Functional electrical stimulation exercise increases GLUT-1 and GLUT-4 in paralyzed skeletal muscle

Philip D. Chilibeck, Gordon Bell, Justin Jeon, Christina B. Weiss, Gordon Murdoch, Ian MacLean, Edmond Ryan, Robert Burnham

Research output: Contribution to journalArticle

61 Citations (Scopus)

Abstract

The study purpose was to determine the effect of functional electrical stimulation (FES)-leg cycle ergometer training (30 minutes on 3 d/wk for 8 weeks) on the GLUT-1 and GLUT-4 content of paralyzed skeletal muscle. Biopsy samples of vastus lateralis muscle were obtained pre- and post-training from five individuals with motor-complete spinal cord injury ([SCI] four men and one woman aged 31 to 50 years, 3 to 25 years postinjury involving C5-T8). Western blot analysis indicated that GLUT-1 increased by 52% and GLUT-4 increased by 72% with training (P < .05). This coincided with an increase in the muscle oxidative capacity as indicated by a 56% increase in citrate synthase (CS) activity (P < .05) and an improvement in the insulin sensitivity index as determined from oral glucose tolerance tests (P < .05). It is concluded that FES endurance training is effective to increase glucose transporter protein levels in paralyzed skeletal muscle of individuals with SCI.

Original languageEnglish
Pages (from-to)1409-1413
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume48
Issue number11
DOIs
Publication statusPublished - 1999 Jan 1

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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