Abstract
As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.
| Original language | English |
|---|---|
| Pages (from-to) | 396-400 |
| Number of pages | 5 |
| Journal | Biochemical and Biophysical Research Communications |
| Volume | 433 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 2013 Apr 19 |
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All Science Journal Classification (ASJC) codes
- Biophysics
- Biochemistry
- Molecular Biology
- Cell Biology
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Functional inhibition of UQCRB suppresses angiogenesis in zebrafish. / Cho, Yoon Sun; Jung, Hye Jin; Seok, Seung Hyeok; Payumo, Alexander Y.; Chen, James K.; Kwon, Ho Jeong.
In: Biochemical and Biophysical Research Communications, Vol. 433, No. 4, 19.04.2013, p. 396-400.Research output: Contribution to journal › Article
TY - JOUR
T1 - Functional inhibition of UQCRB suppresses angiogenesis in zebrafish
AU - Cho, Yoon Sun
AU - Jung, Hye Jin
AU - Seok, Seung Hyeok
AU - Payumo, Alexander Y.
AU - Chen, James K.
AU - Kwon, Ho Jeong
PY - 2013/4/19
Y1 - 2013/4/19
N2 - As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.
AB - As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.
UR - http://www.scopus.com/inward/record.url?scp=84876477776&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876477776&partnerID=8YFLogxK
U2 - 10.1016/j.bbrc.2013.02.082
DO - 10.1016/j.bbrc.2013.02.082
M3 - Article
VL - 433
SP - 396
EP - 400
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 4
ER -