaled nitric oxide (FeNO) is increased in asthma. Objectives To investigate if FeNO concentrations were correlated with wheezing phenotypes in preschool children and to compare the FeNO results with airway hyperresponsiveness (AHR) and pulmonary function test (PFT) results. Methods We performed skin prick tests, methacholine provocation tests, PFT, impulse oscillometry bronchodilator response (IOS BDR) tests, and FeNO measurements in 372 preschool children between the ages of 4 and 6 years. Wheezing phenotypes were defined according to the age of onset and persistency. Results Persistent wheezers had higher FeNO levels than transient wheezers and non-wheezers. Among persistent wheezers, those with atopy and AHR had significantly higher FeNO levels than those without atopy or AHR. FeNO levels were significantly higher in late-onset wheezers than early-onset wheezers and non-wheezers. Among late-onset wheezers, those with atopy and AHR had a significantly higher FeNO concentration than those without atopy or AHR as well as those with either atopy or AHR. However, there were no significant differences in AHR, PFT, or IOS BDR between persistent and transient wheezers or between late-onset wheezers and early-onset wheezers. Conclusion FeNO may be a better marker for asthma phenotypes in preschool children than AHR and PFT results. Pediatr Pulmonol. 2013; 48:563-570. © 2012 Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)563-570
Number of pages8
JournalPediatric Pulmonology
Volume48
Issue number6
DOIs
Publication statusPublished - 2013 Jun 1

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Respiratory Sounds
Preschool Children
Nitric Oxide
Phenotype
Respiratory Function Tests
Oscillometry
Asthma
Bronchodilator Agents
Methacholine Chloride
Skin Tests
Age of Onset

All Science Journal Classification (ASJC) codes

  • Pediatrics, Perinatology, and Child Health
  • Pulmonary and Respiratory Medicine

Cite this

Oh, M. A., Shim, J. Y., Jung, Y. H., Seo, J. H., Young Kim, H., Kwon, J. W., ... Hong, S. J. (2013). Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children. Pediatric Pulmonology, 48(6), 563-570. https://doi.org/10.1002/ppul.22705
Oh, Mi Ae ; Shim, Jung Yeon ; Jung, Young Ho ; Seo, Ju Hee ; Young Kim, Hyung ; Kwon, Ji Won ; Kim, Byoung Ju ; Kim, Hyo Bin ; Kim, Woo Kyung ; Lee, So Yeon ; Jang, Gwang Cheon ; Song, Dae Jin ; Kim, Ha Jung ; Shin, Yee Jin ; Park, Jung Won ; Cho, Sang Heon ; Lee, Joo Shil ; Hong, Soo Jong. / Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children. In: Pediatric Pulmonology. 2013 ; Vol. 48, No. 6. pp. 563-570.
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abstract = "Background Asthma is a chronic lower airway inflammatory disease. Nitric oxide is an inflammatory mediator produced endogenously in the airway. Previous studies have demonstrated that the fractional concentration of exhaled nitric oxide (FeNO) is increased in asthma. Objectives To investigate if FeNO concentrations were correlated with wheezing phenotypes in preschool children and to compare the FeNO results with airway hyperresponsiveness (AHR) and pulmonary function test (PFT) results. Methods We performed skin prick tests, methacholine provocation tests, PFT, impulse oscillometry bronchodilator response (IOS BDR) tests, and FeNO measurements in 372 preschool children between the ages of 4 and 6 years. Wheezing phenotypes were defined according to the age of onset and persistency. Results Persistent wheezers had higher FeNO levels than transient wheezers and non-wheezers. Among persistent wheezers, those with atopy and AHR had significantly higher FeNO levels than those without atopy or AHR. FeNO levels were significantly higher in late-onset wheezers than early-onset wheezers and non-wheezers. Among late-onset wheezers, those with atopy and AHR had a significantly higher FeNO concentration than those without atopy or AHR as well as those with either atopy or AHR. However, there were no significant differences in AHR, PFT, or IOS BDR between persistent and transient wheezers or between late-onset wheezers and early-onset wheezers. Conclusion FeNO may be a better marker for asthma phenotypes in preschool children than AHR and PFT results. Pediatr Pulmonol. 2013; 48:563-570. {\circledC} 2012 Wiley Periodicals, Inc.",
author = "Oh, {Mi Ae} and Shim, {Jung Yeon} and Jung, {Young Ho} and Seo, {Ju Hee} and {Young Kim}, Hyung and Kwon, {Ji Won} and Kim, {Byoung Ju} and Kim, {Hyo Bin} and Kim, {Woo Kyung} and Lee, {So Yeon} and Jang, {Gwang Cheon} and Song, {Dae Jin} and Kim, {Ha Jung} and Shin, {Yee Jin} and Park, {Jung Won} and Cho, {Sang Heon} and Lee, {Joo Shil} and Hong, {Soo Jong}",
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Oh, MA, Shim, JY, Jung, YH, Seo, JH, Young Kim, H, Kwon, JW, Kim, BJ, Kim, HB, Kim, WK, Lee, SY, Jang, GC, Song, DJ, Kim, HJ, Shin, YJ, Park, JW, Cho, SH, Lee, JS & Hong, SJ 2013, 'Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children', Pediatric Pulmonology, vol. 48, no. 6, pp. 563-570. https://doi.org/10.1002/ppul.22705

Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children. / Oh, Mi Ae; Shim, Jung Yeon; Jung, Young Ho; Seo, Ju Hee; Young Kim, Hyung; Kwon, Ji Won; Kim, Byoung Ju; Kim, Hyo Bin; Kim, Woo Kyung; Lee, So Yeon; Jang, Gwang Cheon; Song, Dae Jin; Kim, Ha Jung; Shin, Yee Jin; Park, Jung Won; Cho, Sang Heon; Lee, Joo Shil; Hong, Soo Jong.

In: Pediatric Pulmonology, Vol. 48, No. 6, 01.06.2013, p. 563-570.

Research output: Contribution to journalArticle

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T1 - Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children

AU - Oh, Mi Ae

AU - Shim, Jung Yeon

AU - Jung, Young Ho

AU - Seo, Ju Hee

AU - Young Kim, Hyung

AU - Kwon, Ji Won

AU - Kim, Byoung Ju

AU - Kim, Hyo Bin

AU - Kim, Woo Kyung

AU - Lee, So Yeon

AU - Jang, Gwang Cheon

AU - Song, Dae Jin

AU - Kim, Ha Jung

AU - Shin, Yee Jin

AU - Park, Jung Won

AU - Cho, Sang Heon

AU - Lee, Joo Shil

AU - Hong, Soo Jong

PY - 2013/6/1

Y1 - 2013/6/1

N2 - Background Asthma is a chronic lower airway inflammatory disease. Nitric oxide is an inflammatory mediator produced endogenously in the airway. Previous studies have demonstrated that the fractional concentration of exhaled nitric oxide (FeNO) is increased in asthma. Objectives To investigate if FeNO concentrations were correlated with wheezing phenotypes in preschool children and to compare the FeNO results with airway hyperresponsiveness (AHR) and pulmonary function test (PFT) results. Methods We performed skin prick tests, methacholine provocation tests, PFT, impulse oscillometry bronchodilator response (IOS BDR) tests, and FeNO measurements in 372 preschool children between the ages of 4 and 6 years. Wheezing phenotypes were defined according to the age of onset and persistency. Results Persistent wheezers had higher FeNO levels than transient wheezers and non-wheezers. Among persistent wheezers, those with atopy and AHR had significantly higher FeNO levels than those without atopy or AHR. FeNO levels were significantly higher in late-onset wheezers than early-onset wheezers and non-wheezers. Among late-onset wheezers, those with atopy and AHR had a significantly higher FeNO concentration than those without atopy or AHR as well as those with either atopy or AHR. However, there were no significant differences in AHR, PFT, or IOS BDR between persistent and transient wheezers or between late-onset wheezers and early-onset wheezers. Conclusion FeNO may be a better marker for asthma phenotypes in preschool children than AHR and PFT results. Pediatr Pulmonol. 2013; 48:563-570. © 2012 Wiley Periodicals, Inc.

AB - Background Asthma is a chronic lower airway inflammatory disease. Nitric oxide is an inflammatory mediator produced endogenously in the airway. Previous studies have demonstrated that the fractional concentration of exhaled nitric oxide (FeNO) is increased in asthma. Objectives To investigate if FeNO concentrations were correlated with wheezing phenotypes in preschool children and to compare the FeNO results with airway hyperresponsiveness (AHR) and pulmonary function test (PFT) results. Methods We performed skin prick tests, methacholine provocation tests, PFT, impulse oscillometry bronchodilator response (IOS BDR) tests, and FeNO measurements in 372 preschool children between the ages of 4 and 6 years. Wheezing phenotypes were defined according to the age of onset and persistency. Results Persistent wheezers had higher FeNO levels than transient wheezers and non-wheezers. Among persistent wheezers, those with atopy and AHR had significantly higher FeNO levels than those without atopy or AHR. FeNO levels were significantly higher in late-onset wheezers than early-onset wheezers and non-wheezers. Among late-onset wheezers, those with atopy and AHR had a significantly higher FeNO concentration than those without atopy or AHR as well as those with either atopy or AHR. However, there were no significant differences in AHR, PFT, or IOS BDR between persistent and transient wheezers or between late-onset wheezers and early-onset wheezers. Conclusion FeNO may be a better marker for asthma phenotypes in preschool children than AHR and PFT results. Pediatr Pulmonol. 2013; 48:563-570. © 2012 Wiley Periodicals, Inc.

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Oh MA, Shim JY, Jung YH, Seo JH, Young Kim H, Kwon JW et al. Fraction of exhaled nitric oxide and wheezing phenotypes in preschool children. Pediatric Pulmonology. 2013 Jun 1;48(6):563-570. https://doi.org/10.1002/ppul.22705