Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans

Ji Young Lee; Sanghoon Moon; Yun Kyoung Kim; Sang Hak Lee; Bok Soo Lee; Min Young Park; Jeong Euy Park; Yangsoo Jang; Bok Ghee Han

doi:10.1007/s12041-017-0854-z

Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans

Ji Young Lee, Sanghoon Moon, Yun Kyoung Kim, Sang Hak Lee, Bok Soo Lee, Min Young Park, Jeong Euy Park, Yangsoo Jang, Bok Ghee Han

Department of Internal Medicine

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability in MI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of these genes with MI risk, and these associations have to be confirmed in other ethnic populations.

Original language	English
Pages (from-to)	1041-1046
Number of pages	6
Journal	Journal of Genetics
Volume	96
Issue number	6
DOIs	https://doi.org/10.1007/s12041-017-0854-z
Publication status	Published - 2017 Dec 1

Bibliographical note

Funding Information:
We thank all participants and investigators of the Korea Genome Epidemiology Study (KoGES). This work was supported by grants from the Korea Centers for Disease Control and Prevention (4845-301), an intramural grant from the Korea National Institute of Health (2012-N73003-00).

Publisher Copyright:
© 2017, Indian Academy of Sciences.

All Science Journal Classification (ASJC) codes

Genetics

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10.1007/s12041-017-0854-z

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title = "Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans",

abstract = "Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability in MI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of these genes with MI risk, and these associations have to be confirmed in other ethnic populations.",

author = "Lee, {Ji Young} and Sanghoon Moon and Kim, {Yun Kyoung} and Lee, {Sang Hak} and Lee, {Bok Soo} and Park, {Min Young} and Park, {Jeong Euy} and Yangsoo Jang and Han, {Bok Ghee}",

note = "Funding Information: We thank all participants and investigators of the Korea Genome Epidemiology Study (KoGES). This work was supported by grants from the Korea Centers for Disease Control and Prevention (4845-301), an intramural grant from the Korea National Institute of Health (2012-N73003-00). Publisher Copyright: {\textcopyright} 2017, Indian Academy of Sciences.",

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doi = "10.1007/s12041-017-0854-z",

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Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans. / Lee, Ji Young; Moon, Sanghoon; Kim, Yun Kyoung; Lee, Sang Hak; Lee, Bok Soo; Park, Min Young; Park, Jeong Euy; Jang, Yangsoo; Han, Bok Ghee.

In: Journal of Genetics, Vol. 96, No. 6, 01.12.2017, p. 1041-1046.

Research output: Contribution to journal › Article › peer-review

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T1 - Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans

AU - Lee, Ji Young

AU - Moon, Sanghoon

AU - Kim, Yun Kyoung

AU - Lee, Sang Hak

AU - Lee, Bok Soo

AU - Park, Min Young

AU - Park, Jeong Euy

AU - Jang, Yangsoo

AU - Han, Bok Ghee

N1 - Funding Information: We thank all participants and investigators of the Korea Genome Epidemiology Study (KoGES). This work was supported by grants from the Korea Centers for Disease Control and Prevention (4845-301), an intramural grant from the Korea National Institute of Health (2012-N73003-00). Publisher Copyright: © 2017, Indian Academy of Sciences.

PY - 2017/12/1

Y1 - 2017/12/1

N2 - Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability in MI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of these genes with MI risk, and these associations have to be confirmed in other ethnic populations.

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Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans

Abstract

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