Gd chelated PANI nanoparticles for combined MR imaging and NIR photothermal cancer therapy

Taeksu Lee, Doyeon Bang, Jinsuck Suh, yongmin Huh, Seungjoo Haam

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The ultrasensitive and selective diagnosis along with efficient therapy in earliest stage of cancer has been enormously highlighted by a better means to treat the cancer. Herein, Gd (III) chelated polyaniline nanoparticles (GPNPs) was synthesized to be served as a highly T 1 enhanced contrast agents and Near-Infrared photothermal therapy probes. In addition, therapeutic antibody was conjugated on the surface of GPNPs for the targeted theragnosis. Fabricated GPNPs significantly reduced the T 1 of water protons with as well as represented photothermal ability. The physicochemical properties and biocompatibilities of GNPSs were fully characterized and GPNPs exhibited excellent tumor targeting ability. Consequently, GPNPs exhibited strong potential for efficient diagnosis of cancer in MR imaging and photothermal ablation of epithelial cancer cells.

Original languageEnglish
Title of host publicationNanosystems in Engineering and Medicine
Volume8548
DOIs
Publication statusPublished - 2012 Dec 1
EventNanosystems in Engineering and Medicine - Incheon, Korea, Republic of
Duration: 2012 Sep 102012 Sep 12

Other

OtherNanosystems in Engineering and Medicine
CountryKorea, Republic of
CityIncheon
Period12/9/1012/9/12

Fingerprint

Nanoparticles
therapy
cancer
Imaging techniques
nanoparticles
Polyaniline
Ablation
Biocompatibility
Antibodies
Contrast Media
Protons
Tumors
Neoplasms
Cells
Infrared radiation
Water
biocompatibility
Therapeutics
antibodies
ablation

All Science Journal Classification (ASJC) codes

  • Atomic and Molecular Physics, and Optics
  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Radiology Nuclear Medicine and imaging

Cite this

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abstract = "The ultrasensitive and selective diagnosis along with efficient therapy in earliest stage of cancer has been enormously highlighted by a better means to treat the cancer. Herein, Gd (III) chelated polyaniline nanoparticles (GPNPs) was synthesized to be served as a highly T 1 enhanced contrast agents and Near-Infrared photothermal therapy probes. In addition, therapeutic antibody was conjugated on the surface of GPNPs for the targeted theragnosis. Fabricated GPNPs significantly reduced the T 1 of water protons with as well as represented photothermal ability. The physicochemical properties and biocompatibilities of GNPSs were fully characterized and GPNPs exhibited excellent tumor targeting ability. Consequently, GPNPs exhibited strong potential for efficient diagnosis of cancer in MR imaging and photothermal ablation of epithelial cancer cells.",
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Lee, T, Bang, D, Suh, J, Huh, Y & Haam, S 2012, Gd chelated PANI nanoparticles for combined MR imaging and NIR photothermal cancer therapy. in Nanosystems in Engineering and Medicine. vol. 8548, 85482E, Nanosystems in Engineering and Medicine, Incheon, Korea, Republic of, 12/9/10. https://doi.org/10.1117/12.2001967

Gd chelated PANI nanoparticles for combined MR imaging and NIR photothermal cancer therapy. / Lee, Taeksu; Bang, Doyeon; Suh, Jinsuck; Huh, yongmin; Haam, Seungjoo.

Nanosystems in Engineering and Medicine. Vol. 8548 2012. 85482E.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

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