Genomic organization and sequence of D12S53E (Pmel 17), the human homologue of the mouse silver (si) locus

Tu Bailin, Seung Taek Lee, Richard A. Spritz

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

We have determined the DNA sequence and genomic organization of D12S53E (Pmel 17), the human homologue of the mouse silver (si) locus. D12S53E encodes a melanosomal matrix protein whose expression is closely correlated with cellular melanin content and which is a frequent melanoma tumor antigen recognized by cytotoxic T lymphocytes. D12S53E is a likely candidate gene for some cases of human oculocutaneous albinism not associated with known albinism loci.

Original languageEnglish
Pages (from-to)24-27
Number of pages4
JournalJournal of Investigative Dermatology
Volume106
Issue number1
DOIs
Publication statusPublished - 1996

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Dermatology
  • Cell Biology

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