Background: GWAS revealed several genomes related with atrial fibrillation (AF), such as genetic variants on chromosome 4q22, PITX2, or chromosome 16q22 (ZFHX3). We evaluated those genetic polymorphisms in Korean patients with non-familial non-valvular AF. Methods and Results: We evaluated and compared the allelic frequencies of genetic polymorphisms of chromosome 4q22, PITX2, or 16q22 (ZFHX3) in 454 patients with non-valvular AF (296 paroxysmal AF [PAF], 158 persistent AF [PeAF]) and 422 sex-matched healthy controls by direct DNA sequencing and SNaPshot™ assay. Results: 1. The 4q25 rs2200733 (OR 0.368 (0.246-0.549), p<0.0001), the PITX2 rs17042171 (OR 0.368(0.246-0.551), p<0.0001), the PITX2 rs6843082 (OR 0.234(0.15-0.366), p<0.0001), and the 16q22 rs2106261 (OR 2.439(1.62-3.672), p<0.0001) genotypes were more prevalent in patients with AF than control group. 2. In the haplotype analyses, the 4q25 rs17042171-rs2200733-rs6843082-rs10033464 A-T-G-G (OR 3.3421(1.867-5.982), p<0.0001) and 4q25 without C-C-A-G (OR 4.630 (2.924-7.299), p<0.0001) were more predisposed in AF than in control group. 3. The 16q22 rs7193343-rs2106261 16q22 A-G haplotype was more prevalent in patients with AF (OR 0.477(0.242-0.939), p=0.0322) than control group. Conclusion: This study demonstrates the Chromosom 4q25, PITX2, and 16q22 ZFHX3 polymorphisms were associated with non-familial non-valvular AF in Korean population. The 4q25 and PITX2 were closely related with Korean non-valvular AF in haplotype analyses.
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine