Gastrointestinal stromal tumors in Koreans: It's incidence and the clinical, pathologic and immunohistochemical findings

Kyoung Mee Kim, Wook Kang Dong, Sung Moon Woo, Bok Park Jae, Keun Park Cheol, Hee Sohn Jin, Sook Jeong Jin, Mee Yon Cho, So Young Jin, Sang Choi Jong, Dae Young Kang

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Abstract

Seven hundred forty seven cases of gastrointestinal stromal tumors (GISTs) in Koreans who were diagnosed between 2001 and 2002 were analyzed to evaluate their occurrence and their clinical, pathologic and immunohistochemical findings. The most frequent location of tumor was in the stomach (63%), followed by the small intestine (30%), the colorectum (5%), and the esophagus (2%). c-kit expression was found in 93.6% of the cases, while CD34, SMA and S-100 protein was positive in 80.1%, 28.2%, and 20.2%, respectively. c-kit positivity was high in the stomach (94.2%) and small intestine (94.6%), while it was relatively low in the colorectum (85.0%), and esophagus (81.2%). The positivity for CD34 was correlated with the higher risk of GISTs (p=0.04). Follow up of the patients showed that 58 primary GISTs patients died and 20 of these patients were recurrent or metastatic at the time of diagnosis. The pathologic diagnosis to predict the risk of aggressive behavior of GISTs was correlated with the numbers of tumor, clinical stage, epithelioid histologic type, cellularity, cellular atypia, necrosis, and mucosal invasion (p=0.00). GISTs with a poor prognosis were closely related to the clinical stage at presentation, the locations of the tumor, and the ages of the patients.

Original languageEnglish
Pages (from-to)977-984
Number of pages8
JournalJournal of Korean medical science
Volume20
Issue number6
DOIs
Publication statusPublished - 2005 Dec

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Gastrointestinal Stromal Tumors
Incidence
Esophagus
Small Intestine
Stomach
Neoplasms
S100 Proteins
Risk-Taking
Necrosis

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Kyoung Mee ; Dong, Wook Kang ; Woo, Sung Moon ; Jae, Bok Park ; Cheol, Keun Park ; Jin, Hee Sohn ; Jin, Sook Jeong ; Cho, Mee Yon ; Jin, So Young ; Jong, Sang Choi ; Kang, Dae Young. / Gastrointestinal stromal tumors in Koreans : It's incidence and the clinical, pathologic and immunohistochemical findings. In: Journal of Korean medical science. 2005 ; Vol. 20, No. 6. pp. 977-984.
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title = "Gastrointestinal stromal tumors in Koreans: It's incidence and the clinical, pathologic and immunohistochemical findings",
abstract = "Seven hundred forty seven cases of gastrointestinal stromal tumors (GISTs) in Koreans who were diagnosed between 2001 and 2002 were analyzed to evaluate their occurrence and their clinical, pathologic and immunohistochemical findings. The most frequent location of tumor was in the stomach (63{\%}), followed by the small intestine (30{\%}), the colorectum (5{\%}), and the esophagus (2{\%}). c-kit expression was found in 93.6{\%} of the cases, while CD34, SMA and S-100 protein was positive in 80.1{\%}, 28.2{\%}, and 20.2{\%}, respectively. c-kit positivity was high in the stomach (94.2{\%}) and small intestine (94.6{\%}), while it was relatively low in the colorectum (85.0{\%}), and esophagus (81.2{\%}). The positivity for CD34 was correlated with the higher risk of GISTs (p=0.04). Follow up of the patients showed that 58 primary GISTs patients died and 20 of these patients were recurrent or metastatic at the time of diagnosis. The pathologic diagnosis to predict the risk of aggressive behavior of GISTs was correlated with the numbers of tumor, clinical stage, epithelioid histologic type, cellularity, cellular atypia, necrosis, and mucosal invasion (p=0.00). GISTs with a poor prognosis were closely related to the clinical stage at presentation, the locations of the tumor, and the ages of the patients.",
author = "Kim, {Kyoung Mee} and Dong, {Wook Kang} and Woo, {Sung Moon} and Jae, {Bok Park} and Cheol, {Keun Park} and Jin, {Hee Sohn} and Jin, {Sook Jeong} and Cho, {Mee Yon} and Jin, {So Young} and Jong, {Sang Choi} and Kang, {Dae Young}",
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Kim, KM, Dong, WK, Woo, SM, Jae, BP, Cheol, KP, Jin, HS, Jin, SJ, Cho, MY, Jin, SY, Jong, SC & Kang, DY 2005, 'Gastrointestinal stromal tumors in Koreans: It's incidence and the clinical, pathologic and immunohistochemical findings', Journal of Korean medical science, vol. 20, no. 6, pp. 977-984. https://doi.org/10.3346/jkms.2005.20.6.977

Gastrointestinal stromal tumors in Koreans : It's incidence and the clinical, pathologic and immunohistochemical findings. / Kim, Kyoung Mee; Dong, Wook Kang; Woo, Sung Moon; Jae, Bok Park; Cheol, Keun Park; Jin, Hee Sohn; Jin, Sook Jeong; Cho, Mee Yon; Jin, So Young; Jong, Sang Choi; Kang, Dae Young.

In: Journal of Korean medical science, Vol. 20, No. 6, 12.2005, p. 977-984.

Research output: Contribution to journalArticle

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T1 - Gastrointestinal stromal tumors in Koreans

T2 - It's incidence and the clinical, pathologic and immunohistochemical findings

AU - Kim, Kyoung Mee

AU - Dong, Wook Kang

AU - Woo, Sung Moon

AU - Jae, Bok Park

AU - Cheol, Keun Park

AU - Jin, Hee Sohn

AU - Jin, Sook Jeong

AU - Cho, Mee Yon

AU - Jin, So Young

AU - Jong, Sang Choi

AU - Kang, Dae Young

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N2 - Seven hundred forty seven cases of gastrointestinal stromal tumors (GISTs) in Koreans who were diagnosed between 2001 and 2002 were analyzed to evaluate their occurrence and their clinical, pathologic and immunohistochemical findings. The most frequent location of tumor was in the stomach (63%), followed by the small intestine (30%), the colorectum (5%), and the esophagus (2%). c-kit expression was found in 93.6% of the cases, while CD34, SMA and S-100 protein was positive in 80.1%, 28.2%, and 20.2%, respectively. c-kit positivity was high in the stomach (94.2%) and small intestine (94.6%), while it was relatively low in the colorectum (85.0%), and esophagus (81.2%). The positivity for CD34 was correlated with the higher risk of GISTs (p=0.04). Follow up of the patients showed that 58 primary GISTs patients died and 20 of these patients were recurrent or metastatic at the time of diagnosis. The pathologic diagnosis to predict the risk of aggressive behavior of GISTs was correlated with the numbers of tumor, clinical stage, epithelioid histologic type, cellularity, cellular atypia, necrosis, and mucosal invasion (p=0.00). GISTs with a poor prognosis were closely related to the clinical stage at presentation, the locations of the tumor, and the ages of the patients.

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