Functional inhibition of UQCRB suppresses angiogenesis in zebrafish

Yoon Sun Cho; Hye Jin Jung; Seung Hyeok Seok; Alexander Y. Payumo; James K. Chen; Ho Jeong Kwon

doi:10.1016/j.bbrc.2013.02.082

Functional inhibition of UQCRB suppresses angiogenesis in zebrafish

Yoon Sun Cho, Hye Jin Jung, Seung Hyeok Seok, Alexander Y. Payumo, James K. Chen, Ho Jeong Kwon

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.

Original language	English
Pages (from-to)	396-400
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	433
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2013.02.082
Publication status	Published - 2013 Apr 19

Bibliographical note

Funding Information:
This study was partly supported by Grants from the National Research Foundation (NRF) of Korea , the Korean Government ( MEST ; 2009-0092964 , 2010-0017984 , 2012M3A9D1054520 ), the Translational Research Center for Protein Function Control and the National Junior Research Fellowship , NRF ( 2009-0083522 , 2011-006165 ), the Center for Food and Drug Materials of Agriculture Science & Technology Development ( PJ0079772012 ), the Rural Development Administration , and the Brain Korea 21 Project, and the National Institutes of Health ( DP1 HD075622 to J.K.C.).

All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Access to Document

10.1016/j.bbrc.2013.02.082

Fingerprint Dive into the research topics of 'Functional inhibition of UQCRB suppresses angiogenesis in zebrafish'. Together they form a unique fingerprint.

Cite this

@article{aad34228bd794593a8cd1919f9b63c0c,

title = "Functional inhibition of UQCRB suppresses angiogenesis in zebrafish",

abstract = "As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.",

author = "Cho, {Yoon Sun} and Jung, {Hye Jin} and Seok, {Seung Hyeok} and Payumo, {Alexander Y.} and Chen, {James K.} and Kwon, {Ho Jeong}",

note = "Funding Information: This study was partly supported by Grants from the National Research Foundation (NRF) of Korea , the Korean Government ( MEST ; 2009-0092964 , 2010-0017984 , 2012M3A9D1054520 ), the Translational Research Center for Protein Function Control and the National Junior Research Fellowship , NRF ( 2009-0083522 , 2011-006165 ), the Center for Food and Drug Materials of Agriculture Science & Technology Development ( PJ0079772012 ), the Rural Development Administration , and the Brain Korea 21 Project, and the National Institutes of Health ( DP1 HD075622 to J.K.C.).",

year = "2013",

month = apr,

day = "19",

doi = "10.1016/j.bbrc.2013.02.082",

language = "English",

volume = "433",

pages = "396--400",

journal = "Biochemical and Biophysical Research Communications",

issn = "0006-291X",

publisher = "Academic Press Inc.",

number = "4",

}

TY - JOUR

T1 - Functional inhibition of UQCRB suppresses angiogenesis in zebrafish

AU - Cho, Yoon Sun

AU - Jung, Hye Jin

AU - Seok, Seung Hyeok

AU - Payumo, Alexander Y.

AU - Chen, James K.

AU - Kwon, Ho Jeong

N1 - Funding Information: This study was partly supported by Grants from the National Research Foundation (NRF) of Korea , the Korean Government ( MEST ; 2009-0092964 , 2010-0017984 , 2012M3A9D1054520 ), the Translational Research Center for Protein Function Control and the National Junior Research Fellowship , NRF ( 2009-0083522 , 2011-006165 ), the Center for Food and Drug Materials of Agriculture Science & Technology Development ( PJ0079772012 ), the Rural Development Administration , and the Brain Korea 21 Project, and the National Institutes of Health ( DP1 HD075622 to J.K.C.).

PY - 2013/4/19

Y1 - 2013/4/19

N2 - As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.

AB - As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.

UR - http://www.scopus.com/inward/record.url?scp=84876477776&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876477776&partnerID=8YFLogxK

U2 - 10.1016/j.bbrc.2013.02.082

DO - 10.1016/j.bbrc.2013.02.082

M3 - Article

C2 - 23454382

AN - SCOPUS:84876477776

VL - 433

SP - 396

EP - 400

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 4

ER -

Functional inhibition of UQCRB suppresses angiogenesis in zebrafish

Abstract

Bibliographical note

All Science Journal Classification (ASJC) codes

Access to Document

Other files and links

Cite this