Gender difference and determinants of C-reactive protein level in korean adults

Yongjae Lee, Jung Hyun Lee, Youn Ho Shin, Jong Koo Kim, Hye Ree Lee, Duk Chul Lee

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Background: C-reactive protein (CRP) has emerged as an important predictor for cardiovascular disease (CVD). To facilitate clinical and public health interventions, CRP thresholds have been defined as follows: low-risk (<1.0 mg/L), average-risk (1.0-3.0 mg/L), and high-risk (>3.0 mg/L). However, these cut-off thresholds are based on distributions in Western populations, and do not distinguish between men and women. Methods: We examined CRP distribution, gender difference, and determinants of CRP concentrations ranging from 0.02 mg/L to 10.0 mg/L, in 4923 Korean adults (2248 men; 2675 women) who received health checkups at Gangnam Severance Hospital from March 2006 to May 2007. Results: The distribution of CRP was highly skewed toward lower concentrations. CRP was higher in men than women, and the cut-off thresholds for the high-risk tertile of CRP concentrations corresponded to 1.01 mg/L in men and 0.62 mg/L in women, based on the current study population. Age, male gender, cigarette smoking, physical activity, body mass index, total cholesterol, high density lipoprotein cholesterol, γ-glutamyltransferase, and uric acid were independently associated with CRP concentrations. Conclusions: CRP distribution and gender difference in Korean adults were found to be different from previous Western studies, although similar risk factors influence CRP concentrations. Our results suggest that ethnicity and gender specific cut-off thresholds for CRP concentrations should be taken into consideration in CVD risk assessment.

Original languageEnglish
Pages (from-to)863-869
Number of pages7
JournalClinical Chemistry and Laboratory Medicine
Volume47
Issue number7
DOIs
Publication statusPublished - 2009 Jul 1

Fingerprint

C-Reactive Protein
Cardiovascular Diseases
Cholesterol
Public health
Uric Acid
Tobacco Products
Risk assessment
HDL Cholesterol
Population
Body Mass Index
Public Health
Smoking
Health
Exercise

All Science Journal Classification (ASJC) codes

  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Lee, Yongjae ; Lee, Jung Hyun ; Shin, Youn Ho ; Kim, Jong Koo ; Lee, Hye Ree ; Lee, Duk Chul. / Gender difference and determinants of C-reactive protein level in korean adults. In: Clinical Chemistry and Laboratory Medicine. 2009 ; Vol. 47, No. 7. pp. 863-869.
@article{a0b77beacc7a43c69a9abb3ddf8d4e98,
title = "Gender difference and determinants of C-reactive protein level in korean adults",
abstract = "Background: C-reactive protein (CRP) has emerged as an important predictor for cardiovascular disease (CVD). To facilitate clinical and public health interventions, CRP thresholds have been defined as follows: low-risk (<1.0 mg/L), average-risk (1.0-3.0 mg/L), and high-risk (>3.0 mg/L). However, these cut-off thresholds are based on distributions in Western populations, and do not distinguish between men and women. Methods: We examined CRP distribution, gender difference, and determinants of CRP concentrations ranging from 0.02 mg/L to 10.0 mg/L, in 4923 Korean adults (2248 men; 2675 women) who received health checkups at Gangnam Severance Hospital from March 2006 to May 2007. Results: The distribution of CRP was highly skewed toward lower concentrations. CRP was higher in men than women, and the cut-off thresholds for the high-risk tertile of CRP concentrations corresponded to 1.01 mg/L in men and 0.62 mg/L in women, based on the current study population. Age, male gender, cigarette smoking, physical activity, body mass index, total cholesterol, high density lipoprotein cholesterol, γ-glutamyltransferase, and uric acid were independently associated with CRP concentrations. Conclusions: CRP distribution and gender difference in Korean adults were found to be different from previous Western studies, although similar risk factors influence CRP concentrations. Our results suggest that ethnicity and gender specific cut-off thresholds for CRP concentrations should be taken into consideration in CVD risk assessment.",
author = "Yongjae Lee and Lee, {Jung Hyun} and Shin, {Youn Ho} and Kim, {Jong Koo} and Lee, {Hye Ree} and Lee, {Duk Chul}",
year = "2009",
month = "7",
day = "1",
doi = "10.1515/CCLM.2009.196",
language = "English",
volume = "47",
pages = "863--869",
journal = "Clinical Chemistry and Laboratory Medicine",
issn = "1434-6621",
publisher = "Walter de Gruyter GmbH & Co. KG",
number = "7",

}

Gender difference and determinants of C-reactive protein level in korean adults. / Lee, Yongjae; Lee, Jung Hyun; Shin, Youn Ho; Kim, Jong Koo; Lee, Hye Ree; Lee, Duk Chul.

