Functional polymorphism in manganese superoxide dismutase and antioxidant status

Their interactions on the risk of cervical intraepithelial neoplasia and cervical cancer

Seo Yun Tong, Jong Min Lee, Eun Seop Song, Kwang Beom Lee, Mi Kyung Kim, Jae Kwan Lee, Sung Kyong Son, Jung Pil Lee, Jae-Hoon Kim, Yong Il Kwon

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Objective: Manganese superoxide dismutase (MnSOD), the primary antioxidant enzyme in mitochondria, plays a key role in protecting cells from oxidative stress. Furthermore, the MnSOD rs4880 polymorphism is associated with enzyme activity. The authors evaluated the interaction between MnSOD genotypes and cervical carcinogenesis risk and the modulating effects of serum antioxidant nutrient status (β-carotene, lycopene, zeaxanthin/lutein, retinol, α-tocopherol and γ-tocopherol). Methods: Cases and controls for this study were recruited between June 2006 and July 2007 (263 controls, 84 cervical intraepithelial neoplasia (CIN), 94 CIN 2/3, and 99 cases of cervical cancer). The MnSOD polymorphism at rs4880T/C was examined using SNaPshot assays. Serum antioxidant vitamin concentrations were measured by reverse-phase gradient high-pressure liquid chromatography. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated after adjusting for age, menopause, parity, oral contraceptive use, smoking and alcohol consumption. Results: No association was found between the MnSOD rs4880 polymorphism and cervical cancer. However, genotypes significantly modified the risk of cervical cancer in association with the serum statuses of micronutrients (Pinteraction < 0.05 for β-carotene, lycopene, zeaxanthin/lutein, α-tocopherol, and γ-tocopherol). Decreased CIN1 risk in association with the MnSOD rs4880 variant genotype was also observed particularly for subjects with higher β-carotene and γ-tocopherol levels. Similar results were observed for lycopene and α-tocopherol in relation to the risk of CIN2/3. Conclusion: Our findings suggest that a higher antioxidant micronutrients status may decrease the risk of CIN and cervical cancer and modify the effect of the MnSOD polymorphism on disease risk.

Original languageEnglish
Pages (from-to)272-276
Number of pages5
JournalGynecologic Oncology
Volume115
Issue number2
DOIs
Publication statusPublished - 2009 Nov 1

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Cervical Intraepithelial Neoplasia
Tocopherols
Uterine Cervical Neoplasms
Superoxide Dismutase
Antioxidants
Carotenoids
Lutein
Micronutrients
Genotype
Serum
Enzymes
Oral Contraceptives
Menopause
Parity
Vitamin A
Vitamins
Alcohol Drinking
Case-Control Studies
Mitochondria
Carcinogenesis

All Science Journal Classification (ASJC) codes

  • Oncology
  • Obstetrics and Gynaecology

Cite this

Tong, Seo Yun ; Lee, Jong Min ; Song, Eun Seop ; Lee, Kwang Beom ; Kim, Mi Kyung ; Lee, Jae Kwan ; Son, Sung Kyong ; Lee, Jung Pil ; Kim, Jae-Hoon ; Kwon, Yong Il. / Functional polymorphism in manganese superoxide dismutase and antioxidant status : Their interactions on the risk of cervical intraepithelial neoplasia and cervical cancer. In: Gynecologic Oncology. 2009 ; Vol. 115, No. 2. pp. 272-276.
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title = "Functional polymorphism in manganese superoxide dismutase and antioxidant status: Their interactions on the risk of cervical intraepithelial neoplasia and cervical cancer",
abstract = "Objective: Manganese superoxide dismutase (MnSOD), the primary antioxidant enzyme in mitochondria, plays a key role in protecting cells from oxidative stress. Furthermore, the MnSOD rs4880 polymorphism is associated with enzyme activity. The authors evaluated the interaction between MnSOD genotypes and cervical carcinogenesis risk and the modulating effects of serum antioxidant nutrient status (β-carotene, lycopene, zeaxanthin/lutein, retinol, α-tocopherol and γ-tocopherol). Methods: Cases and controls for this study were recruited between June 2006 and July 2007 (263 controls, 84 cervical intraepithelial neoplasia (CIN), 94 CIN 2/3, and 99 cases of cervical cancer). The MnSOD polymorphism at rs4880T/C was examined using SNaPshot assays. Serum antioxidant vitamin concentrations were measured by reverse-phase gradient high-pressure liquid chromatography. Odds ratios (OR) and 95{\%} confidence intervals (95{\%}CI) were estimated after adjusting for age, menopause, parity, oral contraceptive use, smoking and alcohol consumption. Results: No association was found between the MnSOD rs4880 polymorphism and cervical cancer. However, genotypes significantly modified the risk of cervical cancer in association with the serum statuses of micronutrients (Pinteraction < 0.05 for β-carotene, lycopene, zeaxanthin/lutein, α-tocopherol, and γ-tocopherol). Decreased CIN1 risk in association with the MnSOD rs4880 variant genotype was also observed particularly for subjects with higher β-carotene and γ-tocopherol levels. Similar results were observed for lycopene and α-tocopherol in relation to the risk of CIN2/3. Conclusion: Our findings suggest that a higher antioxidant micronutrients status may decrease the risk of CIN and cervical cancer and modify the effect of the MnSOD polymorphism on disease risk.",
author = "Tong, {Seo Yun} and Lee, {Jong Min} and Song, {Eun Seop} and Lee, {Kwang Beom} and Kim, {Mi Kyung} and Lee, {Jae Kwan} and Son, {Sung Kyong} and Lee, {Jung Pil} and Jae-Hoon Kim and Kwon, {Yong Il}",
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Functional polymorphism in manganese superoxide dismutase and antioxidant status : Their interactions on the risk of cervical intraepithelial neoplasia and cervical cancer. / Tong, Seo Yun; Lee, Jong Min; Song, Eun Seop; Lee, Kwang Beom; Kim, Mi Kyung; Lee, Jae Kwan; Son, Sung Kyong; Lee, Jung Pil; Kim, Jae-Hoon; Kwon, Yong Il.

