Gender-related differences in management of nonvalvular atrial fibrillation in an asian population

Jung Myung Lee, Tae Hoon Kim, Myung Jin Cha, Junbeom Park, Jin Kyu Park, Ki Woon Kang, Jaemin Shim, Jae Sun Uhm, Jun Kim, Hyung Wook Park, Young Soo Lee, Eue Keun Choi, Chang Soo Kim, Boyoung Joung, Jin Bae Kim

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background and Objectives: Gender-related differences in health care utilization for atrial fbrillation (AF) are increasingly recognized. However, large cohort data for examining gender-related differences in AF are lacking in Asian populations. Methods: The Registry for Comparison Study of Drugs for Symptom Control and Complication Prevention of AF (CODE-AF Registry) is a prospective observational cohort-study that enrolled participants at 10 tertiary hospitals in South Korea. Baseline characteristics retrieved from the CODE-AF Registry were analyzed. Results: A total of 6,274 patients were recruited (mean age 67±11 years, mean CHA2DS2-VASc score 2.7±1.7, 63% male, 65% paroxysmal AF) from June 2016 to April 2017. Women underwent less electric cardioversion (12.3% vs. 19.6%, p<0.001), less radiofrequency ablation (12.4% vs. 17.9%, p<0.001), and less antiarrhythmic drug therapy (44.7% vs. 49.5%, p<0.001), despite having more severe symptoms (symptom class III or IV, 45.8% vs. 37.5%, p<0.001). Among patients with a CHA2DS2-VA score of 2 or more, a slightly higher proportion of women were taking oral anticoagulants than men (85.7% vs. 81.9%, p=0.002), and nonvitamin K antagonist oral anticoagulant (NOAC) use was more prevalent in women than men (70.4% vs. 62.3%, p<0.001). Insufcient NOAC dosing was very common, more so in women than men (61.5% vs. 56.3%, p<0.001). Conclusions: Female patients with AF were treated more conservatively and rhythm control strategies were used less frequently than in males, even though the female patients with AF had more severe symptoms. While insufcient NOAC dosing was common in both sex, it was signifcantly more frequent in women.

Original languageEnglish
Pages (from-to)519-528
Number of pages10
JournalKorean Circulation Journal
Volume48
Issue number6
DOIs
Publication statusPublished - 2018 Jun

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Atrial Fibrillation
Anticoagulants
Registries
Population
Patient Acceptance of Health Care
Republic of Korea
Electric Countershock
Drug and Narcotic Control
Anti-Arrhythmia Agents
Tertiary Care Centers
Observational Studies
Cohort Studies
Drug Therapy

All Science Journal Classification (ASJC) codes

  • Internal Medicine
  • Cardiology and Cardiovascular Medicine

Cite this

Lee, J. M., Kim, T. H., Cha, M. J., Park, J., Park, J. K., Kang, K. W., ... Kim, J. B. (2018). Gender-related differences in management of nonvalvular atrial fibrillation in an asian population. Korean Circulation Journal, 48(6), 519-528. https://doi.org/10.4070/kcj.2017.0389
Lee, Jung Myung ; Kim, Tae Hoon ; Cha, Myung Jin ; Park, Junbeom ; Park, Jin Kyu ; Kang, Ki Woon ; Shim, Jaemin ; Uhm, Jae Sun ; Kim, Jun ; Park, Hyung Wook ; Lee, Young Soo ; Choi, Eue Keun ; Kim, Chang Soo ; Joung, Boyoung ; Kim, Jin Bae. / Gender-related differences in management of nonvalvular atrial fibrillation in an asian population. In: Korean Circulation Journal. 2018 ; Vol. 48, No. 6. pp. 519-528.
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abstract = "Background and Objectives: Gender-related differences in health care utilization for atrial fbrillation (AF) are increasingly recognized. However, large cohort data for examining gender-related differences in AF are lacking in Asian populations. Methods: The Registry for Comparison Study of Drugs for Symptom Control and Complication Prevention of AF (CODE-AF Registry) is a prospective observational cohort-study that enrolled participants at 10 tertiary hospitals in South Korea. Baseline characteristics retrieved from the CODE-AF Registry were analyzed. Results: A total of 6,274 patients were recruited (mean age 67±11 years, mean CHA2DS2-VASc score 2.7±1.7, 63{\%} male, 65{\%} paroxysmal AF) from June 2016 to April 2017. Women underwent less electric cardioversion (12.3{\%} vs. 19.6{\%}, p<0.001), less radiofrequency ablation (12.4{\%} vs. 17.9{\%}, p<0.001), and less antiarrhythmic drug therapy (44.7{\%} vs. 49.5{\%}, p<0.001), despite having more severe symptoms (symptom class III or IV, 45.8{\%} vs. 37.5{\%}, p<0.001). Among patients with a CHA2DS2-VA score of 2 or more, a slightly higher proportion of women were taking oral anticoagulants than men (85.7{\%} vs. 81.9{\%}, p=0.002), and nonvitamin K antagonist oral anticoagulant (NOAC) use was more prevalent in women than men (70.4{\%} vs. 62.3{\%}, p<0.001). Insufcient NOAC dosing was very common, more so in women than men (61.5{\%} vs. 56.3{\%}, p<0.001). Conclusions: Female patients with AF were treated more conservatively and rhythm control strategies were used less frequently than in males, even though the female patients with AF had more severe symptoms. While insufcient NOAC dosing was common in both sex, it was signifcantly more frequent in women.",
author = "Lee, {Jung Myung} and Kim, {Tae Hoon} and Cha, {Myung Jin} and Junbeom Park and Park, {Jin Kyu} and Kang, {Ki Woon} and Jaemin Shim and Uhm, {Jae Sun} and Jun Kim and Park, {Hyung Wook} and Lee, {Young Soo} and Choi, {Eue Keun} and Kim, {Chang Soo} and Boyoung Joung and Kim, {Jin Bae}",
year = "2018",
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language = "English",
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Lee, JM, Kim, TH, Cha, MJ, Park, J, Park, JK, Kang, KW, Shim, J, Uhm, JS, Kim, J, Park, HW, Lee, YS, Choi, EK, Kim, CS, Joung, B & Kim, JB 2018, 'Gender-related differences in management of nonvalvular atrial fibrillation in an asian population', Korean Circulation Journal, vol. 48, no. 6, pp. 519-528. https://doi.org/10.4070/kcj.2017.0389

