Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Gyu Bum Yeon, Daryeon Son, Phil Jun Kang, Seung Min Oh, Hun Lim, Hoon Chul Kang, Seungkwon You, Dae Sung Kim

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1 Citation (Scopus)

Abstract

X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.

Original languageEnglish
Article number101425
JournalStem Cell Research
Volume36
DOIs
Publication statusPublished - 2019 Apr

Bibliographical note

Funding Information:
This work was supported by 1) the Bio & Medical Technology Development Program of the National Research Foundation of Korea funded by the Korea Ministry of Science, ICT ( MSIT ) ( 2015M3A9B4071074 and 2015M3A9B4071076 ), 2) a Korea University Research Grant, 3) BK21 PLUS Program for Biotechnology, Korea University .

Publisher Copyright:
© 2019

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

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