G-T haplotype (2677G > T/A and 3435C > T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern

Woo Sun Kwon, SunYoung Rha, Hei Cheul Jeung, Joong Bae Ahn, Jae Joon Jung, Sung Hoon Noh, Hyuncheol Chung

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

At 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p = 0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p = 0.018). A higher IC 50 was found in GG than GT/A genotype (p = 0.02) and in G-C than G-T haplotype (p = 0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p = 0.01) due to different polymorphism frequencies. We identified 65 genes that were differently expressed in cell lines of the G-C and G-T ABCB1 haplotypes. Ethnic differences in the G-T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity, and future clinical validation is necessary to confirm our findings. Crown

Original languageEnglish
Pages (from-to)155-163
Number of pages9
JournalCancer Letters
Volume277
Issue number2
DOIs
Publication statusPublished - 2009 May 18

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Paclitaxel
Haplotypes
Gene Expression
Cell Line
Genes
Neoplasms
Crowns
Biomarkers
Genotype

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

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title = "G-T haplotype (2677G > T/A and 3435C > T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern",
abstract = "At 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p = 0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p = 0.018). A higher IC 50 was found in GG than GT/A genotype (p = 0.02) and in G-C than G-T haplotype (p = 0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p = 0.01) due to different polymorphism frequencies. We identified 65 genes that were differently expressed in cell lines of the G-C and G-T ABCB1 haplotypes. Ethnic differences in the G-T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity, and future clinical validation is necessary to confirm our findings. Crown",
author = "Kwon, {Woo Sun} and SunYoung Rha and Jeung, {Hei Cheul} and Ahn, {Joong Bae} and Jung, {Jae Joon} and Noh, {Sung Hoon} and Hyuncheol Chung",
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G-T haplotype (2677G > T/A and 3435C > T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern. / Kwon, Woo Sun; Rha, SunYoung; Jeung, Hei Cheul; Ahn, Joong Bae; Jung, Jae Joon; Noh, Sung Hoon; Chung, Hyuncheol.

In: Cancer Letters, Vol. 277, No. 2, 18.05.2009, p. 155-163.

Research output: Contribution to journalArticle

TY - JOUR

T1 - G-T haplotype (2677G > T/A and 3435C > T) of ABCB1 gene polymorphisms is associated with ethnic differences to paclitaxel sensitivity in cancer cells with different gene expression pattern

AU - Kwon, Woo Sun

AU - Rha, SunYoung

AU - Jeung, Hei Cheul

AU - Ahn, Joong Bae

AU - Jung, Jae Joon

AU - Noh, Sung Hoon

AU - Chung, Hyuncheol

PY - 2009/5/18

Y1 - 2009/5/18

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AB - At 2677, the GG and TT were most frequent in Asian cell lines, whereas the GT and GG were most frequent in non-Asians (p = 0.032). At 3435, TT and CC was most common in Asians and non-Asians, respectively (p = 0.018). A higher IC 50 was found in GG than GT/A genotype (p = 0.02) and in G-C than G-T haplotype (p = 0.046). Non-Asian cell lines were more sensitive to paclitaxel than Asian cell lines (p = 0.01) due to different polymorphism frequencies. We identified 65 genes that were differently expressed in cell lines of the G-C and G-T ABCB1 haplotypes. Ethnic differences in the G-T haplotype of the ABCB1 gene may be a biomarker for paclitaxel sensitivity, and future clinical validation is necessary to confirm our findings. Crown

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