Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent

Haeyoung Jeong, Joung Han Yim, Choonghwan Lee, Sang Haeng Choi, Yon Kyoung Park, Sung Ho Yoon, Cheol Goo Hur, Ho Young Kang, Dockyu Kim, Hyun Hee Lee, Kyun Hyang Park, Seung Hwan Park, Hong Seog Park, Hong Kum Lee, Tae Kwang Oh, Jihyun F. Kim

Research output: Contribution to journalArticle

117 Citations (Scopus)

Abstract

Harmful algal blooms, caused by rapid growth and accumulation of certain microalgae in the ocean, pose considerable impacts on marine environments, aquatic industries and even public health. Here, we present the 7.2-megabase genome of the marine bacterium Hahella chejuensis including genes responsible for the biosynthesis of a pigment which has the lytic activity against a red-tide dinoflagellate. H.chejuensis is the first sequenced species in the ceanospiralles clade, and sequence analysis revealed its distant relationship to the Pseudomonas group. The genome was well equipped with genes for basic metabolic capabilities and contained a large number of genes involved in regulation or transport as well as with characteristics as a marine heterotroph. Sequence analysis also revealed a multitude of genes of functional equivalence or of possible foreign origin. Functions encoded in the genomic islands include biosynthesis of exopolysacchrides, toxins, polyketides or non-ribosomal peptides, iron utilization, motility, type III protein secretion and pigmentation. Molecular structure of the algicidal pigment, which was determined through LC-ESI-MS/MS and NMR analyses, indicated that it is prodigiosin. In conclusion, our work provides new insights into mitigating algal blooms in addition to genetic make-up, physiology, biotic interactions and biological roles in the community of a marine bacterium.

Original languageEnglish
Pages (from-to)7066-7073
Number of pages8
JournalNucleic acids research
Volume33
Issue number22
DOIs
Publication statusPublished - 2005 Dec 1

Fingerprint

Harmful Algal Bloom
Genes
Sequence Analysis
Prodigiosin
Molecular Motor Proteins
Genome
Eutrophication
Bacteria
Microalgae
Polyketides
Genomic Islands
Dinoflagellida
Military Personnel
Pigmentation
Pseudomonas
Molecular Structure
Oceans and Seas
Industry
Iron
Public Health

All Science Journal Classification (ASJC) codes

  • Genetics

Cite this

Jeong, Haeyoung ; Yim, Joung Han ; Lee, Choonghwan ; Choi, Sang Haeng ; Park, Yon Kyoung ; Yoon, Sung Ho ; Hur, Cheol Goo ; Kang, Ho Young ; Kim, Dockyu ; Lee, Hyun Hee ; Park, Kyun Hyang ; Park, Seung Hwan ; Park, Hong Seog ; Lee, Hong Kum ; Oh, Tae Kwang ; Kim, Jihyun F. / Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent. In: Nucleic acids research. 2005 ; Vol. 33, No. 22. pp. 7066-7073.
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Jeong, H, Yim, JH, Lee, C, Choi, SH, Park, YK, Yoon, SH, Hur, CG, Kang, HY, Kim, D, Lee, HH, Park, KH, Park, SH, Park, HS, Lee, HK, Oh, TK & Kim, JF 2005, 'Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent', Nucleic acids research, vol. 33, no. 22, pp. 7066-7073. https://doi.org/10.1093/nar/gki1016

Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent. / Jeong, Haeyoung; Yim, Joung Han; Lee, Choonghwan; Choi, Sang Haeng; Park, Yon Kyoung; Yoon, Sung Ho; Hur, Cheol Goo; Kang, Ho Young; Kim, Dockyu; Lee, Hyun Hee; Park, Kyun Hyang; Park, Seung Hwan; Park, Hong Seog; Lee, Hong Kum; Oh, Tae Kwang; Kim, Jihyun F.

In: Nucleic acids research, Vol. 33, No. 22, 01.12.2005, p. 7066-7073.

Research output: Contribution to journalArticle

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T1 - Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent

AU - Jeong, Haeyoung

AU - Yim, Joung Han

AU - Lee, Choonghwan

AU - Choi, Sang Haeng

AU - Park, Yon Kyoung

AU - Yoon, Sung Ho

AU - Hur, Cheol Goo

AU - Kang, Ho Young

AU - Kim, Dockyu

AU - Lee, Hyun Hee

AU - Park, Kyun Hyang

AU - Park, Seung Hwan

AU - Park, Hong Seog

AU - Lee, Hong Kum

AU - Oh, Tae Kwang

AU - Kim, Jihyun F.

PY - 2005/12/1

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N2 - Harmful algal blooms, caused by rapid growth and accumulation of certain microalgae in the ocean, pose considerable impacts on marine environments, aquatic industries and even public health. Here, we present the 7.2-megabase genome of the marine bacterium Hahella chejuensis including genes responsible for the biosynthesis of a pigment which has the lytic activity against a red-tide dinoflagellate. H.chejuensis is the first sequenced species in the ceanospiralles clade, and sequence analysis revealed its distant relationship to the Pseudomonas group. The genome was well equipped with genes for basic metabolic capabilities and contained a large number of genes involved in regulation or transport as well as with characteristics as a marine heterotroph. Sequence analysis also revealed a multitude of genes of functional equivalence or of possible foreign origin. Functions encoded in the genomic islands include biosynthesis of exopolysacchrides, toxins, polyketides or non-ribosomal peptides, iron utilization, motility, type III protein secretion and pigmentation. Molecular structure of the algicidal pigment, which was determined through LC-ESI-MS/MS and NMR analyses, indicated that it is prodigiosin. In conclusion, our work provides new insights into mitigating algal blooms in addition to genetic make-up, physiology, biotic interactions and biological roles in the community of a marine bacterium.

AB - Harmful algal blooms, caused by rapid growth and accumulation of certain microalgae in the ocean, pose considerable impacts on marine environments, aquatic industries and even public health. Here, we present the 7.2-megabase genome of the marine bacterium Hahella chejuensis including genes responsible for the biosynthesis of a pigment which has the lytic activity against a red-tide dinoflagellate. H.chejuensis is the first sequenced species in the ceanospiralles clade, and sequence analysis revealed its distant relationship to the Pseudomonas group. The genome was well equipped with genes for basic metabolic capabilities and contained a large number of genes involved in regulation or transport as well as with characteristics as a marine heterotroph. Sequence analysis also revealed a multitude of genes of functional equivalence or of possible foreign origin. Functions encoded in the genomic islands include biosynthesis of exopolysacchrides, toxins, polyketides or non-ribosomal peptides, iron utilization, motility, type III protein secretion and pigmentation. Molecular structure of the algicidal pigment, which was determined through LC-ESI-MS/MS and NMR analyses, indicated that it is prodigiosin. In conclusion, our work provides new insights into mitigating algal blooms in addition to genetic make-up, physiology, biotic interactions and biological roles in the community of a marine bacterium.

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