Function of membranous lysyl-tRNA synthetase and its implication for tumorigenesis

Ho Jeon Young, Jung Weon Lee, Sunghoon Kim

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Aminoacyl-tRNA synthetases (ARSs) are essential enzymes that conjugate specific amino acids to their cognate tRNAs for protein synthesis. Besides their catalytic activity, recent studies have uncovered many additional functions of these enzymes through their interactions with diverse cellular factors. Among human ARSs, cytosolic lysyl-tRNA synthetase (KRS) is often highly expressed in cancer cells and tissues, and facilitates cancer cell migration and invasion through the interaction with the 67 kDa laminin receptor on the plasma membrane. Specific modulation of this interaction by small molecule inhibitors has revealed a new way to control metastasis. Here, we summarize the pro-metastatic functions of KRS and their patho-physiological implications.

Original languageEnglish
Pages (from-to)1707-1713
Number of pages7
JournalBiochimica et Biophysica Acta - Proteins and Proteomics
Volume1864
Issue number12
DOIs
Publication statusPublished - 2016 Dec 1

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Biophysics
  • Biochemistry
  • Molecular Biology

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