Functional connectivity of the circadian clock and neural substrates of sleep-wake disturbance in delirium

Sunghyon Kyeong, Soo Hee Choi, Jung Eun Shin, Woo Suk Lee, Kyu Hyun Yang, Tae Sub Chung, Jae Jin Kim

Research output: Contribution to journalArticle

4 Citations (Scopus)


A possible mechanism of disrupted circadian rhythms in delirium was identified using resting-state functional connectivity. Thirty-four delirious patients and 38 non-delirious controls were scanned for resting-state functional MRI. Seed-based connectivity of the suprachiasmatic nucleus was compared between the groups. In delirious patients functional connectivity from the circadian clock was increased to the dorsal anterior cingulate cortex and decreased to the posterior cingulate cortex, parahippocampal gyrus, cerebellum, and thalamus. A dysregulation of the default mode network and mental coordination processing areas by the circadian clock may be the underlying pathophysiology of sleep-wake cycle disturbance and symptom fluctuation in delirium.

Original languageEnglish
Pages (from-to)10-12
Number of pages3
JournalPsychiatry Research - Neuroimaging
Publication statusPublished - 2017 Jun 30


All Science Journal Classification (ASJC) codes

  • Neuroscience (miscellaneous)
  • Radiology Nuclear Medicine and imaging
  • Psychiatry and Mental health

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