Frontiers in Probing Alzheimer's Disease Biomarkers with Fluorescent Small Molecules

Yong Woong Jun, Seo Won Cho, Junyang Jung, Youngbuhm Huh, YoungSoo Kim, Dokyoung Kim, Kyo Han Ahn

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

Alzheimer's disease (AD) is the most common form of dementia. The pathogenesis of the disease is associated with aggregated amyloid-β, hyperphosphorylated tau, a high level of metal ions, abnormal enzyme activities, and reactive astrocytes. This outlook gives an overview of fluorescent small molecules targeting AD biomarkers for ex vivo and in vivo imaging. These chemical imaging probes are categorized based on the potential biomarkers, and their pros and cons are discussed. Guidelines for designing new sensing strategies as well as the desirable properties to be pursued for AD fluorescence imaging are also provided.

Original languageEnglish
Pages (from-to)209-217
Number of pages9
JournalACS Central Science
Volume5
Issue number2
DOIs
Publication statusPublished - 2019 Feb 27

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Biomarkers
Molecules
Imaging techniques
Enzyme activity
Amyloid
Metal ions
Fluorescence

Cite this

Jun, Yong Woong ; Cho, Seo Won ; Jung, Junyang ; Huh, Youngbuhm ; Kim, YoungSoo ; Kim, Dokyoung ; Ahn, Kyo Han. / Frontiers in Probing Alzheimer's Disease Biomarkers with Fluorescent Small Molecules. In: ACS Central Science. 2019 ; Vol. 5, No. 2. pp. 209-217.
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Frontiers in Probing Alzheimer's Disease Biomarkers with Fluorescent Small Molecules. / Jun, Yong Woong; Cho, Seo Won; Jung, Junyang; Huh, Youngbuhm; Kim, YoungSoo; Kim, Dokyoung; Ahn, Kyo Han.

In: ACS Central Science, Vol. 5, No. 2, 27.02.2019, p. 209-217.

Research output: Contribution to journalReview article

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AU - Jun, Yong Woong

AU - Cho, Seo Won

AU - Jung, Junyang

AU - Huh, Youngbuhm

AU - Kim, YoungSoo

AU - Kim, Dokyoung

AU - Ahn, Kyo Han

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