Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Gyu Bum Yeon; Daryeon Son; Phil Jun Kang; Seung Min Oh; Hun Lim; Hoon Chul Kang; Seungkwon You; Dae Sung Kim

doi:10.1016/j.scr.2019.101425

Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Gyu Bum Yeon, Daryeon Son, Phil Jun Kang, Seung Min Oh, Hun Lim, Hoon Chul Kang, Seungkwon You, Dae Sung Kim

Department of Pediatrics

Research output: Contribution to journal › Article

Abstract

X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.

Original language	English
Article number	101425
Journal	Stem Cell Research
Volume	36
DOIs	https://doi.org/10.1016/j.scr.2019.101425
Publication status	Published - 2019 Apr

Fingerprint

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

Cite this

Yeon, G. B., Son, D., Kang, P. J., Oh, S. M., Lim, H., Kang, H. C., You, S., & Kim, D. S. (2019). Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient. Stem Cell Research, 36, [101425]. https://doi.org/10.1016/j.scr.2019.101425

@article{06e6d27d62f54f9ea5f41a7d43576a75,

title = "Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient",

abstract = "X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.",

author = "Yeon, {Gyu Bum} and Daryeon Son and Kang, {Phil Jun} and Oh, {Seung Min} and Hun Lim and Kang, {Hoon Chul} and Seungkwon You and Kim, {Dae Sung}",

year = "2019",

month = apr

doi = "10.1016/j.scr.2019.101425",

language = "English",

volume = "36",

journal = "Stem Cell Research",

issn = "1873-5061",

publisher = "Elsevier",

}

TY - JOUR

T1 - Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

AU - Yeon, Gyu Bum

AU - Son, Daryeon

AU - Kang, Phil Jun

AU - Oh, Seung Min

AU - Lim, Hun

AU - Kang, Hoon Chul

AU - You, Seungkwon

AU - Kim, Dae Sung

PY - 2019/4

Y1 - 2019/4

N2 - X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.

AB - X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.

UR - http://www.scopus.com/inward/record.url?scp=85063351189&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85063351189&partnerID=8YFLogxK

U2 - 10.1016/j.scr.2019.101425

DO - 10.1016/j.scr.2019.101425

M3 - Article

C2 - 30921588

AN - SCOPUS:85063351189

VL - 36

JO - Stem Cell Research

JF - Stem Cell Research

SN - 1873-5061

M1 - 101425

ER -

Access to Document

10.1016/j.scr.2019.101425