Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans

Ji Young Lee, Sanghoon Moon, Yun Kyoung Kim, Sang Hak Lee, Bok Soo Lee, Min Young Park, Jeong Euy Park, Yangsoo Jang, Bok Ghee Han

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability in MI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of these genes with MI risk, and these associations have to be confirmed in other ethnic populations.

Original languageEnglish
Pages (from-to)1041-1046
Number of pages6
JournalJournal of Genetics
Volume96
Issue number6
DOIs
Publication statusPublished - 2017 Dec 1

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Exome
Myocardial Infarction
Genome
Genome-Wide Association Study
Genes
Research
Population

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Lee, Ji Young ; Moon, Sanghoon ; Kim, Yun Kyoung ; Lee, Sang Hak ; Lee, Bok Soo ; Park, Min Young ; Park, Jeong Euy ; Jang, Yangsoo ; Han, Bok Ghee. / Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans. In: Journal of Genetics. 2017 ; Vol. 96, No. 6. pp. 1041-1046.
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abstract = "Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability in MI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of these genes with MI risk, and these associations have to be confirmed in other ethnic populations.",
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Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans. / Lee, Ji Young; Moon, Sanghoon; Kim, Yun Kyoung; Lee, Sang Hak; Lee, Bok Soo; Park, Min Young; Park, Jeong Euy; Jang, Yangsoo; Han, Bok Ghee.

In: Journal of Genetics, Vol. 96, No. 6, 01.12.2017, p. 1041-1046.

Research output: Contribution to journalArticle

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AU - Lee, Ji Young

AU - Moon, Sanghoon

AU - Kim, Yun Kyoung

AU - Lee, Sang Hak

AU - Lee, Bok Soo

AU - Park, Min Young

AU - Park, Jeong Euy

AU - Jang, Yangsoo

AU - Han, Bok Ghee

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AB - Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability in MI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of these genes with MI risk, and these associations have to be confirmed in other ethnic populations.

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