Genotypic shift of the hepatitis A virus and its clinical impact on acute hepatitis A in Korea

A nationwide multicenter study

Ji Hoon Kim, Jong Eun Yeon, Soonkoo Baik, Young Seok Kim, Hong Soo Kim, Sang Hoon Park, Myung Seok Lee, Joo Hyun Sohn, Jin Woo Lee, Sung Kyu Choi, So Young Kwon, Jong Young Choi, Ju Hyun Kim, Soon Young Kang, Hyonggin An, Yeon Seok Seo, Hyung Joon Yim, Jin Won Song, Soon Ho Um, Kwan Soo Byun

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Background: The genotypic shift of hepatitis A virus (HAV) and its correlation with clinical course has not been evaluated in acute hepatitis A (AHA). Methods: From June 2007 to May 2009, we prospectively enrolled 546 AHA patients. We performed a nested reverse transcriptase polymerase chain reaction (RT-PCR) using the serum samples in addition to phylogenetic analysis, then we compared patient clinical features. Results: Among 351 successfully genotyped patients, we found genotype IIIA in 178 patients (51%) and IA in 173 patients (49%). The sequences of genotype IA are identical to previously reported Korean genotype IA, and the new IIIA genotype is closely related to NOR24/Norway. We retrospectively analyzed 41 AHA samples collected from 2000 to 2006 and found that all of them were genotype IA. Patients with genotype IIIA showed significantly higher levels of aspartate aminotransferase, higher levels of alanine aminotransferase, and lower platelet counts than patients with genotype IA when comparing baseline laboratory data or peak/lowest laboratory data during the disease course. However, there were no differences in duration of hospital stay, incidence of cholestatic hepatitis, acute kidney injury, and acute liver failure, or mortality between them. Conclusions: A genotypic shift of the HAV was identified in Korean AHA subjects, and genotype IIIA HAV has become endemic. Although there were significant differences in the biochemical responses of AHA between genotype IA and genotype IIIA patients, we did not detect any differences in clinical outcomes such as complications or mortality.

Original languageEnglish
Pages (from-to)811-818
Number of pages8
JournalScandinavian Journal of Infectious Diseases
Volume45
Issue number11
DOIs
Publication statusPublished - 2013 Nov 1

Fingerprint

Hepatitis A virus
Hepatitis A
Korea
Multicenter Studies
Genotype
Acute Liver Failure
Mortality
Norway
Aspartate Aminotransferases
Reverse Transcriptase Polymerase Chain Reaction
Alanine Transaminase
Platelet Count
Acute Kidney Injury
Hepatitis
Length of Stay

All Science Journal Classification (ASJC) codes

  • Immunology and Microbiology(all)
  • Microbiology (medical)
  • Infectious Diseases

