Functional electrical stimulation exercise increases GLUT-1 and GLUT-4 in paralyzed skeletal muscle

Philip D. Chilibeck, Gordon Bell, Justin Y. Jeon, Christina B. Weiss, Gordon Murdoch, Ian MacLean, Edmond Ryan, Robert Burnham

Research output: Contribution to journalArticle

59 Citations (Scopus)

Abstract

The study purpose was to determine the effect of functional electrical stimulation (FES)-leg cycle ergometer training (30 minutes on 3 d/wk for 8 weeks) on the GLUT-1 and GLUT-4 content of paralyzed skeletal muscle. Biopsy samples of vastus lateralis muscle were obtained pre- and post-training from five individuals with motor-complete spinal cord injury ([SCI] four men and one woman aged 31 to 50 years, 3 to 25 years postinjury involving C5-T8). Western blot analysis indicated that GLUT-1 increased by 52% and GLUT-4 increased by 72% with training (P < .05). This coincided with an increase in the muscle oxidative capacity as indicated by a 56% increase in citrate synthase (CS) activity (P < .05) and an improvement in the insulin sensitivity index as determined from oral glucose tolerance tests (P < .05). It is concluded that FES endurance training is effective to increase glucose transporter protein levels in paralyzed skeletal muscle of individuals with SCI.

Original languageEnglish
Pages (from-to)1409-1413
Number of pages5
JournalMetabolism: Clinical and Experimental
Volume48
Issue number11
DOIs
Publication statusPublished - 1999 Jan 1

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Spinal Cord Injuries
Electric Stimulation
Skeletal Muscle
Exercise
Citrate (si)-Synthase
Muscles
Facilitative Glucose Transport Proteins
Quadriceps Muscle
Glucose Tolerance Test
Insulin Resistance
Leg
Western Blotting
Biopsy
Proteins

All Science Journal Classification (ASJC) codes

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

Cite this

Chilibeck, Philip D. ; Bell, Gordon ; Jeon, Justin Y. ; Weiss, Christina B. ; Murdoch, Gordon ; MacLean, Ian ; Ryan, Edmond ; Burnham, Robert. / Functional electrical stimulation exercise increases GLUT-1 and GLUT-4 in paralyzed skeletal muscle. In: Metabolism: Clinical and Experimental. 1999 ; Vol. 48, No. 11. pp. 1409-1413.
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Functional electrical stimulation exercise increases GLUT-1 and GLUT-4 in paralyzed skeletal muscle. / Chilibeck, Philip D.; Bell, Gordon; Jeon, Justin Y.; Weiss, Christina B.; Murdoch, Gordon; MacLean, Ian; Ryan, Edmond; Burnham, Robert.

In: Metabolism: Clinical and Experimental, Vol. 48, No. 11, 01.01.1999, p. 1409-1413.

Research output: Contribution to journalArticle

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