X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.
Bibliographical noteFunding Information:
This work was supported by 1) the Bio & Medical Technology Development Program of the National Research Foundation of Korea funded by the Korea Ministry of Science, ICT ( MSIT ) ( 2015M3A9B4071074 and 2015M3A9B4071076 ), 2) a Korea University Research Grant, 3) BK21 PLUS Program for Biotechnology, Korea University .
All Science Journal Classification (ASJC) codes
- Developmental Biology
- Cell Biology