Cite this

Kim, Ji Hoon ; Yeon, Jong Eun ; Baik, Soonkoo ; Kim, Young Seok ; Kim, Hong Soo ; Park, Sang Hoon ; Lee, Myung Seok ; Sohn, Joo Hyun ; Lee, Jin Woo ; Choi, Sung Kyu ; Kwon, So Young ; Choi, Jong Young ; Kim, Ju Hyun ; Kang, Soon Young ; An, Hyonggin ; Seo, Yeon Seok ; Yim, Hyung Joon ; Song, Jin Won ; Um, Soon Ho ; Byun, Kwan Soo. / Genotypic shift of the hepatitis A virus and its clinical impact on acute hepatitis A in Korea : A nationwide multicenter study. In: Scandinavian Journal of Infectious Diseases. 2013 ; Vol. 45, No. 11. pp. 811-818.
@article{35e1f0b46bb9403893dddd20cd87e7d9,
title = "Genotypic shift of the hepatitis A virus and its clinical impact on acute hepatitis A in Korea: A nationwide multicenter study",
abstract = "Background: The genotypic shift of hepatitis A virus (HAV) and its correlation with clinical course has not been evaluated in acute hepatitis A (AHA). Methods: From June 2007 to May 2009, we prospectively enrolled 546 AHA patients. We performed a nested reverse transcriptase polymerase chain reaction (RT-PCR) using the serum samples in addition to phylogenetic analysis, then we compared patient clinical features. Results: Among 351 successfully genotyped patients, we found genotype IIIA in 178 patients (51{\%}) and IA in 173 patients (49{\%}). The sequences of genotype IA are identical to previously reported Korean genotype IA, and the new IIIA genotype is closely related to NOR24/Norway. We retrospectively analyzed 41 AHA samples collected from 2000 to 2006 and found that all of them were genotype IA. Patients with genotype IIIA showed significantly higher levels of aspartate aminotransferase, higher levels of alanine aminotransferase, and lower platelet counts than patients with genotype IA when comparing baseline laboratory data or peak/lowest laboratory data during the disease course. However, there were no differences in duration of hospital stay, incidence of cholestatic hepatitis, acute kidney injury, and acute liver failure, or mortality between them. Conclusions: A genotypic shift of the HAV was identified in Korean AHA subjects, and genotype IIIA HAV has become endemic. Although there were significant differences in the biochemical responses of AHA between genotype IA and genotype IIIA patients, we did not detect any differences in clinical outcomes such as complications or mortality.",
author = "Kim, {Ji Hoon} and Yeon, {Jong Eun} and Soonkoo Baik and Kim, {Young Seok} and Kim, {Hong Soo} and Park, {Sang Hoon} and Lee, {Myung Seok} and Sohn, {Joo Hyun} and Lee, {Jin Woo} and Choi, {Sung Kyu} and Kwon, {So Young} and Choi, {Jong Young} and Kim, {Ju Hyun} and Kang, {Soon Young} and Hyonggin An and Seo, {Yeon Seok} and Yim, {Hyung Joon} and Song, {Jin Won} and Um, {Soon Ho} and Byun, {Kwan Soo}",
year = "2013",
month = "11",
day = "1",
doi = "10.3109/00365548.2013.805425",
language = "English",
volume = "45",
pages = "811--818",
journal = "Infectious Diseases",
issn = "2374-4235",
publisher = "Taylor and Francis Ltd.",
number = "11",

}

Kim, JH, Yeon, JE, Baik, S, Kim, YS, Kim, HS, Park, SH, Lee, MS, Sohn, JH, Lee, JW, Choi, SK, Kwon, SY, Choi, JY, Kim, JH, Kang, SY, An, H, Seo, YS, Yim, HJ, Song, JW, Um, SH & Byun, KS 2013, 'Genotypic shift of the hepatitis A virus and its clinical impact on acute hepatitis A in Korea: A nationwide multicenter study', Scandinavian Journal of Infectious Diseases, vol. 45, no. 11, pp. 811-818. https://doi.org/10.3109/00365548.2013.805425

Genotypic shift of the hepatitis A virus and its clinical impact on acute hepatitis A in Korea : A nationwide multicenter study. / Kim, Ji Hoon; Yeon, Jong Eun; Baik, Soonkoo; Kim, Young Seok; Kim, Hong Soo; Park, Sang Hoon; Lee, Myung Seok; Sohn, Joo Hyun; Lee, Jin Woo; Choi, Sung Kyu; Kwon, So Young; Choi, Jong Young; Kim, Ju Hyun; Kang, Soon Young; An, Hyonggin; Seo, Yeon Seok; Yim, Hyung Joon; Song, Jin Won; Um, Soon Ho; Byun, Kwan Soo.

