Techniques for the delivery foreign materials into living cells as well as for sensing have undeniable worth in cell biology research. A major barrier for intracellular delivery is to cross the cell membrane with little or no damage. Among the various intracellular delivery methods, one-dimensional nanoneedles are one of the promising methods for insertion with minimal invasiveness to a cell. Most of the previous studies have been conducted using vertical nanoneedle. Here, we synthesized new inclined nanoneedles and demonstrated a novel platform using inclined-gallium nitride nanoneedles (iGaN NNs) to facilitate efficient intracellular delivery. In our system, foreign molecules were successfully delivered into cytoplasm of a cell through the penetration of the cell membrane by the iGaN NNs.
Bibliographical noteFunding Information:
This research was financially supported by Ministry of Science, ICT, and Future Planning (Project No. NRF-2014M3A9E4064580), Advanced Biomass R&D Center (ABC) of the Global Frontier Project funded by the Ministry of Science, ICT, and Future Planning (NRF-2015M3A6A2074238), the Center for Advanced Meta-Materials (CAMM) funded by the Ministry of Science, ICT and Future Planning as Global Frontier Project ( CAMM-2014M3A6B3063716 ), and KAIST-Kustar Institute . This work was also supported by Mid-career Researcher Program through NRF grant funded by the MEST (2016R1A2B4010487).
© 2017 The Korean Society of Industrial and Engineering Chemistry
All Science Journal Classification (ASJC) codes
- Chemical Engineering(all)