This study reports polysaccharide-based fibers that can be utilized as biocompatible functional sutures. Fibers are spontaneously formed by spinning at the interface between two oppositely charged polysaccharide solutions. Unlike the common belief that polysaccharide fibers prepared by electrostatic interactions would exhibit weak mechanical strength, it is demonstrated that fibers spun at the interface between two droplets of positively charged chitosan and negatively charged heparin can exhibit high mechanical strength through spontaneous wet-state fusion of interfiber strands at a spinning wheel. Dry solidification results in multistranded fibers that were ≈100 µm in diameter with a tensile strength of ≈220 MPa. Post fibrous manipulation yields various morphology with straight or twisted fibers, fabrics, or springs. To demonstrate application of the fiber, it is applied as a medical suture. As heparin has a unique ability to bind adeno-associated virus (AAV), a therapeutic, biocompatible suture exhibiting localized AAV-mediated gene delivery function can be prepared. This study shows that multistrand fusion of fibers, formed by weak, electrostatic interactions and followed by drying solidification counterintuitively results in mechanically strong, functional fibers with various potential applications.
Bibliographical noteFunding Information:
M.D. and B.G.I. contributed equally to this work. This work was supported by a grant from the National R&D Program for Cancer Control, Ministry for Health and Welfare, Republic of Korea (1631060 (H.L.)). In addition, this research was supported by the National Research Foundation of Republic of Korea (NRF) Grant funded by the Korea government (MSIP) (NRF-2015R1A2A2A03003553) and the Ministry of Science, ICT & Future Planning for convergent research: Development program for convergence R&D over traditional culture and current technology (NRF-2016M3C1B5906485 (H.L.)), and Disaster and safety Management Institute (MPSS-MC-2016-02 (H.L.)) from The Ministry of Public Safety and Security of Republic of Korea.
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All Science Journal Classification (ASJC) codes
- Materials Science(all)
- Condensed Matter Physics