Framingham risk score and risk of incident chronic kidney disease: A community-based prospective cohort study

Changhyun Lee, Hae Ryong Yun, Young Su Joo, Sangmi Lee, Joohwan Kim, Ki Heon Nam, Jong Hyun Jhee, Jung Tak Park, TaeHyun Yoo, Shin-Wook Kang, SeungHyeok Han

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Abstract

Background: Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the general population. Methods: This study included 9,080 subjects who participated in the Korean Genome and Epidemiology Study between 2001 and 2014 and had normal renal function. The subjects were classified into low-(< 10%), intermediate-(10-20%), and high-(> 20%) risk groups based on baseline Framingham risk scores. The primary endpoint was de novo chronic kidney disease development (estimated glomerular filtration rate [eGFR], < 60 mL/min/1.73 m2). Results: During a mean follow-up duration of 8.9 ± 4.3 years, 312 (5.3%), 217 (10.8%), and 205 (16.9%) subjects developed chronic kidney disease in the low, intermediate, and high risk groups, respectively (P < 0.001). Multivariable analysis after adjustment for confounding factors showed the hazard ratios for the high-and intermediate risk groups were 2.674 (95% confidence interval [CI], 2.197-3.255) and 1.734 (95% CI, 1.447-2.078), respectively. This association was consistently observed irrespective of proteinuria, age, sex, obesity, or hypertension. The predictive power of this scoring system was lower than that of renal parameters, such as eGFR and proteinuria, but increased when both were included in the prediction model. Conclusion: The Framingham risk score predicted incident chronic kidney disease and enhanced risk stratification in conjunction with traditional renal parameters in the general population with normal renal function.

Original languageEnglish
Pages (from-to)49-59
Number of pages11
JournalKidney Research and Clinical Practice
Volume38
Issue number1
DOIs
Publication statusPublished - 2019 Mar 1

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Chronic Renal Insufficiency
Cohort Studies
Prospective Studies
Kidney
Glomerular Filtration Rate
Proteinuria
Confidence Intervals
Population
Epidemiology
Cardiovascular Diseases
Obesity
Genome
Hypertension

All Science Journal Classification (ASJC) codes

  • Nephrology
  • Urology

Cite this

Lee, Changhyun ; Yun, Hae Ryong ; Joo, Young Su ; Lee, Sangmi ; Kim, Joohwan ; Nam, Ki Heon ; Jhee, Jong Hyun ; Park, Jung Tak ; Yoo, TaeHyun ; Kang, Shin-Wook ; Han, SeungHyeok. / Framingham risk score and risk of incident chronic kidney disease : A community-based prospective cohort study. In: Kidney Research and Clinical Practice. 2019 ; Vol. 38, No. 1. pp. 49-59.
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abstract = "Background: Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the general population. Methods: This study included 9,080 subjects who participated in the Korean Genome and Epidemiology Study between 2001 and 2014 and had normal renal function. The subjects were classified into low-(< 10{\%}), intermediate-(10-20{\%}), and high-(> 20{\%}) risk groups based on baseline Framingham risk scores. The primary endpoint was de novo chronic kidney disease development (estimated glomerular filtration rate [eGFR], < 60 mL/min/1.73 m2). Results: During a mean follow-up duration of 8.9 ± 4.3 years, 312 (5.3{\%}), 217 (10.8{\%}), and 205 (16.9{\%}) subjects developed chronic kidney disease in the low, intermediate, and high risk groups, respectively (P < 0.001). Multivariable analysis after adjustment for confounding factors showed the hazard ratios for the high-and intermediate risk groups were 2.674 (95{\%} confidence interval [CI], 2.197-3.255) and 1.734 (95{\%} CI, 1.447-2.078), respectively. This association was consistently observed irrespective of proteinuria, age, sex, obesity, or hypertension. The predictive power of this scoring system was lower than that of renal parameters, such as eGFR and proteinuria, but increased when both were included in the prediction model. Conclusion: The Framingham risk score predicted incident chronic kidney disease and enhanced risk stratification in conjunction with traditional renal parameters in the general population with normal renal function.",
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Framingham risk score and risk of incident chronic kidney disease : A community-based prospective cohort study. / Lee, Changhyun; Yun, Hae Ryong; Joo, Young Su; Lee, Sangmi; Kim, Joohwan; Nam, Ki Heon; Jhee, Jong Hyun; Park, Jung Tak; Yoo, TaeHyun; Kang, Shin-Wook; Han, SeungHyeok.

