At 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p = 0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p = 0.018). A higher IC50 was found in GG than GT/A genotype (p = 0.02) and in G-C than G-T haplotype (p = 0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p = 0.01) due to different polymorphism frequencies. We identified 65 genes that were differently expressed in cell lines of the G-C and G-T ABCB1 haplotypes. Ethnic differences in the G-T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity, and future clinical validation is necessary to confirm our findings. Crown
Bibliographical noteFunding Information:
This study was supported by a Grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare, Republic of Korea (0405-BC01-0604-0002).
All Science Journal Classification (ASJC) codes
- Cancer Research