Abstract
Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability in MI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of these genes with MI risk, and these associations have to be confirmed in other ethnic populations.
| Original language | English |
|---|---|
| Pages (from-to) | 1041-1046 |
| Number of pages | 6 |
| Journal | Journal of Genetics |
| Volume | 96 |
| Issue number | 6 |
| DOIs | |
| Publication status | Published - 2017 Dec 1 |
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All Science Journal Classification (ASJC) codes
- Genetics
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Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans. / Lee, Ji Young; Moon, Sanghoon; Kim, Yun Kyoung; Lee, Sang Hak; Lee, Bok Soo; Park, Min Young; Park, Jeong Euy; Jang, Yangsoo; Han, Bok Ghee.
In: Journal of Genetics, Vol. 96, No. 6, 01.12.2017, p. 1041-1046.Research output: Contribution to journal › Article
TY - JOUR
T1 - Genome-based exome sequencing analysis identifies GYG1, DIS3L and DDRGK1 are associated with myocardial infarction in Koreans
AU - Lee, Ji Young
AU - Moon, Sanghoon
AU - Kim, Yun Kyoung
AU - Lee, Sang Hak
AU - Lee, Bok Soo
AU - Park, Min Young
AU - Park, Jeong Euy
AU - Jang, Yangsoo
AU - Han, Bok Ghee
PY - 2017/12/1
Y1 - 2017/12/1
N2 - Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability in MI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of these genes with MI risk, and these associations have to be confirmed in other ethnic populations.
AB - Myocardial infarction (MI) is a complex disease caused by combination of genetic and environmental factors. Although genome-wide association studies (GWAS) identified more than 46 risk loci which are associated with coronary artery disease and MI, most of the genetic variability in MI still remains undefined. Here, we screened the susceptibility loci for MI using exome sequencing and validated candidate variants in replication sets. We identified that three genes (GYG1, DIS3L and DDRGK1) were associated with MI at the discovery and replication stages. Further research will be required to determine the functional association of these genes with MI risk, and these associations have to be confirmed in other ethnic populations.
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U2 - 10.1007/s12041-017-0854-z
DO - 10.1007/s12041-017-0854-z
M3 - Article
C2 - 29321365
AN - SCOPUS:85035135184
VL - 96
SP - 1041
EP - 1046
JO - Journal of Genetics
JF - Journal of Genetics
SN - 0022-1333
IS - 6
ER -