Frequent visualization of thyroglossal duct remnant on post-ablation 131I-SPECT/CT and its clinical implications

M. Lee, Y. K. Lee, T. J. Jeon, H. S. Chang, B. W. Kim, Y. S. Lee, C. S. Park, Y. H. Ryu

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Aim To evaluate the frequency of thyroglossal duct remnant (TGDR) uptake on post-therapy 131I-scintigraphy in thyroid cancer patients, to analyse the rate of persistent TGDR uptake on follow-up combined 131I-single-photon emission CT/CT (SPECT/CT), and to identify the differential clinical characteristics between patients with positive and negative TGDR uptake on 131I-SPECT/CT. Materials and methods A total of 179 patients treated with total thyroidectomy for thyroid cancer were enrolled in the study. At 131I-whole-body scan (WBS), TGDR uptake was defined as an increase in radioactivity at the midline of the neck versus the thyroid bed. TGDR uptake on 131I- SPECT/CT was defined as the presence of radioactivity at the expected pathway of the thyroglossal duct without evidence of metastatic foci. Persistent TGDR uptake was confirmed when TGDR uptake on follow-up 131I-SPECT/CT corresponded to previous TGDR uptake detected by post-therapy 131I-SPECT/CT. Results At SPECT/CT, TGDR uptake was noted in 86 of 179 patients. Stimulated thyroglobulin (sTg) levels were significantly higher (p = 0.02) in patients with positive TGDR uptake. Persistent TGDR uptake on follow-up 131I-SPECT/CT was noted in 15 of 86 patients; sTg levels were significantly higher (p = 0.03) in the patients with persistent TGDR uptake. Conclusion TGDR uptake is frequently visualized on post-therapy 131I-SPECT/CT images and can be resistant to 131I ablation. TGDR uptake has the potential to result in an elevation of serum thyroglobulin levels. 131I-SPECT/CT clarifies TGDR uptake without additional invasive procedures or imaging studies, eliminating confusion among clinicians for managing differentiated thyroid cancer patients.

Original languageEnglish
Pages (from-to)638-643
Number of pages6
JournalClinical Radiology
Volume70
Issue number6
DOIs
Publication statusPublished - 2015 Jun 1

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Photons
Thyroglobulin
Thyroid Neoplasms
Radioactivity
Whole Body Imaging
Thyroidectomy
Radionuclide Imaging
Thyroid Gland
Neck
Therapeutics
Serum

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Lee, M. ; Lee, Y. K. ; Jeon, T. J. ; Chang, H. S. ; Kim, B. W. ; Lee, Y. S. ; Park, C. S. ; Ryu, Y. H. / Frequent visualization of thyroglossal duct remnant on post-ablation 131I-SPECT/CT and its clinical implications. In: Clinical Radiology. 2015 ; Vol. 70, No. 6. pp. 638-643.
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title = "Frequent visualization of thyroglossal duct remnant on post-ablation 131I-SPECT/CT and its clinical implications",
abstract = "Aim To evaluate the frequency of thyroglossal duct remnant (TGDR) uptake on post-therapy 131I-scintigraphy in thyroid cancer patients, to analyse the rate of persistent TGDR uptake on follow-up combined 131I-single-photon emission CT/CT (SPECT/CT), and to identify the differential clinical characteristics between patients with positive and negative TGDR uptake on 131I-SPECT/CT. Materials and methods A total of 179 patients treated with total thyroidectomy for thyroid cancer were enrolled in the study. At 131I-whole-body scan (WBS), TGDR uptake was defined as an increase in radioactivity at the midline of the neck versus the thyroid bed. TGDR uptake on 131I- SPECT/CT was defined as the presence of radioactivity at the expected pathway of the thyroglossal duct without evidence of metastatic foci. Persistent TGDR uptake was confirmed when TGDR uptake on follow-up 131I-SPECT/CT corresponded to previous TGDR uptake detected by post-therapy 131I-SPECT/CT. Results At SPECT/CT, TGDR uptake was noted in 86 of 179 patients. Stimulated thyroglobulin (sTg) levels were significantly higher (p = 0.02) in patients with positive TGDR uptake. Persistent TGDR uptake on follow-up 131I-SPECT/CT was noted in 15 of 86 patients; sTg levels were significantly higher (p = 0.03) in the patients with persistent TGDR uptake. Conclusion TGDR uptake is frequently visualized on post-therapy 131I-SPECT/CT images and can be resistant to 131I ablation. TGDR uptake has the potential to result in an elevation of serum thyroglobulin levels. 131I-SPECT/CT clarifies TGDR uptake without additional invasive procedures or imaging studies, eliminating confusion among clinicians for managing differentiated thyroid cancer patients.",
author = "M. Lee and Lee, {Y. K.} and Jeon, {T. J.} and Chang, {H. S.} and Kim, {B. W.} and Lee, {Y. S.} and Park, {C. S.} and Ryu, {Y. H.}",
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Frequent visualization of thyroglossal duct remnant on post-ablation 131I-SPECT/CT and its clinical implications. / Lee, M.; Lee, Y. K.; Jeon, T. J.; Chang, H. S.; Kim, B. W.; Lee, Y. S.; Park, C. S.; Ryu, Y. H.

