Abstract
Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.
| Original language | English |
|---|---|
| Pages (from-to) | 212-221 |
| Number of pages | 10 |
| Journal | Anti-Cancer Agents in Medicinal Chemistry |
| Volume | 13 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 2013 Apr 30 |
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All Science Journal Classification (ASJC) codes
- Molecular Medicine
- Pharmacology
- Cancer Research
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Functional nanoplatforms for enhancement of chemotherapeutic index. / Yang, Jaemoon; Lee, Eugene; Ku, Minhee; Huh, Yong Min; Cheong, Jae Ho.
In: Anti-Cancer Agents in Medicinal Chemistry, Vol. 13, No. 2, 30.04.2013, p. 212-221.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Functional nanoplatforms for enhancement of chemotherapeutic index
AU - Yang, Jaemoon
AU - Lee, Eugene
AU - Ku, Minhee
AU - Huh, Yong Min
AU - Cheong, Jae Ho
PY - 2013/4/30
Y1 - 2013/4/30
N2 - Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.
AB - Recently, the advancement of nanotechnology has had a significant impact on clinical therapeutics. Advances in biocompatible drug carriers using organic/inorganic nanoparticles have enabled safer and more efficient delivery of anti-cancer agents. In particular, nanoparticles designed and fabricated by sophisticated processes can (as drug carriers) deliver precise doses of multiple anti-cancer agents to target cancer cells, improving therapeutic efficacy and minimizing side effects. In addition, a comprehensive understanding of cancer biology, chemo-resistance, cancer relapse, and metastasis is essential for successful development of combination therapy using nanoparticles. In this review, we discuss the species of functional nanoparticles for delivery of anti-cancer agents and their potential to improve chemotherapeutic indices via combination therapy. We also discuss novel therapeutic strategies using functional nanoparticles developed through multidisciplinary collaboration for combination chemotherapy.
UR - http://www.scopus.com/inward/record.url?scp=84876701193&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84876701193&partnerID=8YFLogxK
U2 - 10.2174/1871520611313020005
DO - 10.2174/1871520611313020005
M3 - Review article
C2 - 22934694
AN - SCOPUS:84876701193
VL - 13
SP - 212
EP - 221
JO - Anti-Cancer Agents in Medicinal Chemistry
JF - Anti-Cancer Agents in Medicinal Chemistry
SN - 1871-5206
IS - 2
ER -