In: Gynecologic Oncology, Vol. 115, No. 2, 01.11.2009, p. 272-276.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Functional polymorphism in manganese superoxide dismutase and antioxidant status

T2 - Their interactions on the risk of cervical intraepithelial neoplasia and cervical cancer

AU - Tong, Seo Yun

AU - Lee, Jong Min

AU - Song, Eun Seop

AU - Lee, Kwang Beom

AU - Kim, Mi Kyung

AU - Lee, Jae Kwan

AU - Son, Sung Kyong

AU - Lee, Jung Pil

AU - Kim, Jae-Hoon

AU - Kwon, Yong Il

PY - 2009/11/1

Y1 - 2009/11/1

N2 - Objective: Manganese superoxide dismutase (MnSOD), the primary antioxidant enzyme in mitochondria, plays a key role in protecting cells from oxidative stress. Furthermore, the MnSOD rs4880 polymorphism is associated with enzyme activity. The authors evaluated the interaction between MnSOD genotypes and cervical carcinogenesis risk and the modulating effects of serum antioxidant nutrient status (β-carotene, lycopene, zeaxanthin/lutein, retinol, α-tocopherol and γ-tocopherol). Methods: Cases and controls for this study were recruited between June 2006 and July 2007 (263 controls, 84 cervical intraepithelial neoplasia (CIN), 94 CIN 2/3, and 99 cases of cervical cancer). The MnSOD polymorphism at rs4880T/C was examined using SNaPshot assays. Serum antioxidant vitamin concentrations were measured by reverse-phase gradient high-pressure liquid chromatography. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated after adjusting for age, menopause, parity, oral contraceptive use, smoking and alcohol consumption. Results: No association was found between the MnSOD rs4880 polymorphism and cervical cancer. However, genotypes significantly modified the risk of cervical cancer in association with the serum statuses of micronutrients (Pinteraction < 0.05 for β-carotene, lycopene, zeaxanthin/lutein, α-tocopherol, and γ-tocopherol). Decreased CIN1 risk in association with the MnSOD rs4880 variant genotype was also observed particularly for subjects with higher β-carotene and γ-tocopherol levels. Similar results were observed for lycopene and α-tocopherol in relation to the risk of CIN2/3. Conclusion: Our findings suggest that a higher antioxidant micronutrients status may decrease the risk of CIN and cervical cancer and modify the effect of the MnSOD polymorphism on disease risk.

AB - Objective: Manganese superoxide dismutase (MnSOD), the primary antioxidant enzyme in mitochondria, plays a key role in protecting cells from oxidative stress. Furthermore, the MnSOD rs4880 polymorphism is associated with enzyme activity. The authors evaluated the interaction between MnSOD genotypes and cervical carcinogenesis risk and the modulating effects of serum antioxidant nutrient status (β-carotene, lycopene, zeaxanthin/lutein, retinol, α-tocopherol and γ-tocopherol). Methods: Cases and controls for this study were recruited between June 2006 and July 2007 (263 controls, 84 cervical intraepithelial neoplasia (CIN), 94 CIN 2/3, and 99 cases of cervical cancer). The MnSOD polymorphism at rs4880T/C was examined using SNaPshot assays. Serum antioxidant vitamin concentrations were measured by reverse-phase gradient high-pressure liquid chromatography. Odds ratios (OR) and 95% confidence intervals (95%CI) were estimated after adjusting for age, menopause, parity, oral contraceptive use, smoking and alcohol consumption. Results: No association was found between the MnSOD rs4880 polymorphism and cervical cancer. However, genotypes significantly modified the risk of cervical cancer in association with the serum statuses of micronutrients (Pinteraction < 0.05 for β-carotene, lycopene, zeaxanthin/lutein, α-tocopherol, and γ-tocopherol). Decreased CIN1 risk in association with the MnSOD rs4880 variant genotype was also observed particularly for subjects with higher β-carotene and γ-tocopherol levels. Similar results were observed for lycopene and α-tocopherol in relation to the risk of CIN2/3. Conclusion: Our findings suggest that a higher antioxidant micronutrients status may decrease the risk of CIN and cervical cancer and modify the effect of the MnSOD polymorphism on disease risk.

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