Fully automated hybrid approach to predict the IDH mutation status of gliomas via deep learning and radiomics

Yoon Seong Choi, Sohi Bae, Jong Hee Chang, Seok Gu Kang, Se Hoon Kim, Jinna Kim, Tyler Hyungtaek Rim, Seung Hong Choi, Rajan Jain, Seung Koo Lee

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

Background: Glioma prognosis depends on isocitrate dehydrogenase (IDH) mutation status. We aimed to predict the IDH status of gliomas from preoperative MR images using a fully automated hybrid approach with convolutional neural networks (CNNs) and radiomics. Methods: We reviewed 1166 preoperative MR images of gliomas (grades II-IV) from Severance Hospital (n = 856), Seoul National University Hospital (SNUH; n = 107), and The Cancer Imaging Archive (TCIA; n = 203). The Severance set was subdivided into the development (n = 727) and internal test (n = 129) sets. Based on T1 postcontrast, T2, and fluid-attenuated inversion recovery images, a fully automated model was developed that comprised a CNN for tumor segmentation (Model 1) and CNN-based classifier for IDH status prediction (Model 2) that uses a hybrid approach based on 2D tumor images and radiomic features from 3D tumor shape and loci guided by Model 1. The trained model was tested on internal (a subset of the Severance set) and external (SNUH and TCIA) test sets. Results: The CNN for tumor segmentation (Model 1) achieved a dice coefficient of 0.86-0.92 across datasets. Our hybrid model achieved accuracies of 93.8%, 87.9%, and 78.8%, with areas under the receiver operating characteristic curves of 0.96, 0.94, and 0.86 and areas under the precision-recall curves of 0.88, 0.82, and 0.81 in the internal test, SNUH, and TCIA sets, respectively. Conclusions: Our fully automated hybrid model demonstrated the potential to be a highly reproducible and generalizable tool across different datasets for the noninvasive prediction of the IDH status of gliomas.

Original languageEnglish
Pages (from-to)304-313
Number of pages10
JournalNeuro-Oncology
Volume23
Issue number2
DOIs
Publication statusPublished - 2021 Feb 1

Bibliographical note

Publisher Copyright:
© 2020 The Author(s) 2020. Published by Oxford University Press on behalf of the Society for Neuro-Oncology. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

All Science Journal Classification (ASJC) codes

  • Oncology
  • Clinical Neurology
  • Cancer Research

Fingerprint Dive into the research topics of 'Fully automated hybrid approach to predict the IDH mutation status of gliomas via deep learning and radiomics'. Together they form a unique fingerprint.

Cite this