Functional inhibition of UQCRB suppresses angiogenesis in zebrafish

Yoon Sun Cho, Hye Jin Jung, Seung Hyeok Seok, Alexander Y. Payumo, James K. Chen, Ho Jeong Kwon

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.

Original languageEnglish
Pages (from-to)396-400
Number of pages5
JournalBiochemical and Biophysical Research Communications
Volume433
Issue number4
DOIs
Publication statusPublished - 2013 Apr 19

Fingerprint

Electron Transport Complex III
Zebrafish
Vascular Endothelial Growth Factor A
Mitochondria
Oxygen
Molecules
Pharmacology
Electron Transport
terpestacin

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

Cho, Yoon Sun ; Jung, Hye Jin ; Seok, Seung Hyeok ; Payumo, Alexander Y. ; Chen, James K. ; Kwon, Ho Jeong. / Functional inhibition of UQCRB suppresses angiogenesis in zebrafish. In: Biochemical and Biophysical Research Communications. 2013 ; Vol. 433, No. 4. pp. 396-400.
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Functional inhibition of UQCRB suppresses angiogenesis in zebrafish. / Cho, Yoon Sun; Jung, Hye Jin; Seok, Seung Hyeok; Payumo, Alexander Y.; Chen, James K.; Kwon, Ho Jeong.

In: Biochemical and Biophysical Research Communications, Vol. 433, No. 4, 19.04.2013, p. 396-400.

Research output: Contribution to journalArticle

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