Gender differences of in-hospital outcomes in patients undergoing percutaneous coronary intervention in the drug-eluting stent era

Hack Lyoung Kim, Jae Sik Jang, Myung A. Kim, Jae Bin Seo, Woo Young Chung, Sang Hyun Kim, Seung Jung Park, Tae Jin Youn, Myeong Ho Yoon, Jae Hwan Lee, Kiyuk Chang, Myung Ho Jeong, Rak Kyeong Choi, Myeongki Hong, Hyo Soo Kim

Research output: Contribution to journalArticle

Abstract

Most studies on gender difference of the in-hospital outcome of percutaneous coronary intervention (PCI) were performed in the pre-drug-eluting stents (DES) era. This study was performed to investigate whether gender influences the in-hospital outcome of PCI in the DES era.A total of 44,967 PCI procedure between January and December of 2014 from the nationwide PCI registry database in Korea were analyzed. The study population was male predominant (70.2%). We examined the association of gender with unadjusted and adjusted in-hospital mortality and composite events of PCI, including mortality, nonfatal myocardial infarction, stent thrombosis, stroke, urgent repeat PCI and bleeding requiring transfusion.Most of the study patients (91.3%) received DES. The incidence rates of in-hospital mortality (2.95% vs 1.99%, P <.001) and composite events (7.01% vs 5.48%, P <.001) were significantly higher in women compared to men. Unadjusted analyses showed that women had a 1.49 times higher risk of in-hospital mortality and a 1.30 times higher risk of composite events than men (P <.001 for each). After adjustment for potential confounders, female gender was not a risk factor for mortality (P = .258), but the risk of composite events remained 1.20 times higher in women than in men (P = .008).Among patients undergoing PCI in the contemporary DES era, female gender was associated with an increased risk of in-hospital composite events, but not in-hospital mortality. More careful attention should be emphasized to minimize procedure-related risks and to improve prognosis in women undergoing PCI.

Original languageEnglish
Pages (from-to)e15557
JournalMedicine
Volume98
Issue number20
DOIs
Publication statusPublished - 2019 May 1

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Drug-Eluting Stents
Percutaneous Coronary Intervention
Hospital Mortality
Mortality
Korea
Stents
Registries
Thrombosis
Stroke
Myocardial Infarction
Databases
Hemorrhage
Incidence

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Kim, Hack Lyoung ; Jang, Jae Sik ; Kim, Myung A. ; Seo, Jae Bin ; Chung, Woo Young ; Kim, Sang Hyun ; Park, Seung Jung ; Youn, Tae Jin ; Yoon, Myeong Ho ; Lee, Jae Hwan ; Chang, Kiyuk ; Jeong, Myung Ho ; Choi, Rak Kyeong ; Hong, Myeongki ; Kim, Hyo Soo. / Gender differences of in-hospital outcomes in patients undergoing percutaneous coronary intervention in the drug-eluting stent era. In: Medicine. 2019 ; Vol. 98, No. 20. pp. e15557.
@article{43bb81cd3bda437eaee58fe83a37ed24,
title = "Gender differences of in-hospital outcomes in patients undergoing percutaneous coronary intervention in the drug-eluting stent era",
abstract = "Most studies on gender difference of the in-hospital outcome of percutaneous coronary intervention (PCI) were performed in the pre-drug-eluting stents (DES) era. This study was performed to investigate whether gender influences the in-hospital outcome of PCI in the DES era.A total of 44,967 PCI procedure between January and December of 2014 from the nationwide PCI registry database in Korea were analyzed. The study population was male predominant (70.2{\%}). We examined the association of gender with unadjusted and adjusted in-hospital mortality and composite events of PCI, including mortality, nonfatal myocardial infarction, stent thrombosis, stroke, urgent repeat PCI and bleeding requiring transfusion.Most of the study patients (91.3{\%}) received DES. The incidence rates of in-hospital mortality (2.95{\%} vs 1.99{\%}, P <.001) and composite events (7.01{\%} vs 5.48{\%}, P <.001) were significantly higher in women compared to men. Unadjusted analyses showed that women had a 1.49 times higher risk of in-hospital mortality and a 1.30 times higher risk of composite events than men (P <.001 for each). After adjustment for potential confounders, female gender was not a risk factor for mortality (P = .258), but the risk of composite events remained 1.20 times higher in women than in men (P = .008).Among patients undergoing PCI in the contemporary DES era, female gender was associated with an increased risk of in-hospital composite events, but not in-hospital mortality. More careful attention should be emphasized to minimize procedure-related risks and to improve prognosis in women undergoing PCI.",
author = "Kim, {Hack Lyoung} and Jang, {Jae Sik} and Kim, {Myung A.} and Seo, {Jae Bin} and Chung, {Woo Young} and Kim, {Sang Hyun} and Park, {Seung Jung} and Youn, {Tae Jin} and Yoon, {Myeong Ho} and Lee, {Jae Hwan} and Kiyuk Chang and Jeong, {Myung Ho} and Choi, {Rak Kyeong} and Myeongki Hong and Kim, {Hyo Soo}",
year = "2019",
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Kim, HL, Jang, JS, Kim, MA, Seo, JB, Chung, WY, Kim, SH, Park, SJ, Youn, TJ, Yoon, MH, Lee, JH, Chang, K, Jeong, MH, Choi, RK, Hong, M & Kim, HS 2019, 'Gender differences of in-hospital outcomes in patients undergoing percutaneous coronary intervention in the drug-eluting stent era', Medicine, vol. 98, no. 20, pp. e15557. https://doi.org/10.1097/MD.0000000000015557

