Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma

Correlation with histological characteristics

Jin Young Choi, Myeong Jin Kim, Young Nyun Park, Jeong Min Lee, Sun Kook Yoo, SunYoung Rha, Jae Yeon Seok

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

OBJECTIVE. The purpose of this study was to assess whether gadoxetate disodium-enhanced hepatobiliary phase MRI could predict the histologic factors of hepatocellular carcinomas (HCCs). MATERIALS AND METHODS. Fifty-three HCCs histopathologically proved by surgery in 51 patients were evaluated retrospectively. All patients underwent gadoxetate disodium-enhanced MRI before surgical resection. The differences in contrast enhancement ratio of the lesions and differences in contrast-to-noise ratio (CNR) among the histologic grades of HCC were compared by using the Kruskal-Wallis test. The Spearman method was used to determine the correlations among contrast enhancement ratio, CNR, cell density ratio, and positivity for anti-hepatocyte antibody, keratin 7, and keratin 19. RESULTS. Of 53 HCCs, 50 showed low signal intensity on hepatobiliary phase images, whereas three HCCs were hyperintense on hepatobiliary phase images compared with surrounding hepatic parenchyma. Although well-differentiated HCCs tended to show higher contrast enhancement, there was no statistical significance between contrast enhancement ratio of the tumors and histologic grade (p = 0.414). No significant difference was observed between CNR and histologic grade (p = 0.965). The contrast enhancement ratios of the tumors were significantly lower in the keratin 19-positive group than in the keratin 19-negative group (p = 0.015). There was no significant correlation among contrast enhancement ratio, anti-hepatocyte antibody positivity, cell density ratio, and keratin 7 positivity (p > 0.05). CONCLUSION. The contrast enhancement ratio and CNR of HCCs were not correlated with histologic grades. The contrast enhancement ratio was significantly lower in keratin 19-positive HCCs.

Original languageEnglish
Pages (from-to)399-405
Number of pages7
JournalAmerican Journal of Roentgenology
Volume197
Issue number2
DOIs
Publication statusPublished - 2011 Aug 1

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Hepatocellular Carcinoma
Keratin-19
Noise
Keratin-7
Anti-Idiotypic Antibodies
Hepatocytes
Cell Count
gadolinium ethoxybenzyl DTPA
Neoplasms
Liver

All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

Cite this

Choi, Jin Young ; Kim, Myeong Jin ; Park, Young Nyun ; Lee, Jeong Min ; Yoo, Sun Kook ; Rha, SunYoung ; Seok, Jae Yeon. / Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma : Correlation with histological characteristics. In: American Journal of Roentgenology. 2011 ; Vol. 197, No. 2. pp. 399-405.
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abstract = "OBJECTIVE. The purpose of this study was to assess whether gadoxetate disodium-enhanced hepatobiliary phase MRI could predict the histologic factors of hepatocellular carcinomas (HCCs). MATERIALS AND METHODS. Fifty-three HCCs histopathologically proved by surgery in 51 patients were evaluated retrospectively. All patients underwent gadoxetate disodium-enhanced MRI before surgical resection. The differences in contrast enhancement ratio of the lesions and differences in contrast-to-noise ratio (CNR) among the histologic grades of HCC were compared by using the Kruskal-Wallis test. The Spearman method was used to determine the correlations among contrast enhancement ratio, CNR, cell density ratio, and positivity for anti-hepatocyte antibody, keratin 7, and keratin 19. RESULTS. Of 53 HCCs, 50 showed low signal intensity on hepatobiliary phase images, whereas three HCCs were hyperintense on hepatobiliary phase images compared with surrounding hepatic parenchyma. Although well-differentiated HCCs tended to show higher contrast enhancement, there was no statistical significance between contrast enhancement ratio of the tumors and histologic grade (p = 0.414). No significant difference was observed between CNR and histologic grade (p = 0.965). The contrast enhancement ratios of the tumors were significantly lower in the keratin 19-positive group than in the keratin 19-negative group (p = 0.015). There was no significant correlation among contrast enhancement ratio, anti-hepatocyte antibody positivity, cell density ratio, and keratin 7 positivity (p > 0.05). CONCLUSION. The contrast enhancement ratio and CNR of HCCs were not correlated with histologic grades. The contrast enhancement ratio was significantly lower in keratin 19-positive HCCs.",
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Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma : Correlation with histological characteristics. / Choi, Jin Young; Kim, Myeong Jin; Park, Young Nyun; Lee, Jeong Min; Yoo, Sun Kook; Rha, SunYoung; Seok, Jae Yeon.

