Gentamicin-intercalated smectite as a new therapeutic option for Helicobacter pylori eradication

Su Jin Jeong, Jie Hyun Kim, Da Hyun Jung, Kyoung Hwa Lee, Soon Young Park, Yungoo Song, Il Mo Kang, Young Goo Song

Research output: Contribution to journalArticlepeer-review

7 Citations (Scopus)


Objectives: Novel antibacterial strategies against Helicobacter pylori are needed because H. pylori strains are acquiring resistance to antibiotics. We evaluated the efficacy of gentamicin-intercalated smectite hybrid (S-GEN)-based treatment regimens in amurine model of H. pylori infection. Methods: Two groups of 10 rats were administered either smectite or S-GEN to measure coverage of the gastric mucosa. To evaluate anti-H. pylori efficacy, mice were divided into eight groups of 10 mice each given different treatments, and H. pylori eradication was assessed by a Campylobacter-like organism(CLO) test and H. pylori PCR of the gastric mucosa, and H. pylori antigen and H. pylori PCR analysis of mouse faeces. The levels of proinflammatory cytokines were examined. Results: S-GEN was retained in the gastric mucosal layer with a > 60% distribution ratio for up to 1 h, and the S-GEN-based triple regimen decreased bacterial burden in vivo compared with that of untreated mice or mice treated with other regimens. The cure rates in the CLO test and H. pylori PCR from gastric mucosa were 70%, 60%, 80%, 50%, 60% and 60% in Groups III-VIII, respectively. Those for H. pylori PCR in the faeces of mice were 90% and 100% in Group III with standard therapy and Group V with triple therapy including S-GEN, respectively. S-GEN triple therapy also reduced the levels of proinflammatory cytokines. Conclusions: These results suggest that S-GEN is a promising and effective therapeutic agent for the treatment of H. pylori infection.

Original languageEnglish
Pages (from-to)1324-1329
Number of pages6
JournalJournal of Antimicrobial Chemotherapy
Issue number5
Publication statusPublished - 2018 May 1

Bibliographical note

Funding Information:
This work was supported by the Basic Research Project (Study No. 16-3220) of the Korea Institute of Geoscience and Mineral Resources funded by the Ministry of Science, Information and Communication Technology and Future Planning of Korea.

Publisher Copyright:
© The Author(s) 2018. Published by Oxford University Press on behalf of the British Society for Antimicrobial Chemotherapy. All rights reserved.

All Science Journal Classification (ASJC) codes

  • Pharmacology
  • Microbiology (medical)
  • Infectious Diseases
  • Pharmacology (medical)


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