Geant4-DNA example applications for track structure simulations in liquid water: A report from the Geant4-DNA Project

S. Incerti, I. Kyriakou, M. A. Bernal, M. C. Bordage, Z. Francis, S. Guatelli, V. Ivanchenko, M. Karamitros, N. Lampe, S. B. Lee, S. Meylan, C. H. Min, W. G. Shin, P. Nieminen, D. Sakata, N. Tang, C. Villagrasa, H. N. Tran, J. M.C. Brown

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108 Citations (Scopus)

Abstract

This Special Report presents a description of Geant4-DNA user applications dedicated to the simulation of track structures (TS) in liquid water and associated physical quantities (e.g., range, stopping power, mean free path…). These example applications are included in the Geant4 Monte Carlo toolkit and are available in open access. Each application is described and comparisons to recent international recommendations are shown (e.g., ICRU, MIRD), when available. The influence of physics models available in Geant4-DNA for the simulation of electron interactions in liquid water is discussed. Thanks to these applications, the authors show that the most recent sets of physics models available in Geant4-DNA (the so-called “option4” and “option 6” sets) enable more accurate simulation of stopping powers, dose point kernels, and W-values in liquid water, than the default set of models (“option 2”) initially provided in Geant4-DNA. They also serve as reference applications for Geant4-DNA users interested in TS simulations.

Original languageEnglish
Pages (from-to)e722-e739
JournalMedical physics
Volume45
Issue number8
DOIs
Publication statusPublished - 2018 Aug

Bibliographical note

Funding Information:
The Geant4-DNA Collaboration acknowledges the following sources of funding and support: the French National Center for Scientific Research (CNRS) Projet International de Coopération Scientifique (PICS) #7340 France–Greece (2016–2018), the University of Bordeaux Initiative of Excellence–France–International Postdoctorates program in the framework of the “France-Japan Particle Physics Laboratory” International Associated Laboratory (2016–2017) and the University of Bordeaux Initiative of Excellence–France– International Doctorates program in the framework of the “France-Korea Particle Physics Laboratory” International Associated Laboratory (2016–2019). M. A. Bernal acknowledges the support received from the Conselho Nacional para o Desenvolvimento Cientıfico e Tecnologico (CNPq) and FAPESP foundation, in Brazil, for financing his research activities through the projects 306775/2015-8 and 2011/ 51594-2, respectively. S. Guatelli and D. Sakata acknowledge the financial support of the Australian Research Council, ARC DP170100967. I. Kyriakou acknowledges financial support from European Space Agency (Contract No. 4000112863/14/NL/HB).

Funding Information:
The Geant4-DNA Collaboration acknowledges the following sources of funding and support: the French National Center for Scientific Research (CNRS) Projet International de Coop?ration Scientifique (PICS) #7340 France?Greece (2016?2018), the University of Bordeaux Initiative of Excellence?France?International Postdoctorates program in the framework of the ?France-Japan Particle Physics Laboratory? International Associated Laboratory (2016?2017) and the University of Bordeaux Initiative of Excellence?France?International Doctorates program in the framework of the ?France-Korea Particle Physics Laboratory? International Associated Laboratory (2016?2019). M. A. Bernal acknowledges the support received from the Conselho Nacional para o Desenvolvimento Cient?fico e Tecnologico (CNPq) and FAPESP foundation, in Brazil, for financing his research activities through the projects 306775/2015-8 and 2011/51594-2, respectively. S. Guatelli and D. Sakata acknowledge the financial support of the Australian Research Council, ARC DP170100967. I. Kyriakou acknowledges financial support from European Space Agency (Contract No. 4000112863/14/NL/HB).

Publisher Copyright:
© 2018 American Association of Physicists in Medicine

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Radiology Nuclear Medicine and imaging

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