Gallic Acid Promotes Wound Healing in Normal and Hyperglucidic Conditions

Dong Joo Yang, Sang Hyun Moh, Dong Hwee Son, Seunghoon You, Ann W. Kinyua, Chang Mann Ko, Miyoung Song, Jinhee Yeo, Yun Hee Choi, Ki Woo Kim

Research output: Contribution to journalArticle

35 Citations (Scopus)

Abstract

Skin is the outermost layer of the human body that is constantly exposed to environmental stressors, such as UV radiation and toxic chemicals, and is susceptible to mechanical wounding and injury. The ability of the skin to repair injuries is paramount for survival and it is disrupted in a spectrum of disorders leading to skin pathologies. Diabetic patients often suffer from chronic, impaired wound healing, which facilitate bacterial infections and necessitate amputation. Here, we studied the effects of gallic acid (GA, 3,4,5-trihydroxybenzoic acid; a plant-derived polyphenolic compound) on would healing in normal and hyperglucidic conditions, to mimic diabetes, in human keratinocytes and fibroblasts. Our study reveals that GA is a potential antioxidant that directly upregulates the expression of antioxidant genes. In addition, GA accelerated cell migration of keratinocytes and fibroblasts in both normal and hyperglucidic conditions. Further, GA treatment activated factors known to be hallmarks of wound healing, such as focal adhesion kinases (FAK), c-Jun N-terminal kinases (JNK), and extracellular signal-regulated kinases (Erk), underpinning the beneficial role of GA in wound repair. Therefore, our results demonstrate that GA might be a viable wound healing agent and a potential intervention to treat wounds resulting from metabolic complications.

Original languageEnglish
Article number899
JournalMolecules
Volume21
Issue number7
DOIs
Publication statusPublished - 2016 Jul

All Science Journal Classification (ASJC) codes

  • Analytical Chemistry
  • Chemistry (miscellaneous)
  • Molecular Medicine
  • Pharmaceutical Science
  • Drug Discovery
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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  • Cite this

    Yang, D. J., Moh, S. H., Son, D. H., You, S., Kinyua, A. W., Ko, C. M., Song, M., Yeo, J., Choi, Y. H., & Kim, K. W. (2016). Gallic Acid Promotes Wound Healing in Normal and Hyperglucidic Conditions. Molecules, 21(7), [899]. https://doi.org/10.3390/molecules21070899