Genetic variation in the renin-angiotensin system and response to endurance training

Joon Seol Bae, Byung Yong Kang, Kang Oh Lee, Seung-Taek Lee

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Objective: To investigate the relationship between genetic variation in the renin-angiotensin system and the effect of 12-week endurance training in Korean women. Materials and Methods: Seventeen women who participated in an endurance training program for 12 weeks were genotyped for the angiotensinogen M235T polymorphism, angiotensin II type 1 receptor A1166C polymorphism, angiotensin-converting enzyme (ACE) T-3892C polymorphism, and angiotensin II type 2 receptor C3123A polymorphism. The following clinical parameters were measured before and after the endurance training program: blood pressure, body composition, ventilatory response, total cholesterol, triglyceride, and glucose. Results: Of the genetic markers investigated, the frequency of the T allele for the ACE T-3892C polymorphism was significantly associated with the response in body mass index and VO2max after 12 weeks of endurance training (p< 0.05). None of the other polymorphisms were significantly associated with the effect of training. Conclusion: The significant association between ACE T-3892C and the change in body mass index and VO2max in Korean women are attributed to training, suggesting that this genetic variation is a useful genetic marker for clarifying the interindividual response to endurance training.

Original languageEnglish
Pages (from-to)142-146
Number of pages5
JournalMedical Principles and Practice
Volume16
Issue number2
DOIs
Publication statusPublished - 2007 Feb 1

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Peptidyl-Dipeptidase A
Renin-Angiotensin System
Genetic Markers
Body Mass Index
Angiotensin Type 2 Receptor
Education
Angiotensinogen
Angiotensin Type 1 Receptor
Body Composition
Gene Frequency
Triglycerides
Cholesterol
Blood Pressure
Glucose

All Science Journal Classification (ASJC) codes

  • Medicine(all)

Cite this

Bae, Joon Seol ; Kang, Byung Yong ; Lee, Kang Oh ; Lee, Seung-Taek. / Genetic variation in the renin-angiotensin system and response to endurance training. In: Medical Principles and Practice. 2007 ; Vol. 16, No. 2. pp. 142-146.
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Genetic variation in the renin-angiotensin system and response to endurance training. / Bae, Joon Seol; Kang, Byung Yong; Lee, Kang Oh; Lee, Seung-Taek.

In: Medical Principles and Practice, Vol. 16, No. 2, 01.02.2007, p. 142-146.

Research output: Contribution to journalArticle

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