Genetic Predisposition to Sporadic Congenital Hearing Loss in a Pediatric Population

Jinsei Jung, Joon Suk Lee, Kyeong Jee Cho, Seyoung Yu, Joo Heon Yoon, Heon Yung Gee, Jae Young Choi

Research output: Contribution to journalArticle

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Abstract

Discriminating between inherited and non-inherited sporadic hearing loss is challenging. Here, we attempted to delineate genetic inheritance in simplex cases of severe-to-profound congenital hearing loss in Korean children. Variations in SLC26A4 and GJB2 in 28 children with bilateral severe-to-profound non-syndromic hearing loss (NSHL) without familial history were analyzed using Sanger sequencing. Genetic analysis of individuals without mutations in SLC26A4 and GJB2 was performed by whole exome sequencing (WES). Bi-allelic mutations in SLC26A4 and GJB2 were identified in 12 and 3 subjects, respectively. Of the 13 individuals without mutations in SLC26A4 and GJB2, 2 and 1 carried compound heterozygous mutations in MYO15A and CDH23, respectively. Thus, 64.3% (18/28) of individuals with NSHL were determined to be genetically predisposed. Individuals with sporadic severe-to-profound NSHL were found to mostly exhibit an autosomal recessive inheritance pattern. Novel causative candidate genes for NSHL were identified by analysis of WES data of 10 families without mutations in known causative genes. Bi-allelic mutations predisposing to NSHL were identified in 64.3% of subjects with sporadic severe-to-profound NSHL. Given that several causative genes for NSHL are still unidentified, genetic inheritance of sporadic congenital hearing loss could be more common than that indicated by our results.

Original languageEnglish
Article number45973
JournalScientific reports
Volume7
DOIs
Publication statusPublished - 2017 Apr 6

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Genetic Predisposition to Disease
Hearing Loss
Pediatrics
Population
Mutation
Exome
Genes
Inheritance Patterns
History

All Science Journal Classification (ASJC) codes

  • General

Cite this

Jung, Jinsei ; Lee, Joon Suk ; Cho, Kyeong Jee ; Yu, Seyoung ; Yoon, Joo Heon ; Gee, Heon Yung ; Choi, Jae Young. / Genetic Predisposition to Sporadic Congenital Hearing Loss in a Pediatric Population. In: Scientific reports. 2017 ; Vol. 7.
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abstract = "Discriminating between inherited and non-inherited sporadic hearing loss is challenging. Here, we attempted to delineate genetic inheritance in simplex cases of severe-to-profound congenital hearing loss in Korean children. Variations in SLC26A4 and GJB2 in 28 children with bilateral severe-to-profound non-syndromic hearing loss (NSHL) without familial history were analyzed using Sanger sequencing. Genetic analysis of individuals without mutations in SLC26A4 and GJB2 was performed by whole exome sequencing (WES). Bi-allelic mutations in SLC26A4 and GJB2 were identified in 12 and 3 subjects, respectively. Of the 13 individuals without mutations in SLC26A4 and GJB2, 2 and 1 carried compound heterozygous mutations in MYO15A and CDH23, respectively. Thus, 64.3{\%} (18/28) of individuals with NSHL were determined to be genetically predisposed. Individuals with sporadic severe-to-profound NSHL were found to mostly exhibit an autosomal recessive inheritance pattern. Novel causative candidate genes for NSHL were identified by analysis of WES data of 10 families without mutations in known causative genes. Bi-allelic mutations predisposing to NSHL were identified in 64.3{\%} of subjects with sporadic severe-to-profound NSHL. Given that several causative genes for NSHL are still unidentified, genetic inheritance of sporadic congenital hearing loss could be more common than that indicated by our results.",
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Genetic Predisposition to Sporadic Congenital Hearing Loss in a Pediatric Population. / Jung, Jinsei; Lee, Joon Suk; Cho, Kyeong Jee; Yu, Seyoung; Yoon, Joo Heon; Gee, Heon Yung; Choi, Jae Young.

In: Scientific reports, Vol. 7, 45973, 06.04.2017.

Research output: Contribution to journalArticle

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