Functional inhibition of UQCRB suppresses angiogenesis in zebrafish

Yoon Sun Cho; Hye Jin Jung; Seung Hyeok Seok; Alexander Y. Payumo; James K. Chen; Ho Jeong Kwon

doi:10.1016/j.bbrc.2013.02.082

Functional inhibition of UQCRB suppresses angiogenesis in zebrafish

Yoon Sun Cho, Hye Jin Jung, Seung Hyeok Seok, Alexander Y. Payumo, James K. Chen, Ho Jeong Kwon

Research output: Contribution to journal › Article

18 Citations (Scopus)

Abstract

As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.

Original language	English
Pages (from-to)	396-400
Number of pages	5
Journal	Biochemical and Biophysical Research Communications
Volume	433
Issue number	4
DOIs	https://doi.org/10.1016/j.bbrc.2013.02.082
Publication status	Published - 2013 Apr 19

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All Science Journal Classification (ASJC) codes

Biophysics
Biochemistry
Molecular Biology
Cell Biology

Cite this

Cho, Y. S., Jung, H. J., Seok, S. H., Payumo, A. Y., Chen, J. K., & Kwon, H. J. (2013). Functional inhibition of UQCRB suppresses angiogenesis in zebrafish. Biochemical and Biophysical Research Communications, 433(4), 396-400. https://doi.org/10.1016/j.bbrc.2013.02.082

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abstract = "As a subunit of mitochondrial complex III, UQCRB plays an important role in complex III stability, electron transport, and cellular oxygen sensing. Herein, we report UQCRB function regarding angiogenesis in vivo with the zebrafish (Danio rerio). UQCRB knockdown inhibited angiogenesis in zebrafish leading to the suppression of VEGF expression. Moreover, the UQCRB-targeting small molecule terpestacin also inhibited angiogenesis and VEGF levels in zebrafish, supporting the role of UQCRB in angiogenesis. Collectively, UQCRB loss of function by either genetic and pharmacological means inhibited angiogenesis, indicating that UQCRB plays a key role in this process and can be a prognostic marker of angiogenesis- and mitochondria-related diseases.",

author = "Cho, {Yoon Sun} and Jung, {Hye Jin} and Seok, {Seung Hyeok} and Payumo, {Alexander Y.} and Chen, {James K.} and Kwon, {Ho Jeong}",

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AU - Chen, James K.

AU - Kwon, Ho Jeong

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10.1016/j.bbrc.2013.02.082