Background: Previous investigations have suggested that genetic variations are associated with reduced lung function in early childhood. This study was conducted to evaluate the association between IL13 + 2044G → A, the functionally relevant single nucleotide polymorphism (SNP) in the gene coding IL13, and lung function in early childhood. Patients and methods: A total of 1900 subjects aged 10-18 years living in Korea, were randomly recruited. Lung function test and methacholine bronchial provocation test were performed. Multiple regression analysis adjusting for sex, age, height, atopy, and history of passive smoking was done to evaluate effect of IL13 + 2044G → A on lung function. Results: Mean (±SD) forced expiratory volume in 1 s (FEV1) was 2.66 L (±0.60) in subjects with the AA or AG genotype (n = 982) and 2.75 L (±0.57) in subjects with the GG genotype (n = 918). IL13 + 2044G → A showed a significant association with FEV1 [in the minor allele dominant model (GG vs. AG + AA), P < 0.001]. Interestingly, the association between FEV1 and IL13 + 2044G → A remained still significant in subgroup analysis according to the presence of AHR (P < 0.001 in subjects without AHR and P = 0.002 in subjects with AHR). Moreover, FEV1/FVC (forced vital capacity) ratio also showed a significant association with IL13 + 2044G → A in both groups (P < 0.001 in subjects without AHR and P < 0.001 in subjects with AHR). This cross-sectional study demonstrates that IL13 + 2044G → A is significantly associated with a reduced lung function in Korean children and adolescents.
Bibliographical noteFunding Information:
This work was supported by the Korea Health 21 R&D Project Grant 03-PJ10-PG13-GD01-0002 and the Clinical Research Center for Chronic Obstructive Airway Disease Grant 0412-CR03-0704-0001from the Korean Ministry of Health and Welfare.
All Science Journal Classification (ASJC) codes
- Pulmonary and Respiratory Medicine