Fulminant epstein-barr virus-associated T-cell lymphoproliferative disorder in an immunocompetent middle-aged man presenting with chronic diarrhea and gastrointestinal bleeding

Jamshid Abdul-Ghafar, Jae Woo Kim, Kwang Hwa Park, Mee Yon Cho

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The World Health Organization (WHO) recently defined systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disorders (LPD) of childhood as a life-threatening illness. However, this rare disease has not been extensively studied. Here we report a case of systemic EBV-positive T-cell LPD in a previously healthy middle-aged man with a chief complaint of chronic diarrhea. The initial colon biopsy showed focal infiltration of EBVpositive small lymphocytes without any atypia. However, the disease rapidly progressed and the patient required a total colectomy due to severe gastrointestinal bleeding. Three and half months after admission, the patient died from a complication of disseminated intravascular coagulation. The resected colon showed diffuse infiltration of EBV-positive atypical lymphocytes with ischemic change. Most atypical lymphocytes were CD3+ or CD5+. The monoclonality of EBV was demonstrated by sequence variation analysis of the latent membrane protein 1 (LMP1) gene in the colectomy specimen as well as in the initial biopsy.

Original languageEnglish
Pages (from-to)1103-1107
Number of pages5
JournalJournal of Korean medical science
Volume26
Issue number8
DOIs
Publication statusPublished - 2011 Aug 1

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Lymphoproliferative Disorders
Human Herpesvirus 4
Diarrhea
Hemorrhage
T-Lymphocytes
Colectomy
Lymphocytes
Colon
Biopsy
Disseminated Intravascular Coagulation
Patient Admission
Rare Diseases
Sequence Analysis
Membrane Proteins
Genes

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

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abstract = "The World Health Organization (WHO) recently defined systemic Epstein-Barr virus (EBV)-positive T-cell lymphoproliferative disorders (LPD) of childhood as a life-threatening illness. However, this rare disease has not been extensively studied. Here we report a case of systemic EBV-positive T-cell LPD in a previously healthy middle-aged man with a chief complaint of chronic diarrhea. The initial colon biopsy showed focal infiltration of EBVpositive small lymphocytes without any atypia. However, the disease rapidly progressed and the patient required a total colectomy due to severe gastrointestinal bleeding. Three and half months after admission, the patient died from a complication of disseminated intravascular coagulation. The resected colon showed diffuse infiltration of EBV-positive atypical lymphocytes with ischemic change. Most atypical lymphocytes were CD3+ or CD5+. The monoclonality of EBV was demonstrated by sequence variation analysis of the latent membrane protein 1 (LMP1) gene in the colectomy specimen as well as in the initial biopsy.",
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Fulminant epstein-barr virus-associated T-cell lymphoproliferative disorder in an immunocompetent middle-aged man presenting with chronic diarrhea and gastrointestinal bleeding. / Abdul-Ghafar, Jamshid; Kim, Jae Woo; Park, Kwang Hwa; Cho, Mee Yon.

In: Journal of Korean medical science, Vol. 26, No. 8, 01.08.2011, p. 1103-1107.

Research output: Contribution to journalArticle

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