Gender-related differences in management of nonvalvular atrial fibrillation in an asian population. / Lee, Jung Myung; Kim, Tae Hoon; Cha, Myung Jin; Park, Junbeom; Park, Jin Kyu; Kang, Ki Woon; Shim, Jaemin; Uhm, Jae Sun; Kim, Jun; Park, Hyung Wook; Lee, Young Soo; Choi, Eue Keun; Kim, Chang Soo; Joung, Boyoung; Kim, Jin Bae.

In: Korean Circulation Journal, Vol. 48, No. 6, 06.2018, p. 519-528.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Gender-related differences in management of nonvalvular atrial fibrillation in an asian population

AU - Lee, Jung Myung

AU - Kim, Tae Hoon

AU - Cha, Myung Jin

AU - Park, Junbeom

AU - Park, Jin Kyu

AU - Kang, Ki Woon

AU - Shim, Jaemin

AU - Uhm, Jae Sun

AU - Kim, Jun

AU - Park, Hyung Wook

AU - Lee, Young Soo

AU - Choi, Eue Keun

AU - Kim, Chang Soo

AU - Joung, Boyoung

AU - Kim, Jin Bae

PY - 2018/6

Y1 - 2018/6

N2 - Background and Objectives: Gender-related differences in health care utilization for atrial fbrillation (AF) are increasingly recognized. However, large cohort data for examining gender-related differences in AF are lacking in Asian populations. Methods: The Registry for Comparison Study of Drugs for Symptom Control and Complication Prevention of AF (CODE-AF Registry) is a prospective observational cohort-study that enrolled participants at 10 tertiary hospitals in South Korea. Baseline characteristics retrieved from the CODE-AF Registry were analyzed. Results: A total of 6,274 patients were recruited (mean age 67±11 years, mean CHA2DS2-VASc score 2.7±1.7, 63% male, 65% paroxysmal AF) from June 2016 to April 2017. Women underwent less electric cardioversion (12.3% vs. 19.6%, p<0.001), less radiofrequency ablation (12.4% vs. 17.9%, p<0.001), and less antiarrhythmic drug therapy (44.7% vs. 49.5%, p<0.001), despite having more severe symptoms (symptom class III or IV, 45.8% vs. 37.5%, p<0.001). Among patients with a CHA2DS2-VA score of 2 or more, a slightly higher proportion of women were taking oral anticoagulants than men (85.7% vs. 81.9%, p=0.002), and nonvitamin K antagonist oral anticoagulant (NOAC) use was more prevalent in women than men (70.4% vs. 62.3%, p<0.001). Insufcient NOAC dosing was very common, more so in women than men (61.5% vs. 56.3%, p<0.001). Conclusions: Female patients with AF were treated more conservatively and rhythm control strategies were used less frequently than in males, even though the female patients with AF had more severe symptoms. While insufcient NOAC dosing was common in both sex, it was signifcantly more frequent in women.

AB - Background and Objectives: Gender-related differences in health care utilization for atrial fbrillation (AF) are increasingly recognized. However, large cohort data for examining gender-related differences in AF are lacking in Asian populations. Methods: The Registry for Comparison Study of Drugs for Symptom Control and Complication Prevention of AF (CODE-AF Registry) is a prospective observational cohort-study that enrolled participants at 10 tertiary hospitals in South Korea. Baseline characteristics retrieved from the CODE-AF Registry were analyzed. Results: A total of 6,274 patients were recruited (mean age 67±11 years, mean CHA2DS2-VASc score 2.7±1.7, 63% male, 65% paroxysmal AF) from June 2016 to April 2017. Women underwent less electric cardioversion (12.3% vs. 19.6%, p<0.001), less radiofrequency ablation (12.4% vs. 17.9%, p<0.001), and less antiarrhythmic drug therapy (44.7% vs. 49.5%, p<0.001), despite having more severe symptoms (symptom class III or IV, 45.8% vs. 37.5%, p<0.001). Among patients with a CHA2DS2-VA score of 2 or more, a slightly higher proportion of women were taking oral anticoagulants than men (85.7% vs. 81.9%, p=0.002), and nonvitamin K antagonist oral anticoagulant (NOAC) use was more prevalent in women than men (70.4% vs. 62.3%, p<0.001). Insufcient NOAC dosing was very common, more so in women than men (61.5% vs. 56.3%, p<0.001). Conclusions: Female patients with AF were treated more conservatively and rhythm control strategies were used less frequently than in males, even though the female patients with AF had more severe symptoms. While insufcient NOAC dosing was common in both sex, it was signifcantly more frequent in women.

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