Genetics of inflammatory bowel diseases: A comparison between Western and Eastern perspectives

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Inflammatory bowel disease (IBD) is a chronic relapsing intestinal inflammatory disorder with unidentified causes. Currently, studies indicate that IBD results from a complex interplay between various genetic and environmental factors that produce intestinal inflammation. However, these factors may differ for Asians and Caucasians. Thus, differences in epidemiology, genetic variants, and clinical phenotypes of IBD have been observed between the two populations. Understanding the discrepancies between data from populations with different genetic backgrounds and environmental factors may reveal fundamental aspects of IBD pathogenesis. Accordingly, this review will summarize the current knowledge of IBD genetics studied in Asian countries and compare it with that from Western countries, with special focus on innate bacterial sensing, autophagy, and the interleukin-23 receptor-T helper cell 17 pathway. The epigenetic nature of IBD pathogenesis as well as the pharmacogenetics related to the use of immunomodulators will also be briefly covered.

Original languageEnglish
Pages (from-to)220-226
Number of pages7
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume28
Issue number2
DOIs
Publication statusPublished - 2013 Jan 1

Fingerprint

Inflammatory Bowel Diseases
Interleukin Receptors
Interleukin-23
Th17 Cells
Molecular Epidemiology
Pharmacogenetics
Autophagy
Immunologic Factors
Epigenomics
Population
Inflammation
Phenotype

All Science Journal Classification (ASJC) codes

  • Gastroenterology
  • Hepatology

Cite this

@article{139eea0abc9545ea96f31f47178f60d7,
title = "Genetics of inflammatory bowel diseases: A comparison between Western and Eastern perspectives",
abstract = "Inflammatory bowel disease (IBD) is a chronic relapsing intestinal inflammatory disorder with unidentified causes. Currently, studies indicate that IBD results from a complex interplay between various genetic and environmental factors that produce intestinal inflammation. However, these factors may differ for Asians and Caucasians. Thus, differences in epidemiology, genetic variants, and clinical phenotypes of IBD have been observed between the two populations. Understanding the discrepancies between data from populations with different genetic backgrounds and environmental factors may reveal fundamental aspects of IBD pathogenesis. Accordingly, this review will summarize the current knowledge of IBD genetics studied in Asian countries and compare it with that from Western countries, with special focus on innate bacterial sensing, autophagy, and the interleukin-23 receptor-T helper cell 17 pathway. The epigenetic nature of IBD pathogenesis as well as the pharmacogenetics related to the use of immunomodulators will also be briefly covered.",
author = "JaeHee Cheon",
year = "2013",
month = "1",
day = "1",
doi = "10.1111/jgh.12053",
language = "English",
volume = "28",
pages = "220--226",
journal = "Journal of Gastroenterology and Hepatology (Australia)",
issn = "0815-9319",
publisher = "Wiley-Blackwell",
number = "2",

}

TY - JOUR

T1 - Genetics of inflammatory bowel diseases

T2 - A comparison between Western and Eastern perspectives

AU - Cheon, JaeHee

PY - 2013/1/1

Y1 - 2013/1/1

N2 - Inflammatory bowel disease (IBD) is a chronic relapsing intestinal inflammatory disorder with unidentified causes. Currently, studies indicate that IBD results from a complex interplay between various genetic and environmental factors that produce intestinal inflammation. However, these factors may differ for Asians and Caucasians. Thus, differences in epidemiology, genetic variants, and clinical phenotypes of IBD have been observed between the two populations. Understanding the discrepancies between data from populations with different genetic backgrounds and environmental factors may reveal fundamental aspects of IBD pathogenesis. Accordingly, this review will summarize the current knowledge of IBD genetics studied in Asian countries and compare it with that from Western countries, with special focus on innate bacterial sensing, autophagy, and the interleukin-23 receptor-T helper cell 17 pathway. The epigenetic nature of IBD pathogenesis as well as the pharmacogenetics related to the use of immunomodulators will also be briefly covered.

AB - Inflammatory bowel disease (IBD) is a chronic relapsing intestinal inflammatory disorder with unidentified causes. Currently, studies indicate that IBD results from a complex interplay between various genetic and environmental factors that produce intestinal inflammation. However, these factors may differ for Asians and Caucasians. Thus, differences in epidemiology, genetic variants, and clinical phenotypes of IBD have been observed between the two populations. Understanding the discrepancies between data from populations with different genetic backgrounds and environmental factors may reveal fundamental aspects of IBD pathogenesis. Accordingly, this review will summarize the current knowledge of IBD genetics studied in Asian countries and compare it with that from Western countries, with special focus on innate bacterial sensing, autophagy, and the interleukin-23 receptor-T helper cell 17 pathway. The epigenetic nature of IBD pathogenesis as well as the pharmacogenetics related to the use of immunomodulators will also be briefly covered.

UR - http://www.scopus.com/inward/record.url?scp=84872801655&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84872801655&partnerID=8YFLogxK

U2 - 10.1111/jgh.12053

DO - 10.1111/jgh.12053

M3 - Article

C2 - 23189979

AN - SCOPUS:84872801655

VL - 28

SP - 220

EP - 226

JO - Journal of Gastroenterology and Hepatology (Australia)

JF - Journal of Gastroenterology and Hepatology (Australia)

SN - 0815-9319

IS - 2

ER -