Abstract
X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.
| Original language | English |
|---|---|
| Article number | 101425 |
| Journal | Stem Cell Research |
| Volume | 36 |
| DOIs | |
| Publication status | Published - 2019 Apr |
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All Science Journal Classification (ASJC) codes
- Developmental Biology
- Cell Biology
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Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient. / Yeon, Gyu Bum; Son, Daryeon; Kang, Phil Jun; Oh, Seung Min; Lim, Hun; Kang, Hoon Chul; You, Seungkwon; Kim, Dae Sung.
In: Stem Cell Research, Vol. 36, 101425, 04.2019.Research output: Contribution to journal › Article
TY - JOUR
T1 - Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient
AU - Yeon, Gyu Bum
AU - Son, Daryeon
AU - Kang, Phil Jun
AU - Oh, Seung Min
AU - Lim, Hun
AU - Kang, Hoon Chul
AU - You, Seungkwon
AU - Kim, Dae Sung
PY - 2019/4
Y1 - 2019/4
N2 - X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.
AB - X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.
UR - http://www.scopus.com/inward/record.url?scp=85063351189&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85063351189&partnerID=8YFLogxK
U2 - 10.1016/j.scr.2019.101425
DO - 10.1016/j.scr.2019.101425
M3 - Article
C2 - 30921588
AN - SCOPUS:85063351189
VL - 36
JO - Stem Cell Research
JF - Stem Cell Research
SN - 1873-5061
M1 - 101425
ER -