Gender differences of in-hospital outcomes in patients undergoing percutaneous coronary intervention in the drug-eluting stent era. / Kim, Hack Lyoung; Jang, Jae Sik; Kim, Myung A.; Seo, Jae Bin; Chung, Woo Young; Kim, Sang Hyun; Park, Seung Jung; Youn, Tae Jin; Yoon, Myeong Ho; Lee, Jae Hwan; Chang, Kiyuk; Jeong, Myung Ho; Choi, Rak Kyeong; Hong, Myeongki; Kim, Hyo Soo.

In: Medicine, Vol. 98, No. 20, 01.05.2019, p. e15557.

Research output: Contribution to journalArticle

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T1 - Gender differences of in-hospital outcomes in patients undergoing percutaneous coronary intervention in the drug-eluting stent era

AU - Kim, Hack Lyoung

AU - Jang, Jae Sik

AU - Kim, Myung A.

AU - Seo, Jae Bin

AU - Chung, Woo Young

AU - Kim, Sang Hyun

AU - Park, Seung Jung

AU - Youn, Tae Jin

AU - Yoon, Myeong Ho

AU - Lee, Jae Hwan

AU - Chang, Kiyuk

AU - Jeong, Myung Ho

AU - Choi, Rak Kyeong

AU - Hong, Myeongki

AU - Kim, Hyo Soo

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Most studies on gender difference of the in-hospital outcome of percutaneous coronary intervention (PCI) were performed in the pre-drug-eluting stents (DES) era. This study was performed to investigate whether gender influences the in-hospital outcome of PCI in the DES era.A total of 44,967 PCI procedure between January and December of 2014 from the nationwide PCI registry database in Korea were analyzed. The study population was male predominant (70.2%). We examined the association of gender with unadjusted and adjusted in-hospital mortality and composite events of PCI, including mortality, nonfatal myocardial infarction, stent thrombosis, stroke, urgent repeat PCI and bleeding requiring transfusion.Most of the study patients (91.3%) received DES. The incidence rates of in-hospital mortality (2.95% vs 1.99%, P <.001) and composite events (7.01% vs 5.48%, P <.001) were significantly higher in women compared to men. Unadjusted analyses showed that women had a 1.49 times higher risk of in-hospital mortality and a 1.30 times higher risk of composite events than men (P <.001 for each). After adjustment for potential confounders, female gender was not a risk factor for mortality (P = .258), but the risk of composite events remained 1.20 times higher in women than in men (P = .008).Among patients undergoing PCI in the contemporary DES era, female gender was associated with an increased risk of in-hospital composite events, but not in-hospital mortality. More careful attention should be emphasized to minimize procedure-related risks and to improve prognosis in women undergoing PCI.

AB - Most studies on gender difference of the in-hospital outcome of percutaneous coronary intervention (PCI) were performed in the pre-drug-eluting stents (DES) era. This study was performed to investigate whether gender influences the in-hospital outcome of PCI in the DES era.A total of 44,967 PCI procedure between January and December of 2014 from the nationwide PCI registry database in Korea were analyzed. The study population was male predominant (70.2%). We examined the association of gender with unadjusted and adjusted in-hospital mortality and composite events of PCI, including mortality, nonfatal myocardial infarction, stent thrombosis, stroke, urgent repeat PCI and bleeding requiring transfusion.Most of the study patients (91.3%) received DES. The incidence rates of in-hospital mortality (2.95% vs 1.99%, P <.001) and composite events (7.01% vs 5.48%, P <.001) were significantly higher in women compared to men. Unadjusted analyses showed that women had a 1.49 times higher risk of in-hospital mortality and a 1.30 times higher risk of composite events than men (P <.001 for each). After adjustment for potential confounders, female gender was not a risk factor for mortality (P = .258), but the risk of composite events remained 1.20 times higher in women than in men (P = .008).Among patients undergoing PCI in the contemporary DES era, female gender was associated with an increased risk of in-hospital composite events, but not in-hospital mortality. More careful attention should be emphasized to minimize procedure-related risks and to improve prognosis in women undergoing PCI.

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