Genomic blueprint of Hahella chejuensis, a marine microbe producing an algicidal agent

Haeyoung Jeong, Joung Han Yim, Choonghwan Lee, Sang Haeng Choi, Yon Kyoung Park, Sung Ho Yoon, Cheol Goo Hur, Ho Young Kang, Dockyu Kim, Hyun Hee Lee, Kyun Hyang Park, Seung Hwan Park, Hong Seog Park, Hong Kum Lee, Tae Kwang Oh, Jihyun F. Kim

Research output: Contribution to journalArticlepeer-review

122 Citations (Scopus)

Abstract

Harmful algal blooms, caused by rapid growth and accumulation of certain microalgae in the ocean, pose considerable impacts on marine environments, aquatic industries and even public health. Here, we present the 7.2-megabase genome of the marine bacterium Hahella chejuensis including genes responsible for the biosynthesis of a pigment which has the lytic activity against a red-tide dinoflagellate. H.chejuensis is the first sequenced species in the ceanospiralles clade, and sequence analysis revealed its distant relationship to the Pseudomonas group. The genome was well equipped with genes for basic metabolic capabilities and contained a large number of genes involved in regulation or transport as well as with characteristics as a marine heterotroph. Sequence analysis also revealed a multitude of genes of functional equivalence or of possible foreign origin. Functions encoded in the genomic islands include biosynthesis of exopolysacchrides, toxins, polyketides or non-ribosomal peptides, iron utilization, motility, type III protein secretion and pigmentation. Molecular structure of the algicidal pigment, which was determined through LC-ESI-MS/MS and NMR analyses, indicated that it is prodigiosin. In conclusion, our work provides new insights into mitigating algal blooms in addition to genetic make-up, physiology, biotic interactions and biological roles in the community of a marine bacterium.

Original languageEnglish
Pages (from-to)7066-7073
Number of pages8
JournalNucleic acids research
Volume33
Issue number22
DOIs
Publication statusPublished - 2005

Bibliographical note

Funding Information:
We thank John F. Heidelberg and Choong-Min Ryu for helpful suggestions on the manuscript, Jung-Hoon Yoon for comments on prokaryotic physiology, Jongsik Chun for providing information prior to publication, and Eun Kyoung Jeon, Jeong Im Lee, Mi Ok Yeon, Soohyun Yi and other GEM members as well as the KRIBB sequencing team for technical assistance. This work was funded by the 21C Frontier Microbial Genomics and Applications Center Program (to J.F.K. and C.L.) and by the National Research Laboratory Program (to H.K.L.) of the Ministry of Science and Technology, Korea. Funding to pay the Open Access publication charges for this article was provided by the 21C Frontier Microbial Genomics and Applications Center Program.

All Science Journal Classification (ASJC) codes

  • Genetics

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