Functional Roles of O-Glcnac in Cell Signaling

Sujin Park, Jin Won Cho

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Many nuclear and cytosolic proteins are modified with O-linked β-N-acetylglucosamine (O-GlcNAc) at serine or threonine residues. This O-GlcNAcylation is a dynamic posttranslational modification similar to phosphorylation. In addition, O-GlcNAcylation and phosphorylation have a reciprocal relationship to modulate the function of proteins. There are three types of dynamic interplay between O-GlcNAcylation and phosphorylation. These two modifications occur on same site of the protein or occur on two different sites nearby. Therefore, there is a competitive relationship between O-GlcNAcylation and phosphorylation. The third possibility is these two modifications occur on multiple sites of proteins, and they affect each other or not. In this case, the modification status is changed by cellular signaling. O-GlcNAc modification has vital roles in protein localization, protein degradation, protein stability, transcription, translation, cell cycle regulation, protein-protein interaction, epigenetic regulation, and various diseases including cancer, diabetes, and neurodegenerative diseases. This chapter presents an overview of the function of O-GlcNAc modification in various signaling pathways.

Original languageEnglish
Title of host publicationGlycoscience
Subtitle of host publicationBiology and Medicine
PublisherSpringer Japan
Pages1213-1220
Number of pages8
ISBN (Electronic)9784431548416
ISBN (Print)9784431548409
DOIs
Publication statusPublished - 2015 Jan 1

Fingerprint

Cell signaling
Phosphorylation
Proteins
Cell Cycle Proteins
Acetylglucosamine
Protein Stability
Threonine
Post Translational Protein Processing
Nuclear Proteins
Epigenomics
Neurodegenerative Diseases
Serine
Proteolysis
Neurodegenerative diseases
Transcription
Medical problems
Neoplasms
Cells
Degradation

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Medicine(all)

Cite this

Park, S., & Cho, J. W. (2015). Functional Roles of O-Glcnac in Cell Signaling. In Glycoscience: Biology and Medicine (pp. 1213-1220). Springer Japan. https://doi.org/10.1007/978-4-431-54841-6_85
Park, Sujin ; Cho, Jin Won. / Functional Roles of O-Glcnac in Cell Signaling. Glycoscience: Biology and Medicine. Springer Japan, 2015. pp. 1213-1220
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Park, S & Cho, JW 2015, Functional Roles of O-Glcnac in Cell Signaling. in Glycoscience: Biology and Medicine. Springer Japan, pp. 1213-1220. https://doi.org/10.1007/978-4-431-54841-6_85

Functional Roles of O-Glcnac in Cell Signaling. / Park, Sujin; Cho, Jin Won.

Glycoscience: Biology and Medicine. Springer Japan, 2015. p. 1213-1220.

Research output: Chapter in Book/Report/Conference proceedingChapter

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Park S, Cho JW. Functional Roles of O-Glcnac in Cell Signaling. In Glycoscience: Biology and Medicine. Springer Japan. 2015. p. 1213-1220 https://doi.org/10.1007/978-4-431-54841-6_85