Functional Polysaccharide Sutures Prepared by Wet Fusion of Interfacial Polyelectrolyte Complexation Fibers

Minjae Do, Byung Gee Im, Joseph P. Park, Jae-Hyung Jang, Haeshin Lee

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

This study reports polysaccharide-based fibers that can be utilized as biocompatible functional sutures. Fibers are spontaneously formed by spinning at the interface between two oppositely charged polysaccharide solutions. Unlike the common belief that polysaccharide fibers prepared by electrostatic interactions would exhibit weak mechanical strength, it is demonstrated that fibers spun at the interface between two droplets of positively charged chitosan and negatively charged heparin can exhibit high mechanical strength through spontaneous wet-state fusion of interfiber strands at a spinning wheel. Dry solidification results in multistranded fibers that were ≈100 µm in diameter with a tensile strength of ≈220 MPa. Post fibrous manipulation yields various morphology with straight or twisted fibers, fabrics, or springs. To demonstrate application of the fiber, it is applied as a medical suture. As heparin has a unique ability to bind adeno-associated virus (AAV), a therapeutic, biocompatible suture exhibiting localized AAV-mediated gene delivery function can be prepared. This study shows that multistrand fusion of fibers, formed by weak, electrostatic interactions and followed by drying solidification counterintuitively results in mechanically strong, functional fibers with various potential applications.

Original languageEnglish
Article number1702017
JournalAdvanced Functional Materials
Volume27
Issue number42
DOIs
Publication statusPublished - 2017 Nov 10

Fingerprint

polysaccharides
Polysaccharides
Polyelectrolytes
Complexation
Fusion reactions
fusion
fibers
Fibers
heparins
viruses
Coulomb interactions
Viruses
metal spinning
solidification
Strength of materials
Solidification
Heparin
electrostatics
Chitosan
wheels

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

Cite this

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title = "Functional Polysaccharide Sutures Prepared by Wet Fusion of Interfacial Polyelectrolyte Complexation Fibers",
abstract = "This study reports polysaccharide-based fibers that can be utilized as biocompatible functional sutures. Fibers are spontaneously formed by spinning at the interface between two oppositely charged polysaccharide solutions. Unlike the common belief that polysaccharide fibers prepared by electrostatic interactions would exhibit weak mechanical strength, it is demonstrated that fibers spun at the interface between two droplets of positively charged chitosan and negatively charged heparin can exhibit high mechanical strength through spontaneous wet-state fusion of interfiber strands at a spinning wheel. Dry solidification results in multistranded fibers that were ≈100 µm in diameter with a tensile strength of ≈220 MPa. Post fibrous manipulation yields various morphology with straight or twisted fibers, fabrics, or springs. To demonstrate application of the fiber, it is applied as a medical suture. As heparin has a unique ability to bind adeno-associated virus (AAV), a therapeutic, biocompatible suture exhibiting localized AAV-mediated gene delivery function can be prepared. This study shows that multistrand fusion of fibers, formed by weak, electrostatic interactions and followed by drying solidification counterintuitively results in mechanically strong, functional fibers with various potential applications.",
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Functional Polysaccharide Sutures Prepared by Wet Fusion of Interfacial Polyelectrolyte Complexation Fibers. / Do, Minjae; Im, Byung Gee; Park, Joseph P.; Jang, Jae-Hyung; Lee, Haeshin.

In: Advanced Functional Materials, Vol. 27, No. 42, 1702017, 10.11.2017.

Research output: Contribution to journalArticle

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