Fucoidan inhibits UVB-induced MMP-I promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts

Hee Jung Moon, Sang Ho Lee, Mi Jeong Ku, Byeng Chul Yu, Man Joong Jeon, Seok Hoon Jeong, Valentin A. Stonil, Tatyana N. Zvyagintseva, Světlana P. Ermakova, Yong Hwan Lee

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Abstract

UVB reduces type I procollagen levels and increases matrix metalloproteinases-1 (MMP-I) levels in human skin and plays a major role in the process of photoaging. We previously reported that fucoidan inhibits UVB-induced MMP-I expression at the protein and mRNA levels in human skin fibroblasts (HS68). Yet, the effects of fucoidan on UVB-induced MMP-I promoter activity and type I pro-collagen have not been investigated. In this study, we assessed the effects of fucoidan on the inhibition of MMP-I promoter activity and on the increase of type I procollagen synthesis in human skin fibro-blasts. Fucoidan treatment significantly inhibited MMP-I promoter activity compared to UVB irradiation alone. Fucoidan treatment also increased type I procollagen mRNA and protein expression in a dose-dependent manner compared to the control. Our data indicate that fucoidan may prevent UVB-induced MMP-I expression and inhibit down-regulation of type I procollagen synthesis. We suggest that fucoidan may be a potential therapeutic agent to prevent and treat skin photoaging.

Original languageEnglish
Pages (from-to)129-134
Number of pages6
JournalEuropean Journal of Dermatology
Volume19
Issue number2
DOIs
Publication statusPublished - 2009 Mar

All Science Journal Classification (ASJC) codes

  • Dermatology

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    Moon, H. J., Lee, S. H., Ku, M. J., Yu, B. C., Jeon, M. J., Jeong, S. H., Stonil, V. A., Zvyagintseva, T. N., Ermakova, S. P., & Lee, Y. H. (2009). Fucoidan inhibits UVB-induced MMP-I promoter expression and down regulation of type I procollagen synthesis in human skin fibroblasts. European Journal of Dermatology, 19(2), 129-134. https://doi.org/10.1684/ejd.2008.0611