Gastric retentive drug-delivery systems

Sung Joo Hwang, Haesun Park, Kinam Park

Research output: Contribution to journalArticle

284 Citations (Scopus)

Abstract

The development of a long-term oral controlled-release dosage form has been difficult mainly because of the transit of the dosage form through the gastrointestinal (GI) tract. Several approaches to extend gastric residence time have been tried. The most commonly used systems are (1) intragastric floating systems, (2) high-density systems, (3) mucoadhesive systems, (4) magnetic systems, (5) unfoldable, extendible, or swellable systems, and (6) superporous hydrogel systems. The concept of each approach is examined, and improvements that are needed for further development are discussed. Background materials in the GI physiology that are necessary for understanding the concept and usefulness of each approach are also provided.

Original languageEnglish
Pages (from-to)243-284
Number of pages42
JournalCritical Reviews in Therapeutic Drug Carrier Systems
Volume15
Issue number3
Publication statusPublished - 1998 Aug 18

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Gastrointestinal Agents
Dosage Forms
Drug Delivery Systems
Hydrogel
Gastrointestinal Tract
Stomach

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Pharmaceutical Science

Cite this

Hwang, Sung Joo ; Park, Haesun ; Park, Kinam. / Gastric retentive drug-delivery systems. In: Critical Reviews in Therapeutic Drug Carrier Systems. 1998 ; Vol. 15, No. 3. pp. 243-284.
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Gastric retentive drug-delivery systems. / Hwang, Sung Joo; Park, Haesun; Park, Kinam.

In: Critical Reviews in Therapeutic Drug Carrier Systems, Vol. 15, No. 3, 18.08.1998, p. 243-284.

Research output: Contribution to journalArticle

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