Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging

Eun Kyung Lim, Byunghoon Kang, Yuna Choi, Eunji Jang, Seungmin Han, Kwangyeol Lee, Jinsuck Suh, Seungjoo Haam, yongmin Huh

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

We developed Pyrene-Gadolinium (Py-Gd) nanoparticles as pH-sensitive magnetic resonance imaging (MRI) contrast agents capable of showing a high-Mr signal in cancer-specific environments, such as acidic conditions. Py-Gd nanoparticles were prepared by coating Py-Gd, which is a complex of gadolinium with pyrenyl molecules, with pyrenyl polyethyleneglycol PEG using a nano-emulsion method. These particles show better longitudinal relaxation time (T1) MR signals in acidic conditions than they do in neutral conditions. Furthermore, the particles exhibit biocompatibility and MR contrast effects in both in vitro and in vivo studies. From these results, we confirm that Py-Gd nanoparticles have the potential to be applied for accurate cancer diagnosis and therapy.

Original languageEnglish
Article number245103
JournalNanotechnology
Volume25
Issue number24
DOIs
Publication statusPublished - 2014 Jun 20

Fingerprint

Gadolinium
Magnetic resonance
Pyrene
Nanoparticles
Imaging techniques
Emulsions
Biocompatibility
Relaxation time
Contrast Media
Polyethylene glycols
Coatings
Molecules
pyrene

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

Lim, Eun Kyung ; Kang, Byunghoon ; Choi, Yuna ; Jang, Eunji ; Han, Seungmin ; Lee, Kwangyeol ; Suh, Jinsuck ; Haam, Seungjoo ; Huh, yongmin. / Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging. In: Nanotechnology. 2014 ; Vol. 25, No. 24.
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Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging. / Lim, Eun Kyung; Kang, Byunghoon; Choi, Yuna; Jang, Eunji; Han, Seungmin; Lee, Kwangyeol; Suh, Jinsuck; Haam, Seungjoo; Huh, yongmin.

In: Nanotechnology, Vol. 25, No. 24, 245103, 20.06.2014.

Research output: Contribution to journalArticle

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T1 - Gadolinium-based nanoparticles for highly efficient T1-weighted magnetic resonance imaging

AU - Lim, Eun Kyung

AU - Kang, Byunghoon

AU - Choi, Yuna

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AU - Han, Seungmin

AU - Lee, Kwangyeol

AU - Suh, Jinsuck

AU - Haam, Seungjoo

AU - Huh, yongmin

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