In: Scandinavian Journal of Infectious Diseases, Vol. 45, No. 11, 01.11.2013, p. 811-818.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Genotypic shift of the hepatitis A virus and its clinical impact on acute hepatitis A in Korea

T2 - A nationwide multicenter study

AU - Kim, Ji Hoon

AU - Yeon, Jong Eun

AU - Baik, Soonkoo

AU - Kim, Young Seok

AU - Kim, Hong Soo

AU - Park, Sang Hoon

AU - Lee, Myung Seok

AU - Sohn, Joo Hyun

AU - Lee, Jin Woo

AU - Choi, Sung Kyu

AU - Kwon, So Young

AU - Choi, Jong Young

AU - Kim, Ju Hyun

AU - Kang, Soon Young

AU - An, Hyonggin

AU - Seo, Yeon Seok

AU - Yim, Hyung Joon

AU - Song, Jin Won

AU - Um, Soon Ho

AU - Byun, Kwan Soo

PY - 2013/11/1

Y1 - 2013/11/1

N2 - Background: The genotypic shift of hepatitis A virus (HAV) and its correlation with clinical course has not been evaluated in acute hepatitis A (AHA). Methods: From June 2007 to May 2009, we prospectively enrolled 546 AHA patients. We performed a nested reverse transcriptase polymerase chain reaction (RT-PCR) using the serum samples in addition to phylogenetic analysis, then we compared patient clinical features. Results: Among 351 successfully genotyped patients, we found genotype IIIA in 178 patients (51%) and IA in 173 patients (49%). The sequences of genotype IA are identical to previously reported Korean genotype IA, and the new IIIA genotype is closely related to NOR24/Norway. We retrospectively analyzed 41 AHA samples collected from 2000 to 2006 and found that all of them were genotype IA. Patients with genotype IIIA showed significantly higher levels of aspartate aminotransferase, higher levels of alanine aminotransferase, and lower platelet counts than patients with genotype IA when comparing baseline laboratory data or peak/lowest laboratory data during the disease course. However, there were no differences in duration of hospital stay, incidence of cholestatic hepatitis, acute kidney injury, and acute liver failure, or mortality between them. Conclusions: A genotypic shift of the HAV was identified in Korean AHA subjects, and genotype IIIA HAV has become endemic. Although there were significant differences in the biochemical responses of AHA between genotype IA and genotype IIIA patients, we did not detect any differences in clinical outcomes such as complications or mortality.

AB - Background: The genotypic shift of hepatitis A virus (HAV) and its correlation with clinical course has not been evaluated in acute hepatitis A (AHA). Methods: From June 2007 to May 2009, we prospectively enrolled 546 AHA patients. We performed a nested reverse transcriptase polymerase chain reaction (RT-PCR) using the serum samples in addition to phylogenetic analysis, then we compared patient clinical features. Results: Among 351 successfully genotyped patients, we found genotype IIIA in 178 patients (51%) and IA in 173 patients (49%). The sequences of genotype IA are identical to previously reported Korean genotype IA, and the new IIIA genotype is closely related to NOR24/Norway. We retrospectively analyzed 41 AHA samples collected from 2000 to 2006 and found that all of them were genotype IA. Patients with genotype IIIA showed significantly higher levels of aspartate aminotransferase, higher levels of alanine aminotransferase, and lower platelet counts than patients with genotype IA when comparing baseline laboratory data or peak/lowest laboratory data during the disease course. However, there were no differences in duration of hospital stay, incidence of cholestatic hepatitis, acute kidney injury, and acute liver failure, or mortality between them. Conclusions: A genotypic shift of the HAV was identified in Korean AHA subjects, and genotype IIIA HAV has become endemic. Although there were significant differences in the biochemical responses of AHA between genotype IA and genotype IIIA patients, we did not detect any differences in clinical outcomes such as complications or mortality.

UR - http://www.scopus.com/inward/record.url?scp=84885900777&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84885900777&partnerID=8YFLogxK

U2 - 10.3109/00365548.2013.805425

DO - 10.3109/00365548.2013.805425

M3 - Article

VL - 45

SP - 811

EP - 818

JO - Infectious Diseases

JF - Infectious Diseases

SN - 2374-4235

IS - 11

ER -