In: American Journal of Roentgenology, Vol. 197, No. 2, 01.08.2011, p. 399-405.

Research output: Contribution to journalArticle

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T1 - Gadoxetate disodium-enhanced hepatobiliary phase MRI of hepatocellular carcinoma

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AU - Choi, Jin Young

AU - Kim, Myeong Jin

AU - Park, Young Nyun

AU - Lee, Jeong Min

AU - Yoo, Sun Kook

AU - Rha, SunYoung

AU - Seok, Jae Yeon

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N2 - OBJECTIVE. The purpose of this study was to assess whether gadoxetate disodium-enhanced hepatobiliary phase MRI could predict the histologic factors of hepatocellular carcinomas (HCCs). MATERIALS AND METHODS. Fifty-three HCCs histopathologically proved by surgery in 51 patients were evaluated retrospectively. All patients underwent gadoxetate disodium-enhanced MRI before surgical resection. The differences in contrast enhancement ratio of the lesions and differences in contrast-to-noise ratio (CNR) among the histologic grades of HCC were compared by using the Kruskal-Wallis test. The Spearman method was used to determine the correlations among contrast enhancement ratio, CNR, cell density ratio, and positivity for anti-hepatocyte antibody, keratin 7, and keratin 19. RESULTS. Of 53 HCCs, 50 showed low signal intensity on hepatobiliary phase images, whereas three HCCs were hyperintense on hepatobiliary phase images compared with surrounding hepatic parenchyma. Although well-differentiated HCCs tended to show higher contrast enhancement, there was no statistical significance between contrast enhancement ratio of the tumors and histologic grade (p = 0.414). No significant difference was observed between CNR and histologic grade (p = 0.965). The contrast enhancement ratios of the tumors were significantly lower in the keratin 19-positive group than in the keratin 19-negative group (p = 0.015). There was no significant correlation among contrast enhancement ratio, anti-hepatocyte antibody positivity, cell density ratio, and keratin 7 positivity (p > 0.05). CONCLUSION. The contrast enhancement ratio and CNR of HCCs were not correlated with histologic grades. The contrast enhancement ratio was significantly lower in keratin 19-positive HCCs.

AB - OBJECTIVE. The purpose of this study was to assess whether gadoxetate disodium-enhanced hepatobiliary phase MRI could predict the histologic factors of hepatocellular carcinomas (HCCs). MATERIALS AND METHODS. Fifty-three HCCs histopathologically proved by surgery in 51 patients were evaluated retrospectively. All patients underwent gadoxetate disodium-enhanced MRI before surgical resection. The differences in contrast enhancement ratio of the lesions and differences in contrast-to-noise ratio (CNR) among the histologic grades of HCC were compared by using the Kruskal-Wallis test. The Spearman method was used to determine the correlations among contrast enhancement ratio, CNR, cell density ratio, and positivity for anti-hepatocyte antibody, keratin 7, and keratin 19. RESULTS. Of 53 HCCs, 50 showed low signal intensity on hepatobiliary phase images, whereas three HCCs were hyperintense on hepatobiliary phase images compared with surrounding hepatic parenchyma. Although well-differentiated HCCs tended to show higher contrast enhancement, there was no statistical significance between contrast enhancement ratio of the tumors and histologic grade (p = 0.414). No significant difference was observed between CNR and histologic grade (p = 0.965). The contrast enhancement ratios of the tumors were significantly lower in the keratin 19-positive group than in the keratin 19-negative group (p = 0.015). There was no significant correlation among contrast enhancement ratio, anti-hepatocyte antibody positivity, cell density ratio, and keratin 7 positivity (p > 0.05). CONCLUSION. The contrast enhancement ratio and CNR of HCCs were not correlated with histologic grades. The contrast enhancement ratio was significantly lower in keratin 19-positive HCCs.

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