In: Kidney Research and Clinical Practice, Vol. 38, No. 1, 01.03.2019, p. 49-59.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Framingham risk score and risk of incident chronic kidney disease

T2 - A community-based prospective cohort study

AU - Lee, Changhyun

AU - Yun, Hae Ryong

AU - Joo, Young Su

AU - Lee, Sangmi

AU - Kim, Joohwan

AU - Nam, Ki Heon

AU - Jhee, Jong Hyun

AU - Park, Jung Tak

AU - Yoo, TaeHyun

AU - Kang, Shin-Wook

AU - Han, SeungHyeok

PY - 2019/3/1

Y1 - 2019/3/1

N2 - Background: Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the general population. Methods: This study included 9,080 subjects who participated in the Korean Genome and Epidemiology Study between 2001 and 2014 and had normal renal function. The subjects were classified into low-(< 10%), intermediate-(10-20%), and high-(> 20%) risk groups based on baseline Framingham risk scores. The primary endpoint was de novo chronic kidney disease development (estimated glomerular filtration rate [eGFR], < 60 mL/min/1.73 m2). Results: During a mean follow-up duration of 8.9 ± 4.3 years, 312 (5.3%), 217 (10.8%), and 205 (16.9%) subjects developed chronic kidney disease in the low, intermediate, and high risk groups, respectively (P < 0.001). Multivariable analysis after adjustment for confounding factors showed the hazard ratios for the high-and intermediate risk groups were 2.674 (95% confidence interval [CI], 2.197-3.255) and 1.734 (95% CI, 1.447-2.078), respectively. This association was consistently observed irrespective of proteinuria, age, sex, obesity, or hypertension. The predictive power of this scoring system was lower than that of renal parameters, such as eGFR and proteinuria, but increased when both were included in the prediction model. Conclusion: The Framingham risk score predicted incident chronic kidney disease and enhanced risk stratification in conjunction with traditional renal parameters in the general population with normal renal function.

AB - Background: Cardiovascular disease and chronic kidney disease share several common risk factors. The Framingham risk score is hypothesized to predict chronic kidney disease development. We determined if the Framingham risk scoring system can correctly predict incident chronic kidney disease in the general population. Methods: This study included 9,080 subjects who participated in the Korean Genome and Epidemiology Study between 2001 and 2014 and had normal renal function. The subjects were classified into low-(< 10%), intermediate-(10-20%), and high-(> 20%) risk groups based on baseline Framingham risk scores. The primary endpoint was de novo chronic kidney disease development (estimated glomerular filtration rate [eGFR], < 60 mL/min/1.73 m2). Results: During a mean follow-up duration of 8.9 ± 4.3 years, 312 (5.3%), 217 (10.8%), and 205 (16.9%) subjects developed chronic kidney disease in the low, intermediate, and high risk groups, respectively (P < 0.001). Multivariable analysis after adjustment for confounding factors showed the hazard ratios for the high-and intermediate risk groups were 2.674 (95% confidence interval [CI], 2.197-3.255) and 1.734 (95% CI, 1.447-2.078), respectively. This association was consistently observed irrespective of proteinuria, age, sex, obesity, or hypertension. The predictive power of this scoring system was lower than that of renal parameters, such as eGFR and proteinuria, but increased when both were included in the prediction model. Conclusion: The Framingham risk score predicted incident chronic kidney disease and enhanced risk stratification in conjunction with traditional renal parameters in the general population with normal renal function.

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