In: Clinical Radiology, Vol. 70, No. 6, 01.06.2015, p. 638-643.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Frequent visualization of thyroglossal duct remnant on post-ablation 131I-SPECT/CT and its clinical implications

AU - Lee, M.

AU - Lee, Y. K.

AU - Jeon, T. J.

AU - Chang, H. S.

AU - Kim, B. W.

AU - Lee, Y. S.

AU - Park, C. S.

AU - Ryu, Y. H.

PY - 2015/6/1

Y1 - 2015/6/1

N2 - Aim To evaluate the frequency of thyroglossal duct remnant (TGDR) uptake on post-therapy 131I-scintigraphy in thyroid cancer patients, to analyse the rate of persistent TGDR uptake on follow-up combined 131I-single-photon emission CT/CT (SPECT/CT), and to identify the differential clinical characteristics between patients with positive and negative TGDR uptake on 131I-SPECT/CT. Materials and methods A total of 179 patients treated with total thyroidectomy for thyroid cancer were enrolled in the study. At 131I-whole-body scan (WBS), TGDR uptake was defined as an increase in radioactivity at the midline of the neck versus the thyroid bed. TGDR uptake on 131I- SPECT/CT was defined as the presence of radioactivity at the expected pathway of the thyroglossal duct without evidence of metastatic foci. Persistent TGDR uptake was confirmed when TGDR uptake on follow-up 131I-SPECT/CT corresponded to previous TGDR uptake detected by post-therapy 131I-SPECT/CT. Results At SPECT/CT, TGDR uptake was noted in 86 of 179 patients. Stimulated thyroglobulin (sTg) levels were significantly higher (p = 0.02) in patients with positive TGDR uptake. Persistent TGDR uptake on follow-up 131I-SPECT/CT was noted in 15 of 86 patients; sTg levels were significantly higher (p = 0.03) in the patients with persistent TGDR uptake. Conclusion TGDR uptake is frequently visualized on post-therapy 131I-SPECT/CT images and can be resistant to 131I ablation. TGDR uptake has the potential to result in an elevation of serum thyroglobulin levels. 131I-SPECT/CT clarifies TGDR uptake without additional invasive procedures or imaging studies, eliminating confusion among clinicians for managing differentiated thyroid cancer patients.

AB - Aim To evaluate the frequency of thyroglossal duct remnant (TGDR) uptake on post-therapy 131I-scintigraphy in thyroid cancer patients, to analyse the rate of persistent TGDR uptake on follow-up combined 131I-single-photon emission CT/CT (SPECT/CT), and to identify the differential clinical characteristics between patients with positive and negative TGDR uptake on 131I-SPECT/CT. Materials and methods A total of 179 patients treated with total thyroidectomy for thyroid cancer were enrolled in the study. At 131I-whole-body scan (WBS), TGDR uptake was defined as an increase in radioactivity at the midline of the neck versus the thyroid bed. TGDR uptake on 131I- SPECT/CT was defined as the presence of radioactivity at the expected pathway of the thyroglossal duct without evidence of metastatic foci. Persistent TGDR uptake was confirmed when TGDR uptake on follow-up 131I-SPECT/CT corresponded to previous TGDR uptake detected by post-therapy 131I-SPECT/CT. Results At SPECT/CT, TGDR uptake was noted in 86 of 179 patients. Stimulated thyroglobulin (sTg) levels were significantly higher (p = 0.02) in patients with positive TGDR uptake. Persistent TGDR uptake on follow-up 131I-SPECT/CT was noted in 15 of 86 patients; sTg levels were significantly higher (p = 0.03) in the patients with persistent TGDR uptake. Conclusion TGDR uptake is frequently visualized on post-therapy 131I-SPECT/CT images and can be resistant to 131I ablation. TGDR uptake has the potential to result in an elevation of serum thyroglobulin levels. 131I-SPECT/CT clarifies TGDR uptake without additional invasive procedures or imaging studies, eliminating confusion among clinicians for managing differentiated thyroid cancer patients.

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