Galactosylated magnetic nanovectors for regulation of lipid metabolism based on biomarker-specific RNAi and MR imaging

Dan Heo, Chanjoo Lee, Minhee Ku, Seungjoo Haam, Jinsuck Suh, yongmin Huh, Sahng Wook Park, Jaemoon Yang

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

The specific delivery of ribonucleic acid (RNA) interfering molecules to disease-related cells is still a critical blockade for in vivo systemic treatment. Here, this study suggests a robust delivery carrier for targeted delivery of RNA-interfering molecules using galactosylated magnetic nanovectors (gMNVs). gMNVs are an organic-inorganic polymeric nanomaterial composed of polycationics and magnetic nanocrystal for delivery of RNA-interfering molecules and tracking via magnetic resonance (MR) imaging. In particular, the surface of gMNVs was modified by galactosylgluconic groups for targeted delivering to asialoglycoprotein receptor (ASGPR) of hepatocytes. Moreover, the small interfering RNAs were used to regulate target proteins related with low-density lipoprotein level and in vivo MR imaging was conducted for tracking of nanovectors. The obtained results show that the prepared gMNVs demonstrate potential as a systemic theragnostic nanoplatform for RNA interference and MR imaging.

Original languageEnglish
Article number335101
JournalNanotechnology
Volume26
Issue number33
DOIs
Publication statusPublished - 2015 Aug 21

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Biomarkers
Magnetic resonance
RNA
Imaging techniques
Molecules
Asialoglycoprotein Receptor
Lipoproteins
LDL Lipoproteins
Nanostructured materials
Nanocrystals
Small Interfering RNA
Lipid Metabolism
Proteins

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering
  • Electrical and Electronic Engineering

Cite this

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abstract = "The specific delivery of ribonucleic acid (RNA) interfering molecules to disease-related cells is still a critical blockade for in vivo systemic treatment. Here, this study suggests a robust delivery carrier for targeted delivery of RNA-interfering molecules using galactosylated magnetic nanovectors (gMNVs). gMNVs are an organic-inorganic polymeric nanomaterial composed of polycationics and magnetic nanocrystal for delivery of RNA-interfering molecules and tracking via magnetic resonance (MR) imaging. In particular, the surface of gMNVs was modified by galactosylgluconic groups for targeted delivering to asialoglycoprotein receptor (ASGPR) of hepatocytes. Moreover, the small interfering RNAs were used to regulate target proteins related with low-density lipoprotein level and in vivo MR imaging was conducted for tracking of nanovectors. The obtained results show that the prepared gMNVs demonstrate potential as a systemic theragnostic nanoplatform for RNA interference and MR imaging.",
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Galactosylated magnetic nanovectors for regulation of lipid metabolism based on biomarker-specific RNAi and MR imaging. / Heo, Dan; Lee, Chanjoo; Ku, Minhee; Haam, Seungjoo; Suh, Jinsuck; Huh, yongmin; Park, Sahng Wook; Yang, Jaemoon.

In: Nanotechnology, Vol. 26, No. 33, 335101, 21.08.2015.

Research output: Contribution to journalArticle

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AU - Heo, Dan

AU - Lee, Chanjoo

AU - Ku, Minhee

AU - Haam, Seungjoo

AU - Suh, Jinsuck

AU - Huh, yongmin

AU - Park, Sahng Wook

AU - Yang, Jaemoon

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