Gender differences in clinical features and in-hospital outcomes in ST-segment elevation acute myocardial infarction: From the Korean Acute Myocardial Infarction Registry (KAMIR) study

Jong Seon Park, Young Jo Kim, Dong Gu Shin, Myung Ho Jeong, Young Keun Ahn, Wook Sung Chung, Ki Bae Seung, Chong Jin Kim, Myeong Chan Cho, Yangsoo Jang, Seung Jung Park, In Whan Seong, Shung Chull Chae, Seung Ho Hur, Donghoon Choi, Taek Jong Hong

Research output: Contribution to journalArticle

28 Citations (Scopus)

Abstract

Background: Studies have suggested that women are biologically different and that female gender itself is independently associated with poor clinical outcome after an acute myocardial infarction (AMI). Hypothesis: We analyzed data from the Korean Acute Myocardial Infarction Registry (KAMIR) to assess gender differences in in-hospital outcomes post ST-segment elevation myocardial infarction (STEMI). Methods: Between November 2005 and July 2007, 4037 patients who were admitted with STEMI to 41 facilities were registered into the KAMIR database; patients admitted within 72 hours of symptom onset were selected and included in this study. Results: The proportion of patients who had reperfusion therapy within 12 hours from chest pain onset was lower in women. Women had higher rates of in-hospital mortality (8.6% vs 3.2%, P < .01), noncardiac death (1.5% vs 0.4%, P < .01), cardiac death (7.1% vs 2.8%, P < .01), and stroke (1.2% vs 0.5%, P < .05) than men. Multivariate logistic regression analysis identified age, previous angina, hypertension, a Killip class ≥ II, a left ventricular ejection fraction (LVEF) <40%, and a thrombolysis in myocardial infarction flow (TIMI) grade ≤3 after angioplasty as independent risk factors for in-hospital death for all patients; however, female gender itself was not an independent risk factor. Conclusions: The results of this study show that although women have a higher in-hospital mortality than men, female gender itself is not an independent risk factor for in-hospital mortality.

Original languageEnglish
JournalClinical Cardiology
Volume33
Issue number8
DOIs
Publication statusPublished - 2010 Aug 1

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Registries
Hospital Mortality
Myocardial Infarction
Chest Pain
Angioplasty
Stroke Volume
Reperfusion
Logistic Models
Stroke
Regression Analysis
Databases
Hypertension
ST Elevation Myocardial Infarction
Therapeutics

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Park, Jong Seon ; Kim, Young Jo ; Shin, Dong Gu ; Jeong, Myung Ho ; Ahn, Young Keun ; Chung, Wook Sung ; Seung, Ki Bae ; Kim, Chong Jin ; Cho, Myeong Chan ; Jang, Yangsoo ; Park, Seung Jung ; Seong, In Whan ; Chae, Shung Chull ; Hur, Seung Ho ; Choi, Donghoon ; Hong, Taek Jong. / Gender differences in clinical features and in-hospital outcomes in ST-segment elevation acute myocardial infarction : From the Korean Acute Myocardial Infarction Registry (KAMIR) study. In: Clinical Cardiology. 2010 ; Vol. 33, No. 8.
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title = "Gender differences in clinical features and in-hospital outcomes in ST-segment elevation acute myocardial infarction: From the Korean Acute Myocardial Infarction Registry (KAMIR) study",
abstract = "Background: Studies have suggested that women are biologically different and that female gender itself is independently associated with poor clinical outcome after an acute myocardial infarction (AMI). Hypothesis: We analyzed data from the Korean Acute Myocardial Infarction Registry (KAMIR) to assess gender differences in in-hospital outcomes post ST-segment elevation myocardial infarction (STEMI). Methods: Between November 2005 and July 2007, 4037 patients who were admitted with STEMI to 41 facilities were registered into the KAMIR database; patients admitted within 72 hours of symptom onset were selected and included in this study. Results: The proportion of patients who had reperfusion therapy within 12 hours from chest pain onset was lower in women. Women had higher rates of in-hospital mortality (8.6{\%} vs 3.2{\%}, P < .01), noncardiac death (1.5{\%} vs 0.4{\%}, P < .01), cardiac death (7.1{\%} vs 2.8{\%}, P < .01), and stroke (1.2{\%} vs 0.5{\%}, P < .05) than men. Multivariate logistic regression analysis identified age, previous angina, hypertension, a Killip class ≥ II, a left ventricular ejection fraction (LVEF) <40{\%}, and a thrombolysis in myocardial infarction flow (TIMI) grade ≤3 after angioplasty as independent risk factors for in-hospital death for all patients; however, female gender itself was not an independent risk factor. Conclusions: The results of this study show that although women have a higher in-hospital mortality than men, female gender itself is not an independent risk factor for in-hospital mortality.",
author = "Park, {Jong Seon} and Kim, {Young Jo} and Shin, {Dong Gu} and Jeong, {Myung Ho} and Ahn, {Young Keun} and Chung, {Wook Sung} and Seung, {Ki Bae} and Kim, {Chong Jin} and Cho, {Myeong Chan} and Yangsoo Jang and Park, {Seung Jung} and Seong, {In Whan} and Chae, {Shung Chull} and Hur, {Seung Ho} and Donghoon Choi and Hong, {Taek Jong}",
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Gender differences in clinical features and in-hospital outcomes in ST-segment elevation acute myocardial infarction : From the Korean Acute Myocardial Infarction Registry (KAMIR) study. / Park, Jong Seon; Kim, Young Jo; Shin, Dong Gu; Jeong, Myung Ho; Ahn, Young Keun; Chung, Wook Sung; Seung, Ki Bae; Kim, Chong Jin; Cho, Myeong Chan; Jang, Yangsoo; Park, Seung Jung; Seong, In Whan; Chae, Shung Chull; Hur, Seung Ho; Choi, Donghoon; Hong, Taek Jong.

