Function and regulation of Dyrk1A

towards understanding Down syndrome.

Joongkyu Park, Woo Joo Song, Kwang Chul Chung

Research output: Contribution to journalReview article

110 Citations (Scopus)

Abstract

Down syndrome (DS) is associated with a variety of symptoms, such as incapacitating mental retardation and neurodegeneration (i.e., Alzheimer's disease), that prevent patients from leading fully independent lives. These phenotypes are a direct consequence of the overexpression of chromosome 21 genes, which are present in duplicate due to non-disjunction of chromosome 21. Accumulating data suggest that the chromosome 21 gene product, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (Dyrk1A), participates in the pathogenic mechanisms underlying the mental and other physical symptoms of DS. In this review, we summarize the evidence supporting a role for Dyrk1A in DS, especially DS pathogenesis. Recently, several natural and synthetic compounds have been identified as Dyrk1A inhibitors. Understanding the function and regulation of Dyrk1A may lead to the development of novel therapeutic agents aimed at treating DS.

Original languageEnglish
Pages (from-to)3235-3240
Number of pages6
JournalCellular and molecular life sciences : CMLS
Volume66
Issue number20
DOIs
Publication statusPublished - 2009 Jan 1

Fingerprint

Down Syndrome
Chromosomes, Human, Pair 21
Intellectual Disability
Genes
Alzheimer Disease
Phenotype
Therapeutics

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Cellular and Molecular Neuroscience
  • Cell Biology

Cite this

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abstract = "Down syndrome (DS) is associated with a variety of symptoms, such as incapacitating mental retardation and neurodegeneration (i.e., Alzheimer's disease), that prevent patients from leading fully independent lives. These phenotypes are a direct consequence of the overexpression of chromosome 21 genes, which are present in duplicate due to non-disjunction of chromosome 21. Accumulating data suggest that the chromosome 21 gene product, dual-specificity tyrosine-(Y)-phosphorylation regulated kinase 1A (Dyrk1A), participates in the pathogenic mechanisms underlying the mental and other physical symptoms of DS. In this review, we summarize the evidence supporting a role for Dyrk1A in DS, especially DS pathogenesis. Recently, several natural and synthetic compounds have been identified as Dyrk1A inhibitors. Understanding the function and regulation of Dyrk1A may lead to the development of novel therapeutic agents aimed at treating DS.",
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Function and regulation of Dyrk1A : towards understanding Down syndrome. / Park, Joongkyu; Song, Woo Joo; Chung, Kwang Chul.

In: Cellular and molecular life sciences : CMLS, Vol. 66, No. 20, 01.01.2009, p. 3235-3240.

Research output: Contribution to journalReview article

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