Functional nanoplatforms for enhancement of chemotherapeutic index

Jaemoon Yang, Eugene Lee, Minhee Ku, Yong Min Huh, Jae Ho Cheong

Research output: Contribution to journalReview article

2 Citations (Scopus)

Abstract

Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.

Original languageEnglish
Pages (from-to)212-221
Number of pages10
JournalAnti-Cancer Agents in Medicinal Chemistry
Volume13
Issue number2
DOIs
Publication statusPublished - 2013 Apr 30

Fingerprint

Nanoparticles
Neoplasms
Drug Carriers
Therapeutics
Nanotechnology
Combination Drug Therapy
Neoplasm Metastasis
Recurrence

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Pharmacology
  • Cancer Research

Cite this

Yang, Jaemoon ; Lee, Eugene ; Ku, Minhee ; Huh, Yong Min ; Cheong, Jae Ho. / Functional nanoplatforms for enhancement of chemotherapeutic index. In: Anti-Cancer Agents in Medicinal Chemistry. 2013 ; Vol. 13, No. 2. pp. 212-221.
@article{d3eba328e8e143d6a96f6b923cb4268e,
title = "Functional nanoplatforms for enhancement of chemotherapeutic index",
abstract = "Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.",
author = "Jaemoon Yang and Eugene Lee and Minhee Ku and Huh, {Yong Min} and Cheong, {Jae Ho}",
year = "2013",
month = "4",
day = "30",
doi = "10.2174/1871520611313020005",
language = "English",
volume = "13",
pages = "212--221",
journal = "Anti-Cancer Agents in Medicinal Chemistry",
issn = "1871-5206",
publisher = "Bentham Science Publishers B.V.",
number = "2",

}

Functional nanoplatforms for enhancement of chemotherapeutic index. / Yang, Jaemoon; Lee, Eugene; Ku, Minhee; Huh, Yong Min; Cheong, Jae Ho.

In: Anti-Cancer Agents in Medicinal Chemistry, Vol. 13, No. 2, 30.04.2013, p. 212-221.

Research output: Contribution to journalReview article

TY - JOUR

T1 - Functional nanoplatforms for enhancement of chemotherapeutic index

AU - Yang, Jaemoon

AU - Lee, Eugene

AU - Ku, Minhee

AU - Huh, Yong Min

AU - Cheong, Jae Ho

PY - 2013/4/30

Y1 - 2013/4/30

N2 - Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.

AB - Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.

UR - http://www.scopus.com/inward/record.url?scp=84876701193&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84876701193&partnerID=8YFLogxK

U2 - 10.2174/1871520611313020005

DO - 10.2174/1871520611313020005

M3 - Review article

C2 - 22934694

AN - SCOPUS:84876701193

VL - 13

SP - 212

EP - 221

JO - Anti-Cancer Agents in Medicinal Chemistry

JF - Anti-Cancer Agents in Medicinal Chemistry

SN - 1871-5206

IS - 2

ER -