Functional disconnection between the prefrontal and parietal cortices during working memory processing in schizophrenia: A [15O]H 2O PET study

Jae Jin Kim, Jun Soo Kwon, Jeong Park Hae, Tak Youn, Hyung Kang Do, Sun Kim Myung, Soo Lee Dong, Chul Lee Myung

Research output: Contribution to journalArticle

123 Citations (Scopus)

Abstract

Objective: The prefrontal-parietal circuits have been reported to play an important role in working memory. The purpose of this study was to use direct neuroimaging to address whether interregional correlation in the prefrontal-parietal circuits is impaired in schizophrenia. Method: [ 15O]H2O positron emission tomography was used to compare regional blood flow changes in 12 schizophrenic and 12 healthy comparison subjects during the n-back sequential-picture working memory task. Interregional correlation was assessed by correlating the regional activation of the lateral prefrontal area with that of other activated areas in each subject group. Results: Dorsolateral prefrontal activation was observed around the right superior frontal sulcus in the healthy subjects, and ventrolateral prefrontal activation below the right inferior frontal sulcus was observed in the schizophrenic patients. Activation in the right lateral prefrontal cortex was significantly correlated with activation in the bilateral inferior parietal region in the healthy subjects but was not correlated with any regional activation in the patients. Conclusions: The findings suggest prefrontal-parietal functional disconnection, particularly prefrontal dissociation and abnormal prefrontal-parietal interaction, during working memory processing in schizophrenia.

Original languageEnglish
Pages (from-to)919-923
Number of pages5
JournalAmerican Journal of Psychiatry
Volume160
Issue number5
DOIs
Publication statusPublished - 2003 May 1

All Science Journal Classification (ASJC) codes

  • Psychiatry and Mental health

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