Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Gyu Bum Yeon, Daryeon Son, Phil Jun Kang, Seung Min Oh, Hun Lim, Hoon Chul Kang, Seungkwon You, Dae Sung Kim

Research output: Contribution to journalArticle

Abstract

X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.

Original languageEnglish
Article number101425
JournalStem Cell Research
Volume36
DOIs
Publication statusPublished - 2019 Apr

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Adrenoleukodystrophy
Induced Pluripotent Stem Cells
Sendai virus
Cell Line
Germ Layers
ATP-Binding Cassette Transporters
Karyotype
Fibroblasts
Skin
Genes
Proteins
In Vitro Techniques
adenosine transporter

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

Cite this

Yeon, Gyu Bum ; Son, Daryeon ; Kang, Phil Jun ; Oh, Seung Min ; Lim, Hun ; Kang, Hoon Chul ; You, Seungkwon ; Kim, Dae Sung. / Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient. In: Stem Cell Research. 2019 ; Vol. 36.
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Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient. / Yeon, Gyu Bum; Son, Daryeon; Kang, Phil Jun; Oh, Seung Min; Lim, Hun; Kang, Hoon Chul; You, Seungkwon; Kim, Dae Sung.

In: Stem Cell Research, Vol. 36, 101425, 04.2019.

Research output: Contribution to journalArticle

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AU - Son, Daryeon

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AU - Oh, Seung Min

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AU - Kang, Hoon Chul

AU - You, Seungkwon

AU - Kim, Dae Sung

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