Generation of two induced pluripotent stem cell (iPSC) lines from X-linked adrenoleukodystrophy (X-ALD) patients with adrenomyeloneuropathy (AMN)

Daryeon Son, Zhejiu Quan, Phil Jun Kang, Gyuman Park, hoonchul kang, Seungkwon You

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by a mutation in the ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene. We generated two induced pluripotent stem cell (iPSC) lines from X-ALD patients with adrenomyeloneuropathy (AMN) by Sendai virus containing OCT4, SOX2, KLF4 and c-MYC. Established iPSC lines expressed various pluripotency markers, had differentiation potential of three germ layers in vitro, had normal karyotype and retained ABCD1 mutation.

Original languageEnglish
Pages (from-to)46-49
Number of pages4
JournalStem Cell Research
Volume25
DOIs
Publication statusPublished - 2017 Dec 1

Fingerprint

Adrenoleukodystrophy
Induced Pluripotent Stem Cells
ATP-Binding Cassette Transporters
Cell Line
Sendai virus
Germ Layers
Mutation
Differentiation Antigens
Karyotype
Genes

All Science Journal Classification (ASJC) codes

  • Developmental Biology
  • Cell Biology

Cite this

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abstract = "X-linked adrenoleukodystrophy (X-ALD) is an inherited disorder caused by a mutation in the ATP-binding cassette transporter subfamily D member 1 (ABCD1) gene. We generated two induced pluripotent stem cell (iPSC) lines from X-ALD patients with adrenomyeloneuropathy (AMN) by Sendai virus containing OCT4, SOX2, KLF4 and c-MYC. Established iPSC lines expressed various pluripotency markers, had differentiation potential of three germ layers in vitro, had normal karyotype and retained ABCD1 mutation.",
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Generation of two induced pluripotent stem cell (iPSC) lines from X-linked adrenoleukodystrophy (X-ALD) patients with adrenomyeloneuropathy (AMN). / Son, Daryeon; Quan, Zhejiu; Kang, Phil Jun; Park, Gyuman; kang, hoonchul; You, Seungkwon.

In: Stem Cell Research, Vol. 25, 01.12.2017, p. 46-49.

Research output: Contribution to journalArticle

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AU - You, Seungkwon

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