Generation of induced pluripotent stem cells from somatic cells

Young Doug Sohn, Ji Woong Han, Young Sup Yoon

Research output: Chapter in Book/Report/Conference proceedingChapter

12 Citations (Scopus)

Abstract

The technology for generation of induced pluripotent stem cell (iPSC) from somatic cells emerged to circumvent the ethical and immunological limitations of embryonic stem cell (ESC). The recent progress of iPSC technology offers an unprecedented tool for regenerative medicine; however, integrating viral-driven iPSCs prohibits clinical applications by their genetic alterations and tumorigenicity. Various approaches including nonintegrating, nonviral, and nongenetic methods have been developed for generating clinically compatible iPSCs. In addition, approaches for using more clinically convenient or compatible source cells replacing fibroblasts have been actively pursued. While iPSC and ESC closely resemble in genomic, cell biologic, and phenotypic characteristics, these two pluripotent stem cells are not identical in terms of differentiation capacity and epigenetic features. In this chapter, we deal with the current techniques of generating iPSCs and their various characteristics.

Original languageEnglish
Title of host publicationProgress in Molecular Biology and Translational Science
PublisherElsevier B.V.
Pages1-26
Number of pages26
DOIs
Publication statusPublished - 2012

Publication series

NameProgress in Molecular Biology and Translational Science
Volume111
ISSN (Print)1877-1173

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Molecular Biology

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    Sohn, Y. D., Han, J. W., & Yoon, Y. S. (2012). Generation of induced pluripotent stem cells from somatic cells. In Progress in Molecular Biology and Translational Science (pp. 1-26). (Progress in Molecular Biology and Translational Science; Vol. 111). Elsevier B.V.. https://doi.org/10.1016/B978-0-12-398459-3.00001-0