In: Clinical Chemistry and Laboratory Medicine, Vol. 47, No. 7, 01.07.2009, p. 863-869.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gender difference and determinants of C-reactive protein level in korean adults

AU - Lee, Yongjae

AU - Lee, Jung Hyun

AU - Shin, Youn Ho

AU - Kim, Jong Koo

AU - Lee, Hye Ree

AU - Lee, Duk Chul

PY - 2009/7/1

Y1 - 2009/7/1

N2 - Background: C-reactive protein (CRP) has emerged as an important predictor for cardiovascular disease (CVD). To facilitate clinical and public health interventions, CRP thresholds have been defined as follows: low-risk (<1.0 mg/L), average-risk (1.0-3.0 mg/L), and high-risk (>3.0 mg/L). However, these cut-off thresholds are based on distributions in Western populations, and do not distinguish between men and women. Methods: We examined CRP distribution, gender difference, and determinants of CRP concentrations ranging from 0.02 mg/L to 10.0 mg/L, in 4923 Korean adults (2248 men; 2675 women) who received health checkups at Gangnam Severance Hospital from March 2006 to May 2007. Results: The distribution of CRP was highly skewed toward lower concentrations. CRP was higher in men than women, and the cut-off thresholds for the high-risk tertile of CRP concentrations corresponded to 1.01 mg/L in men and 0.62 mg/L in women, based on the current study population. Age, male gender, cigarette smoking, physical activity, body mass index, total cholesterol, high density lipoprotein cholesterol, γ-glutamyltransferase, and uric acid were independently associated with CRP concentrations. Conclusions: CRP distribution and gender difference in Korean adults were found to be different from previous Western studies, although similar risk factors influence CRP concentrations. Our results suggest that ethnicity and gender specific cut-off thresholds for CRP concentrations should be taken into consideration in CVD risk assessment.

AB - Background: C-reactive protein (CRP) has emerged as an important predictor for cardiovascular disease (CVD). To facilitate clinical and public health interventions, CRP thresholds have been defined as follows: low-risk (<1.0 mg/L), average-risk (1.0-3.0 mg/L), and high-risk (>3.0 mg/L). However, these cut-off thresholds are based on distributions in Western populations, and do not distinguish between men and women. Methods: We examined CRP distribution, gender difference, and determinants of CRP concentrations ranging from 0.02 mg/L to 10.0 mg/L, in 4923 Korean adults (2248 men; 2675 women) who received health checkups at Gangnam Severance Hospital from March 2006 to May 2007. Results: The distribution of CRP was highly skewed toward lower concentrations. CRP was higher in men than women, and the cut-off thresholds for the high-risk tertile of CRP concentrations corresponded to 1.01 mg/L in men and 0.62 mg/L in women, based on the current study population. Age, male gender, cigarette smoking, physical activity, body mass index, total cholesterol, high density lipoprotein cholesterol, γ-glutamyltransferase, and uric acid were independently associated with CRP concentrations. Conclusions: CRP distribution and gender difference in Korean adults were found to be different from previous Western studies, although similar risk factors influence CRP concentrations. Our results suggest that ethnicity and gender specific cut-off thresholds for CRP concentrations should be taken into consideration in CVD risk assessment.

UR - http://www.scopus.com/inward/record.url?scp=67849104864&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=67849104864&partnerID=8YFLogxK

U2 - 10.1515/CCLM.2009.196

DO - 10.1515/CCLM.2009.196

M3 - Article

VL - 47

SP - 863

EP - 869

JO - Clinical Chemistry and Laboratory Medicine

JF - Clinical Chemistry and Laboratory Medicine

SN - 1434-6621

IS - 7

ER -