From cell biology to immunology: Controlling metastatic progression of cancer via microRNA regulatory networks

Jae Hyon Park, Evropi Theodoratou, George A. Calin, Jae Il Shin

Research output: Contribution to journalReview article

4 Citations (Scopus)

Abstract

Recently, the study of microRNAs has expanded our knowledge of the fundamental processes of cancer biology and the underlying mechanisms behind tumor metastasis. Extensive research in the fields of microRNA and its novel mechanisms of actions against various cancers has more recently led to the trial of a first cancer-targeted microRNA drug, MRX34. Yet, these microRNAs are mostly being studied and clinically trialed solely based on the understanding of their cell biologic effects, thus, neglecting the important immunologic effects that are sometimes opposite of the cell biologic effects. Here, we summarize both the cell biologic and immunologic effects of various microRNAs and discuss the importance of considering both effects before using them in clinical settings. We stress the importance of understanding the miRNA's effect on cancer metastasis from a “systems” perspective before developing a miRNA-targeted therapeutic in treating cancer metastasis.

Original languageEnglish
Article numbere1230579
JournalOncoImmunology
Volume5
Issue number11
DOIs
Publication statusPublished - 2016 Nov 1

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Allergy and Immunology
MicroRNAs
Cell Biology
Neoplasms
Neoplasm Metastasis
Research
Pharmaceutical Preparations

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology
  • Oncology

Cite this

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abstract = "Recently, the study of microRNAs has expanded our knowledge of the fundamental processes of cancer biology and the underlying mechanisms behind tumor metastasis. Extensive research in the fields of microRNA and its novel mechanisms of actions against various cancers has more recently led to the trial of a first cancer-targeted microRNA drug, MRX34. Yet, these microRNAs are mostly being studied and clinically trialed solely based on the understanding of their cell biologic effects, thus, neglecting the important immunologic effects that are sometimes opposite of the cell biologic effects. Here, we summarize both the cell biologic and immunologic effects of various microRNAs and discuss the importance of considering both effects before using them in clinical settings. We stress the importance of understanding the miRNA's effect on cancer metastasis from a “systems” perspective before developing a miRNA-targeted therapeutic in treating cancer metastasis.",
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From cell biology to immunology : Controlling metastatic progression of cancer via microRNA regulatory networks. / Park, Jae Hyon; Theodoratou, Evropi; Calin, George A.; Shin, Jae Il.

In: OncoImmunology, Vol. 5, No. 11, e1230579, 01.11.2016.

Research output: Contribution to journalReview article

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