Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Gyu Bum Yeon; Daryeon Son; Phil Jun Kang; Seung Min Oh; Hun Lim; Hoon Chul Kang; Seungkwon You; Dae Sung Kim

doi:10.1016/j.scr.2019.101425

Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Gyu Bum Yeon, Daryeon Son, Phil Jun Kang, Seung Min Oh, Hun Lim, Hoon Chul Kang, Seungkwon You, Dae Sung Kim

Department of Pediatrics

Research output: Contribution to journal › Article › peer-review

Abstract

X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.

Original language	English
Article number	101425
Journal	Stem Cell Research
Volume	36
DOIs	https://doi.org/10.1016/j.scr.2019.101425
Publication status	Published - 2019 Apr

Bibliographical note

Funding Information:
This work was supported by 1) the Bio & Medical Technology Development Program of the National Research Foundation of Korea funded by the Korea Ministry of Science, ICT ( MSIT ) ( 2015M3A9B4071074 and 2015M3A9B4071076 ), 2) a Korea University Research Grant, 3) BK21 PLUS Program for Biotechnology, Korea University .

Publisher Copyright:
© 2019

All Science Journal Classification (ASJC) codes

Developmental Biology
Cell Biology

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title = "Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient",

abstract = "X-linked Adrenoleukodystrophy (X-ALD) is a neuro-metabolic disorder that is caused by malfunction of a peroxisomal transporter protein, adenosine ATP-binding cassette transporter superfamily D member 1 (ABCD1). We established an induced pluripotent stem cell (iPSC) line from a 42-year-old male X-ALD patient-derived dermal fibroblasts with Sendai virus-mediated reprogramming. Established iPSCs stably expanded, expressed genes of pluripotency, and maintained normal karyotype. In vitro differentiation assay revealed the characteristics of all three germ layers.",

author = "Yeon, {Gyu Bum} and Daryeon Son and Kang, {Phil Jun} and Oh, {Seung Min} and Hun Lim and Kang, {Hoon Chul} and Seungkwon You and Kim, {Dae Sung}",

note = "Funding Information: This work was supported by 1) the Bio & Medical Technology Development Program of the National Research Foundation of Korea funded by the Korea Ministry of Science, ICT ( MSIT ) ( 2015M3A9B4071074 and 2015M3A9B4071076 ), 2) a Korea University Research Grant, 3) BK21 PLUS Program for Biotechnology, Korea University . Publisher Copyright: {\textcopyright} 2019",

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doi = "10.1016/j.scr.2019.101425",

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Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient. / Yeon, Gyu Bum; Son, Daryeon; Kang, Phil Jun; Oh, Seung Min; Lim, Hun; Kang, Hoon Chul; You, Seungkwon; Kim, Dae Sung.

In: Stem Cell Research, Vol. 36, 101425, 04.2019.

Research output: Contribution to journal › Article › peer-review

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AU - Son, Daryeon

AU - Kang, Phil Jun

AU - Oh, Seung Min

AU - Lim, Hun

AU - Kang, Hoon Chul

AU - You, Seungkwon

AU - Kim, Dae Sung

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Generation of an induced pluripotent stem cell (iPSC) line from a 42-year-old adult cerebral type X-linked adrenoleukodystrophy (X-ALD) patient

Abstract

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