Genetic mechanisms of aspirin hypersensitivity

Hae Sim Park, Gyu Young Hur, Seung Hyun Kim, Young Min Ye, Sangha Kim

Research output: Contribution to journalArticle

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Abstract

Background: The clinical features of aspirin hypersensitivity include aspirin-intolerant asthma (AIA) and aspirin-induced acute or chronic urticaria/angioedema (AIAU or AICU). Since it is reported that leukotriene C4 synthase (LTC4S) promoter polymorphism is related to the imbalance of leukotriene synthetic pathways, several groups have investigated the molecular genetic mechanisms of AIA, including leukotriene-related genes. In AIU, recent studies suggest overproduction of cysteinyl leukotrienes (Cys-LTs) as one of the pathogenic mechanisms. We summarize recent findings on the molecular genetic mechanism of two representative phenotypes of ASA hypersensitivity, AIA and/or AIU. Methods/Data base: An analysis of own and literature-derived results of studies examining the genetic factors of aspirin hypersensitivity. Results: In AIA, the major pathogenic mechanism was known as overproduction of Cys-LTs with increased expression of cysteinyl leukotriene receptor 1. Association with genetic polymorphisms of CYSLTR1, PGE2, TXA2R, and CYSLTR2 were newly suggested in the pathogenesis of AIA. Several single nucleotide polymorphisms (SNPs) in the promoters of EP2, TBX21, COX-2, FcεRIβ, and TXA2R were also associated with AIA. In AIU, the genetic polymorphisms of ALOX5 and FcεRIα promoter were noted. A human leukocyte antigen (HLA) study suggested that DPB1*0301 is a strong genetic marker for AIA, and that HLA DRB1*1302 and DQB1*0609 are susceptible markers for AIU. Conclusion: Recent findings suggest that several key genes involved in leukotriene synthetic pathways could contribute to the development of ASA hypersensitivity. The identification of genetic markers for susceptibility to ASA hypersensitivity with supporting functional studies would help to further elucidate its pathogenic mechanism, which could make it possible to develop early diagnostic markers and provide therapeutic targets.

Original languageEnglish
Pages (from-to)150-153
Number of pages4
JournalAllergy and Clinical Immunology International
Volume18
Issue number4
DOIs
Publication statusPublished - 2006 Jul 1

Fingerprint

Aspirin
Hypersensitivity
Asthma
Leukotrienes
Genetic Polymorphisms
HLA Antigens
Genetic Markers
Molecular Biology
Aspirin Induced Asthma
Angioedema
Urticaria
Genetic Predisposition to Disease
Dinoprostone
Genes
Single Nucleotide Polymorphism
Databases
Phenotype
AIdUrd

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy

Cite this

Park, Hae Sim ; Hur, Gyu Young ; Kim, Seung Hyun ; Ye, Young Min ; Kim, Sangha. / Genetic mechanisms of aspirin hypersensitivity. In: Allergy and Clinical Immunology International. 2006 ; Vol. 18, No. 4. pp. 150-153.
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Genetic mechanisms of aspirin hypersensitivity. / Park, Hae Sim; Hur, Gyu Young; Kim, Seung Hyun; Ye, Young Min; Kim, Sangha.

In: Allergy and Clinical Immunology International, Vol. 18, No. 4, 01.07.2006, p. 150-153.

Research output: Contribution to journalArticle

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