As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.
|Number of pages||5|
|Journal||Biochemical and Biophysical Research Communications|
|Publication status||Published - 2013 Apr 19|
Bibliographical noteFunding Information:
This study was partly supported by Grants from the National Research Foundation (NRF) of Korea , the Korean Government ( MEST ; 2009-0092964 , 2010-0017984 , 2012M3A9D1054520 ), the Translational Research Center for Protein Function Control and the National Junior Research Fellowship , NRF ( 2009-0083522 , 2011-006165 ), the Center for Food and Drug Materials of Agriculture Science & Technology Development ( PJ0079772012 ), the Rural Development Administration , and the Brain Korea 21 Project, and the National Institutes of Health ( DP1 HD075622 to J.K.C.).
All Science Journal Classification (ASJC) codes
- Molecular Biology
- Cell Biology