In: Clinical Cardiology, Vol. 33, No. 8, 01.08.2010.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gender differences in clinical features and in-hospital outcomes in ST-segment elevation acute myocardial infarction

T2 - From the Korean Acute Myocardial Infarction Registry (KAMIR) study

AU - Park, Jong Seon

AU - Kim, Young Jo

AU - Shin, Dong Gu

AU - Jeong, Myung Ho

AU - Ahn, Young Keun

AU - Chung, Wook Sung

AU - Seung, Ki Bae

AU - Kim, Chong Jin

AU - Cho, Myeong Chan

AU - Jang, Yangsoo

AU - Park, Seung Jung

AU - Seong, In Whan

AU - Chae, Shung Chull

AU - Hur, Seung Ho

AU - Choi, Donghoon

AU - Hong, Taek Jong

PY - 2010/8/1

Y1 - 2010/8/1

N2 - Background: Studies have suggested that women are biologically different and that female gender itself is independently associated with poor clinical outcome after an acute myocardial infarction (AMI). Hypothesis: We analyzed data from the Korean Acute Myocardial Infarction Registry (KAMIR) to assess gender differences in in-hospital outcomes post ST-segment elevation myocardial infarction (STEMI). Methods: Between November 2005 and July 2007, 4037 patients who were admitted with STEMI to 41 facilities were registered into the KAMIR database; patients admitted within 72 hours of symptom onset were selected and included in this study. Results: The proportion of patients who had reperfusion therapy within 12 hours from chest pain onset was lower in women. Women had higher rates of in-hospital mortality (8.6% vs 3.2%, P < .01), noncardiac death (1.5% vs 0.4%, P < .01), cardiac death (7.1% vs 2.8%, P < .01), and stroke (1.2% vs 0.5%, P < .05) than men. Multivariate logistic regression analysis identified age, previous angina, hypertension, a Killip class ≥ II, a left ventricular ejection fraction (LVEF) <40%, and a thrombolysis in myocardial infarction flow (TIMI) grade ≤3 after angioplasty as independent risk factors for in-hospital death for all patients; however, female gender itself was not an independent risk factor. Conclusions: The results of this study show that although women have a higher in-hospital mortality than men, female gender itself is not an independent risk factor for in-hospital mortality.

AB - Background: Studies have suggested that women are biologically different and that female gender itself is independently associated with poor clinical outcome after an acute myocardial infarction (AMI). Hypothesis: We analyzed data from the Korean Acute Myocardial Infarction Registry (KAMIR) to assess gender differences in in-hospital outcomes post ST-segment elevation myocardial infarction (STEMI). Methods: Between November 2005 and July 2007, 4037 patients who were admitted with STEMI to 41 facilities were registered into the KAMIR database; patients admitted within 72 hours of symptom onset were selected and included in this study. Results: The proportion of patients who had reperfusion therapy within 12 hours from chest pain onset was lower in women. Women had higher rates of in-hospital mortality (8.6% vs 3.2%, P < .01), noncardiac death (1.5% vs 0.4%, P < .01), cardiac death (7.1% vs 2.8%, P < .01), and stroke (1.2% vs 0.5%, P < .05) than men. Multivariate logistic regression analysis identified age, previous angina, hypertension, a Killip class ≥ II, a left ventricular ejection fraction (LVEF) <40%, and a thrombolysis in myocardial infarction flow (TIMI) grade ≤3 after angioplasty as independent risk factors for in-hospital death for all patients; however, female gender itself was not an independent risk factor. Conclusions: The results of this study show that although women have a higher in-hospital mortality than men, female gender itself is not an independent risk factor for in-hospital mortality.

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DO - 10.1002/clc.20557

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